ENSMUSG00000046634


Mus musculus

Features
Gene ID: ENSMUSG00000046634
  
Biological name :Pkd1l1
  
Synonyms : Pkd1l1 / polycystin 1 like 1, transient receptor potential channel interacting
  
Possible biological names infered from orthology : Q8TDX9
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: A1
Gene start: 8826708
Gene end: 8973266
  
Corresponding Affymetrix probe sets: 10384266 (MoGene1.0st)   1443072_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000120803
Ensembl peptide - ENSMUSP00000136518
NCBI entrez gene - 171395     See in Manteia.
MGI - MGI:2156538
RefSeq - XM_017314870
swissprot - A0A0A0MQP1
swissprot - A0A0A0MQK4
Ensembl - ENSMUSG00000046634
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PKD1L1ENSG00000158683Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pkd1 / O08852 / Polycystin-1 / P98161* / polycystin 1, transient receptor potential channel interacting*ENSMUSG0000003285516
Pkd1l2ENSMUSG0000003441615
Pkdrej / polycystin family receptor for egg jelly / Q9NTG1*ENSMUSG0000005249613
Pkd1l3 / Q2EG98 / Polycystic kidney disease protein 1-like 3 / Q7Z443* / polycystin 1 like 3, transient receptor potential channel interacting*ENSMUSG0000004882712
Pkd2 / O35245 / Polycystin-2 / Q13563* / polycystin 2, transient receptor potential cation channel*ENSMUSG000000344625
Pkd2l2 / Q9JLG4 / Polycystic kidney disease 2-like 2 protein / Q9NZM6* / polycystin 2 like 2, transient receptor potential cation channel*ENSMUSG000000145034
A2A259 / Pkd2l1 / Polycystic kidney disease 2-like 1 protein / Q9P0L9* / polycystin 2 like 1, transient receptor potential cation channel*ENSMUSG000000375784


Protein motifs (from Interpro)
Interpro ID Name
 IPR000601  PKD domain
 IPR001024  PLAT/LH2 domain
 IPR002859  PKD/REJ-like domain
 IPR013122  Polycystin cation channel, PKD1/PKD2
 IPR013783  Immunoglobulin-like fold
 IPR014010  REJ domain
 IPR022409  PKD/Chitinase domain
 IPR035986  PKD domain superfamily
 IPR036392  PLAT/LH2 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034704 calcium channel complex IEA
 cellular_componentGO:0097730 non-motile cilium IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005515 protein binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000531 right pulmonary isomerism "bilaterally symmetric right lung pattern (or altered asymmetric patterning of the lung)" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator, J:58530]
Show

Allelic Composition: Fzd4tm1Nat/Fzd4tm2.1Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0000644 dextrocardia "cardiac apex pointing to the right as opposed to the normal levocardia" [ava:Anna V. Anagnostopoulos, Mouse Genome Informatics Curator]
Show

Allelic Composition: Fzd4tm1Nat/Fzd4tm2.1Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001706 abnormal left-right axis patterning "anomaly in the formation or development of the body or a specific organ of the body in relation to the left and right sides of the body or organ" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fzd4tm1Nat/Fzd4tm2.1Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001730 embryonic growth arrest "the cessation of development beyond a particular stage" [J:17509]
Show

Allelic Composition: Fzd4tm1Nat/Fzd4tm2.1Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0001785 edema "an accumulation of an excessive amount of watery fluid in cells or intercellular tissues" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:54065]
Show

Allelic Composition: Fzd4tm1Nat/Fzd4tm2.1Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fzd4tm1Nat/Fzd4tm2.1Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0002766 situs inversus "lateral transposition of the viscera of the thorax and abdomen, sometimes incomplete" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Fmr1tm1Cgr/Fmr1tm1Cgr
Genetic Background: B6.129P2-Fmr1tm1Cgr

 MP:0003984 embryonic growth retardation "slow or limited development before birth" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Fzd4tm1Nat/Fzd4tm2.1Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004190 abnormal direction of embryo turning "axial rotation of the embryo in a direction other than the normal anticlockwise direction when viewed towards the caudal pole during the late primitive streak/early somite stage (Mus E8.5-E9.5); clockwise rotation is frequently associated with heart and visceral defects" [ISBN:0-12-402035-6 "Kaufman, MH The Atlas of Mouse Development"]
Show

Allelic Composition: Fzd4tm1Nat/Fzd4tm2.1Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0010808 right-sided stomach "stomach is present on the right side of the body instead of the left" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Fzd4tm1Nat/Fzd4tm2.1Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011086 partial postnatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms anytime between the neonatal period and weaning age (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Fmr1tm1Cgr/Fmr1tm1Cgr
Genetic Background: B6.129P2-Fmr1tm1Cgr

 MP:0011099 complete lethality throughout fetal growth and development "death of all organisms of a given genotype in a population between the completion of organogenesis and birth (Mus: E14 to approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Fzd4tm1Nat/Fzd4tm2.1Nat,Gt(ROSA)26Sortm1(cre/ERT)Nat/Gt(ROSA)26Sor+
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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