ENSGALG00000010921


Gallus gallus

Features
Gene ID: ENSGALG00000010921
  
Biological name :PKD2
  
Synonyms : PKD2 / polycystin-2
  
Possible biological names infered from orthology : O35245 / polycystin 2, transient receptor potential cation channel / Q13563
  
Species: Gallus gallus
  
Chr. number: 4
Strand: -1
Band:
Gene start: 45959958
Gene end: 45974346
  
Corresponding Affymetrix probe sets: Gga.6054.1.S1_at (Chicken Array)   Gga.6054.2.S1_s_at (Chicken Array)   
  
Cross references: Ensembl peptide - ENSGALP00000048540
Ensembl peptide - ENSGALP00000037340
NCBI entrez gene - 422585     See in Manteia.
RefSeq - NM_001031140
RefSeq Peptide - NP_001026311
swissprot - F1NDJ6
swissprot - A0A1D5P756
Ensembl - ENSGALG00000010921
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 pkd2ENSDARG00000014098Danio rerio
 PKD2ENSG00000118762Homo sapiens
 Pkd2ENSMUSG00000034462Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PKD2L1 / polycystin 2 like 1, transient receptor potential cation channel / A2A259* / Q9P0L9* / Polycystic kidney disease 2-like 1 protein *ENSGALG0000000576644
PKD2L2 / polycystin 2 like 2, transient receptor potential cation channel / Q9JLG4* / Q9NZM6* / Polycystic kidney disease 2-like 2 protein *ENSGALG0000000612023
Pkd1l2*ENSGALG0000000543519
PKD1 / polycystin 1, transient receptor potential channel interacting / O08852* / P98161* / Polycystin-1 *ENSGALG0000000571417
PKDREJ* / Q9NTG1* / polycystin family receptor for egg jelly*ENSGALG000000391331


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR003915  Polycystic kidney disease type 2 protein
 IPR011992  EF-hand domain pair
 IPR013122  Polycystin cation channel, PKD1/PKD2
 IPR027359  Voltage-dependent channel domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001658 branching involved in ureteric bud morphogenesis IEA
 biological_processGO:0001822 kidney development IEA
 biological_processGO:0001889 liver development IEA
 biological_processGO:0001892 embryonic placenta development IEA
 biological_processGO:0001947 heart looping IEA
 biological_processGO:0003127 detection of nodal flow IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0007050 cell cycle arrest IEA
 biological_processGO:0007259 JAK-STAT cascade IEA
 biological_processGO:0007368 determination of left/right symmetry IEA
 biological_processGO:0007507 heart development IEA
 biological_processGO:0010628 positive regulation of gene expression IEA
 biological_processGO:0021510 spinal cord development IEA
 biological_processGO:0021915 neural tube development IEA
 biological_processGO:0030814 obsolete regulation of cAMP metabolic process IEA
 biological_processGO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity IEA
 biological_processGO:0031659 positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle IEA
 biological_processGO:0035502 metanephric part of ureteric bud development IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0035904 aorta development IEA
 biological_processGO:0042127 regulation of cell proliferation IEA
 biological_processGO:0042994 cytoplasmic sequestering of transcription factor IEA
 biological_processGO:0045429 positive regulation of nitric oxide biosynthetic process IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0050982 detection of mechanical stimulus IEA
 biological_processGO:0051209 release of sequestered calcium ion into cytosol IEA
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0060315 negative regulation of ryanodine-sensitive calcium-release channel activity IEA
 biological_processGO:0060674 placenta blood vessel development IEA
 biological_processGO:0061333 renal tubule morphogenesis IEA
 biological_processGO:0061441 renal artery morphogenesis IEA
 biological_processGO:0070588 calcium ion transmembrane transport IEA
 biological_processGO:0071158 positive regulation of cell cycle arrest IEA
 biological_processGO:0071277 cellular response to calcium ion IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071464 cellular response to hydrostatic pressure IEA
 biological_processGO:0071470 cellular response to osmotic stress IEA
 biological_processGO:0071498 cellular response to fluid shear stress IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0071910 determination of liver left/right asymmetry IEA
 biological_processGO:0072001 renal system development IEA
 biological_processGO:0072075 metanephric mesenchyme development IEA
 biological_processGO:0072164 mesonephric tubule development IEA
 biological_processGO:0072177 mesonephric duct development IEA
 biological_processGO:0072208 metanephric smooth muscle tissue development IEA
 biological_processGO:0072214 metanephric cortex development IEA
 biological_processGO:0072218 metanephric ascending thin limb development IEA
 biological_processGO:0072219 metanephric cortical collecting duct development IEA
 biological_processGO:0072235 metanephric distal tubule development IEA
 biological_processGO:0072284 metanephric S-shaped body morphogenesis IEA
 biological_processGO:0090279 regulation of calcium ion import IEA
 biological_processGO:2000134 negative regulation of G1/S transition of mitotic cell cycle IEA
 cellular_componentGO:0002133 polycystin complex IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0005911 cell-cell junction IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0009925 basal plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030027 lamellipodium IEA
 cellular_componentGO:0031514 motile cilium IEA
 cellular_componentGO:0031941 filamentous actin IEA
 cellular_componentGO:0036064 ciliary basal body IEA
 cellular_componentGO:0045180 basal cortex IEA
 cellular_componentGO:0060170 ciliary membrane IEA
 cellular_componentGO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane IEA
 cellular_componentGO:0071556 integral component of lumenal side of endoplasmic reticulum membrane IEA
 cellular_componentGO:0072686 mitotic spindle IEA
 cellular_componentGO:0097730 non-motile cilium IEA
 molecular_functionGO:0005102 signaling receptor binding IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005245 voltage-gated calcium channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0008092 cytoskeletal protein binding IEA
 molecular_functionGO:0015267 channel activity IEA
 molecular_functionGO:0015271 outward rectifier potassium channel activity IEA
 molecular_functionGO:0022843 voltage-gated cation channel activity IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0042805 actinin binding IEA
 molecular_functionGO:0043398 HLH domain binding IEA
 molecular_functionGO:0044325 ion channel binding IEA
 molecular_functionGO:0048763 calcium-induced calcium release activity IEA
 molecular_functionGO:0051117 ATPase binding IEA
 molecular_functionGO:0051219 phosphoprotein binding IEA


Pathways (from Reactome)
Pathway description
VxPx cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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