ENSMUSG00000037578


Mus musculus

Features
Gene ID: ENSMUSG00000037578
  
Biological name :Pkd2l1
  
Synonyms : A2A259 / Pkd2l1 / Polycystic kidney disease 2-like 1 protein
  
Possible biological names infered from orthology : polycystin 2 like 1, transient receptor potential cation channel / Q9P0L9
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 44147637
Gene end: 44192442
  
Corresponding Affymetrix probe sets: 10467962 (MoGene1.0st)   1457105_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000045675
NCBI entrez gene - 329064     See in Manteia.
MGI - MGI:1352448
RefSeq - XM_017318225
RefSeq - NM_181422
RefSeq - XM_017318223
RefSeq - XM_017318224
RefSeq - XM_006527143
RefSeq - XM_011247267
RefSeq - XM_017318220
RefSeq - XM_017318221
RefSeq - XM_017318222
RefSeq Peptide - NP_852087
swissprot - A2A259
Ensembl - ENSMUSG00000037578
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pkd2l1ENSDARG00000022503Danio rerio
 PKD2L1ENSGALG00000005766Gallus gallus
 PKD2L1ENSG00000107593Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pkd2 / O35245 / Polycystin-2 / Q13563* / polycystin 2, transient receptor potential cation channel*ENSMUSG0000003446250
Pkd2l2 / Q9JLG4 / Polycystic kidney disease 2-like 2 protein / Q9NZM6* / polycystin 2 like 2, transient receptor potential cation channel*ENSMUSG0000001450337
Pkd1l2ENSMUSG0000003441622
Pkd1l3 / Q2EG98 / Polycystic kidney disease protein 1-like 3 / Q7Z443* / polycystin 1 like 3, transient receptor potential channel interacting*ENSMUSG0000004882718
Pkdrej / polycystin family receptor for egg jelly / Q9NTG1*ENSMUSG0000005249617
Pkd1 / O08852 / Polycystin-1 / P98161* / polycystin 1, transient receptor potential channel interacting*ENSMUSG0000003285516
Pkd1l1 / polycystin 1 like 1, transient receptor potential channel interacting / Q8TDX9*ENSMUSG0000004663414


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR003915  Polycystic kidney disease type 2 protein
 IPR011992  EF-hand domain pair
 IPR013122  Polycystin cation channel, PKD1/PKD2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001581 detection of chemical stimulus involved in sensory perception of sour taste IDA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IDA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0050915 sensory perception of sour taste IEA
 biological_processGO:0050982 detection of mechanical stimulus IBA
 biological_processGO:0070207 protein homotrimerization IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071468 cellular response to acidic pH IDA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005783 endoplasmic reticulum IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane ISO
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0034703 cation channel complex IDA
 cellular_componentGO:0034704 calcium channel complex IMP
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IEA
 cellular_componentGO:0043235 receptor complex IDA
 cellular_componentGO:0060170 ciliary membrane IEA
 cellular_componentGO:0097730 non-motile cilium IEA
 molecular_functionGO:0005227 calcium activated cation channel activity IEA
 molecular_functionGO:0005261 cation channel activity IEA
 molecular_functionGO:0005262 calcium channel activity ISO
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0008324 cation transmembrane transporter activity IDA
 molecular_functionGO:0015269 calcium-activated potassium channel activity IEA
 molecular_functionGO:0033040 sour taste receptor activity IDA
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0051371 muscle alpha-actinin binding IEA
 molecular_functionGO:0051393 alpha-actinin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001985 abnormal gustatory system physiology "anomalous perception of taste" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Aspatm1a(EUCOMM)Wtsi/Aspatm1a(EUCOMM)Wtsi
Genetic Background: involves: C57BL/6J * C57BL/6N

Allelic Composition: Pkd2l1tm1.1Yuni/Pkd2l1tm1.1Yuni
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Pkd1l3tm1.1Abek/Pkd1l3tm1.1Abek,Pkd2l1tm1.1Yuni/Pkd2l1tm1.1Yuni
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

 MP:0003477 abnormal nerve fiber response "anomaly in the electrophysiological recordings from a single or several nerve fiber(s)" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Gad1tm1.1Tama/Gad1+,Pkd2l1tm1.1Yuni/Pkd2l1tm1.1Yuni
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Allelic Composition: Pkd2l1tm1.1Yuni/Pkd2l1tm1.1Yuni
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Pkd1l3tm1.1Abek/Pkd1l3tm1.1Abek,Pkd2l1tm1.1Yuni/Pkd2l1tm1.1Yuni
Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr