ENSGALG00000005714


Gallus gallus

Features
Gene ID: ENSGALG00000005714
  
Biological name :PKD1
  
Synonyms : PKD1 / polycystin 1, transient receptor potential channel interacting
  
Possible biological names infered from orthology : O08852 / P98161 / Polycystin-1
  
Species: Gallus gallus
  
Chr. number: 14
Strand: -1
Band:
Gene start: 6339857
Gene end: 6422473
  
Corresponding Affymetrix probe sets: Gga.19764.1.S1_s_at (Chicken Array)   GgaAffx.26572.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000049180
Ensembl peptide - ENSGALP00000009154
NCBI entrez gene - 416553     See in Manteia.
RefSeq - XM_414854
RefSeq - XM_015294444
RefSeq - XM_015294445
swissprot - F1N838
swissprot - A0A1D5P8Y1
Ensembl - ENSGALG00000005714
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pkd1aENSDARG00000030417Danio rerio
 PKD1ENSG00000008710Homo sapiens
 Pkd1ENSMUSG00000032855Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Pkd1l2*ENSGALG0000000543510
PKD2L1 / polycystin 2 like 1, transient receptor potential cation channel / A2A259* / Q9P0L9* / Polycystic kidney disease 2-like 1 protein *ENSGALG000000057663
PKD2 / polycystin-2 / O35245* / Q13563* / polycystin 2, transient receptor potential cation channel*ENSGALG000000109213
PKD2L2 / polycystin 2 like 2, transient receptor potential cation channel / Q9JLG4* / Q9NZM6* / Polycystic kidney disease 2-like 2 protein *ENSGALG000000061202
PKDREJ* / Q9NTG1* / polycystin family receptor for egg jelly*ENSGALG000000391331


Protein motifs (from Interpro)
Interpro ID Name
 IPR000203  GPS motif
 IPR000434  Polycystic kidney disease type 1 protein
 IPR000483  Cysteine-rich flanking region, C-terminal
 IPR000601  PKD domain
 IPR001024  PLAT/LH2 domain
 IPR001304  C-type lectin-like
 IPR001611  Leucine-rich repeat
 IPR002859  PKD/REJ-like domain
 IPR002889  Carbohydrate-binding WSC
 IPR003591  Leucine-rich repeat, typical subtype
 IPR006228  Polycystin cation channel
 IPR013122  Polycystin cation channel, PKD1/PKD2
 IPR014010  REJ domain
 IPR016186  C-type lectin-like/link domain superfamily
 IPR016187  C-type lectin fold
 IPR022409  PKD/Chitinase domain
 IPR032675  Leucine-rich repeat domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001502 cartilage condensation IEA
 biological_processGO:0001568 blood vessel development IEA
 biological_processGO:0001701 in utero embryonic development IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001892 embryonic placenta development IEA
 biological_processGO:0006611 protein export from nucleus IEA
 biological_processGO:0006807 nitrogen compound metabolic process IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007259 JAK-STAT cascade IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0018105 peptidyl-serine phosphorylation IEA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0030010 establishment of cell polarity IEA
 biological_processGO:0030155 regulation of cell adhesion IEA
 biological_processGO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle IEA
 biological_processGO:0032092 positive regulation of protein binding IEA
 biological_processGO:0034405 response to fluid shear stress IEA
 biological_processGO:0036303 lymph vessel morphogenesis IEA
 biological_processGO:0042994 cytoplasmic sequestering of transcription factor IEA
 biological_processGO:0043588 skin development IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0048565 digestive tract development IEA
 biological_processGO:0048754 branching morphogenesis of an epithelial tube IEA
 biological_processGO:0048806 genitalia development IEA
 biological_processGO:0050982 detection of mechanical stimulus IEA
 biological_processGO:0051216 cartilage development IEA
 biological_processGO:0060236 regulation of mitotic spindle organization IEA
 biological_processGO:0060428 lung epithelium development IEA
 biological_processGO:0060674 placenta blood vessel development IEA
 biological_processGO:0061136 regulation of proteasomal protein catabolic process IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0072001 renal system development IEA
 biological_processGO:0072164 mesonephric tubule development IEA
 biological_processGO:0072177 mesonephric duct development IEA
 biological_processGO:0072205 metanephric collecting duct development IEA
 biological_processGO:0072218 metanephric ascending thin limb development IEA
 biological_processGO:0072237 metanephric proximal tubule development IEA
 biological_processGO:0072287 metanephric distal tubule morphogenesis IEA
 biological_processGO:0098609 cell-cell adhesion IEA
 cellular_componentGO:0002133 polycystin complex IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0070062 extracellular exosome IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0019904 protein domain specific binding IEA
 molecular_functionGO:0044325 ion channel binding IEA


Pathways (from Reactome)
Pathway description
VxPx cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSGALG00000028851 RAB8A / Q5F470 / Ras-related protein Rab-8A / P61006* / P55258* / RAB8A, member RAS oncogene family*  / complex / reaction
 ENSGALG00000007615 Q5ZJN2 / RAB11A / Ras-related protein Rab-11A / P62491* / P62492* / RAB11A, member RAS oncogene family*  / complex
 ENSGALG00000005622 ARF4 / ADP ribosylation factor 4 / P18085* / P61750*  / complex / reaction
 ENSGALG00000009959 Q68EF0* / Q96QF0* / RAB3IP* / AC025263.2* / RAB3A interacting protein*  / complex / reaction
 ENSGALG00000037618 ASAP1 / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 / Q9QWY8* / Q9ULH1* / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 *  / complex






 

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