ENSG00000107593


Homo sapiens

Features
Gene ID: ENSG00000107593
  
Biological name :PKD2L1
  
Synonyms : PKD2L1 / polycystin 2 like 1, transient receptor potential cation channel / Q9P0L9
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: -1
Band: q24.31
Gene start: 100288154
Gene end: 100330486
  
Corresponding Affymetrix probe sets: 221061_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000436514
Ensembl peptide - ENSP00000325296
Ensembl peptide - ENSP00000434019
Ensembl peptide - ENSP00000434224
NCBI entrez gene - 9033     See in Manteia.
OMIM - 604532
RefSeq - XM_017016876
RefSeq - NM_001253837
RefSeq - NM_016112
RefSeq - XM_011540323
RefSeq - XM_011540325
RefSeq - XM_017016875
RefSeq Peptide - NP_057196
RefSeq Peptide - NP_001240766
swissprot - H0YDN7
swissprot - H0YET4
swissprot - Q9P0L9
swissprot - E9PRD1
Ensembl - ENSG00000107593
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pkd2l1ENSDARG00000022503Danio rerio
 PKD2L1ENSGALG00000005766Gallus gallus
 A2A259ENSMUSG00000037578Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PKD2 / Q13563 / polycystin 2, transient receptor potential cation channelENSG0000011876250
PKD2L2 / Q9NZM6 / polycystin 2 like 2, transient receptor potential cation channelENSG0000007879536
PKD1 / P98161 / polycystin 1, transient receptor potential channel interactingENSG0000000871018
PKDREJ / Q9NTG1 / polycystin family receptor for egg jellyENSG0000013094317
PKD1L1 / Q8TDX9 / polycystin 1 like 1, transient receptor potential channel interactingENSG0000015868315
PKD1L3 / Q7Z443 / polycystin 1 like 3, transient receptor potential channel interactingENSG0000027748112
PKD1L2 / Q7Z442 / polycystin 1 like 2 (gene/pseudogene)ENSG000001664731


Protein motifs (from Interpro)
Interpro ID Name
 IPR003915  Polycystic kidney disease type 2 protein
 IPR013122  Polycystin cation channel, PKD1/PKD2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001581 detection of chemical stimulus involved in sensory perception of sour taste IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007224 smoothened signaling pathway IEA
 biological_processGO:0035725 sodium ion transmembrane transport IDA
 biological_processGO:0050915 sensory perception of sour taste IMP
 biological_processGO:0050982 detection of mechanical stimulus IBA
 biological_processGO:0070207 protein homotrimerization IDA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071468 cellular response to acidic pH IEA
 biological_processGO:0071805 potassium ion transmembrane transport IDA
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005886 plasma membrane IMP
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane NAS
 cellular_componentGO:0034703 cation channel complex IEA
 cellular_componentGO:0034704 calcium channel complex IEA
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:0043231 intracellular membrane-bounded organelle IDA
 cellular_componentGO:0043235 receptor complex IEA
 cellular_componentGO:0060170 ciliary membrane IEA
 cellular_componentGO:0097730 non-motile cilium IDA
 molecular_functionGO:0005227 calcium activated cation channel activity IDA
 molecular_functionGO:0005261 cation channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IDA
 molecular_functionGO:0005509 calcium ion binding ISS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008092 cytoskeletal protein binding IPI
 molecular_functionGO:0008324 cation transmembrane transporter activity IEA
 molecular_functionGO:0015269 calcium-activated potassium channel activity IDA
 molecular_functionGO:0033040 sour taste receptor activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0051371 muscle alpha-actinin binding IPI
 molecular_functionGO:0051393 alpha-actinin binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr