ENSDARG00000014098


Danio rerio

Features
Gene ID: ENSDARG00000014098
  
Biological name :pkd2
  
Synonyms : pkd2 / polycystic kidney disease 2 / Q6IVV8
  
Possible biological names infered from orthology : O35245 / Polycystin-2 / polycystin 2, transient receptor potential cation channel / Q13563
  
Species: Danio rerio
  
Chr. number: 1
Strand: 1
Band:
Gene start: 50538839
Gene end: 50557030
  
Corresponding Affymetrix probe sets:
  
Cross references: Ensembl peptide - ENSDARP00000027024
NCBI entrez gene - 432387     See in Manteia.
RefSeq - NM_001002310
RefSeq Peptide - NP_001002310
swissprot - Q6IVV8
ZFIN ID - ZDB-GENE-040827-4
Ensembl - ENSDARG00000014098
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 PKD2ENSGALG00000010921Gallus gallus
 PKD2ENSG00000118762Homo sapiens
 Pkd2ENSMUSG00000034462Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
pkd2l1 / polycystic kidney disease 2-like 1 / A2A259* / Q9P0L9* / Polycystic kidney disease 2-like 1 protein * / polycystin 2 like 1, transient receptor potential cation channel*ENSDARG0000002250338
pkd1l2a / polycystic kidney disease 1 like 2a / Pkd1l2*ENSDARG0000010534418
pkd1l2b / polycystic kidney disease 1 like 2b / Pkd1l2*ENSDARG0000010121416
pkd1a / polycystic kidney disease 1a / PKD1* / P98161* / polycystin 1, transient receptor potential channel interacting*ENSDARG0000003041713
pkd1b / polycystic kidney disease 1bENSDARG0000003302913
pkd1l2b / polycystic kidney disease 1 like 2b / Pkd1l2*ENSDARG000000881212


Protein motifs (from Interpro)
Interpro ID Name
 IPR002048  EF-hand domain
 IPR003915  Polycystic kidney disease type 2 protein
 IPR011992  EF-hand domain pair
 IPR013122  Polycystin cation channel, PKD1/PKD2


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0001946 lymphangiogenesis IMP
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0003143 embryonic heart tube morphogenesis IMP
 biological_processGO:0003146 heart jogging IMP
 biological_processGO:0003171 atrioventricular valve development IMP
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0007368 determination of left/right symmetry IMP
 biological_processGO:0007507 heart development IMP
 biological_processGO:0009953 dorsal/ventral pattern formation IMP
 biological_processGO:0010882 regulation of cardiac muscle contraction by calcium ion signaling IMP
 biological_processGO:0032965 regulation of collagen biosynthetic process IMP
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0050982 detection of mechanical stimulus IBA
 biological_processGO:0051284 positive regulation of sequestering of calcium ion IMP
 biological_processGO:0061371 determination of heart left/right asymmetry IMP
 biological_processGO:0070121 Kupffer"s vesicle development IMP
 biological_processGO:0070588 calcium ion transmembrane transport ISS
 biological_processGO:0071277 cellular response to calcium ion ISS
 biological_processGO:0071805 potassium ion transmembrane transport ISS
 biological_processGO:0072019 proximal convoluted tubule development IMP
 biological_processGO:0072114 pronephros morphogenesis IMP
 biological_processGO:0097704 cellular response to oscillatory fluid shear stress IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005783 endoplasmic reticulum ISS
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0016323 basolateral plasma membrane IEA
 cellular_componentGO:0016324 apical plasma membrane IEA
 cellular_componentGO:0016328 lateral plasma membrane ISS
 cellular_componentGO:0016529 sarcoplasmic reticulum IEA
 cellular_componentGO:0030017 sarcomere IEA
 cellular_componentGO:0030659 cytoplasmic vesicle membrane IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0033017 sarcoplasmic reticulum membrane IEA
 cellular_componentGO:0042383 sarcolemma IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005262 calcium channel activity IBA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005509 calcium ion binding IEA
 molecular_functionGO:0015271 outward rectifier potassium channel activity ISS
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
VxPx cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000001 Kupffer s vesicle Kupffers vesicle calcium-mediated signaling process quality , abnormal
Kupffers vesicle increased area , abnormal
Kupffers vesicle cytoplasm decreased amount , abnormal
Kupffers vesicle motile cilium absent , abnormal
Kupffers vesicle increased volume , abnormal
Kupffers vesicle decreased volume , abnormal
Kupffers vesicle volume , ameliorated
Kupffers vesicle apical part of cell increased area , abnormal
Kupffers vesicle epithelial cell 3-D shape , abnormal
Show

 ZFA:0000008 brain brain hydrocephalic , abnormal
Show

 ZFA:0000112 gut gut edematous , abnormal
Show

 ZFA:0000114 heart heart edematous , abnormal
heart mislocalised , abnormal
heart morphology , abnormal
Show

 ZFA:0000117 hypoblast hypoblast calcium-mediated signaling process quality , abnormal
Show

 ZFA:0000135 notochord notochord physical object quality , abnormal
Show

 ZFA:0000150 pronephric duct pronephric duct cystic , abnormal
pronephric duct spatial pattern , ameliorated
pronephric duct amount , ameliorated
pronephric duct decreased distribution , abnormal
pronephric duct decreased amount , abnormal
pronephric duct autophagy occurrence , ameliorated
pronephric duct autophagy decreased occurrence , abnormal
pronephric duct increased size , abnormal
pronephric duct distal region obstructed , abnormal
pronephric duct anatomical region has number of leukocyte , ameliorated
pronephric duct anatomical region has extra parts of type leukocyte , abnormal
pronephric duct epithelial cell proliferation occurrence , ameliorated
pronephric duct epithelial cell proliferation increased occurrence , abnormal
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 ZFA:0000151 pronephros pronephros cystic , abnormal
pronephros cystic , ameliorated
pronephros quality , abnormal
pronephros anterior region structure , abnormal
pronephros anterior region truncated , abnormal
pronephros cystic , exacerbated
Show

 ZFA:0000217 inner ear inner ear posterior-most region increased distance pronephric duct anterior-most region, abnormal
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 ZFA:0000298 vent vent morphology , ameliorated
vent malformed , abnormal
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 ZFA:0000330 cloacal chamber cloacal chamber cilium decreased length , abnormal
cloacal chamber cilium decreased amount , abnormal
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 ZFA:0000339 digestive system digestive system morphology , abnormal
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 ZFA:0001055 pronephric duct opening pronephric duct opening decreased size , abnormal
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 ZFA:0001094 whole organism whole organism shape , abnormal
whole organism lethal (sensu genetics) , abnormal
whole organism edematous , abnormal
whole organism curved dorsal , abnormal
whole organism anterior-posterior axis curved dorsal , abnormal
whole organism viability , abnormal
whole organism increased curvature , abnormal
whole organism chromosome increased amount , abnormal
whole organism increased amount , abnormal
whole organism cAMP-dependent protein kinase activity increased occurrence , abnormal
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 ZFA:0001114 head head hydrocephalic , abnormal
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 ZFA:0001115 trunk trunk curved dorsal , abnormal
trunk increased curvature , abnormal
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 ZFA:0001117 post-vent region post-vent region curved , abnormal
post-vent region curved dorsal , abnormal
post-vent region curvature , ameliorated
post-vent region increased curvature , abnormal
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 ZFA:0001288 renal glomerulus renal glomerulus cystic , abnormal
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 ZFA:0001315 atrioventricular canal atrioventricular canal decreased amount , abnormal
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 ZFA:0001557 pronephric glomerulus pronephric glomerulus dilated , abnormal
pronephric glomerulus increased distribution , abnormal
pronephric glomerulus cystic , abnormal
pronephric glomerulus morphology , abnormal
pronephric glomerulus increased size , abnormal
pronephric glomerulus decreased thickness , abnormal
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 ZFA:0001558 pronephric tubule pronephric tubule dilated , abnormal
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 ZFA:0001616 atrioventricular canal endocardium atrioventricular canal endocardium endothelial cell decreased amount , abnormal
atrioventricular canal endocardium decreased amount , abnormal
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 ZFA:0005064 atrioventricular valve atrioventricular valve morphology , abnormal
atrioventricular valve shape , abnormal
Show

 ZFA:0005110 thoracic duct thoracic duct absent , abnormal
thoracic duct malformed , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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