ENSMUSG00000022377


Mus musculus

Features
Gene ID: ENSMUSG00000022377
  
Biological name :Asap1
  
Synonyms : Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 / Asap1 / Q9QWY8
  
Possible biological names infered from orthology : ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 / Q9ULH1
  
Species: Mus musculus
  
Chr. number: 15
Strand: -1
Band: D1
Gene start: 64086857
Gene end: 64382919
  
Corresponding Affymetrix probe sets: 10428998 (MoGene1.0st)   1425572_a_at (Mouse Genome 430 2.0 Array)   1425573_a_at (Mouse Genome 430 2.0 Array)   1435059_at (Mouse Genome 430 2.0 Array)   1438301_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135359
Ensembl peptide - ENSMUSP00000135346
Ensembl peptide - ENSMUSP00000135643
Ensembl peptide - ENSMUSP00000135718
Ensembl peptide - ENSMUSP00000023008
Ensembl peptide - ENSMUSP00000105741
Ensembl peptide - ENSMUSP00000105742
Ensembl peptide - ENSMUSP00000134825
Ensembl peptide - ENSMUSP00000134877
Ensembl peptide - ENSMUSP00000135047
Ensembl peptide - ENSMUSP00000135172
Ensembl peptide - ENSMUSP00000135190
Ensembl peptide - ENSMUSP00000135239
NCBI entrez gene - 13196     See in Manteia.
MGI - MGI:1342335
RefSeq - XM_017316425
RefSeq - NM_001276467
RefSeq - NM_010026
RefSeq - XM_006520392
RefSeq - XM_006520393
RefSeq - XM_006520394
RefSeq - XM_006520395
RefSeq - XM_006520396
RefSeq - XM_006520397
RefSeq - XM_006520398
RefSeq - XM_006520399
RefSeq - XM_006520400
RefSeq - XM_006520401
RefSeq - XM_006520402
RefSeq - XM_006520403
RefSeq - XM_011245448
RefSeq - NM_001276461
RefSeq - NM_001276462
RefSeq - NM_001276463
RefSeq Peptide - NP_034156
RefSeq Peptide - NP_001263392
RefSeq Peptide - NP_001263396
RefSeq Peptide - NP_001263390
RefSeq Peptide - NP_001263391
swissprot - H3BKE6
swissprot - H3BL41
swissprot - E9QN63
swissprot - Q9QWY8
swissprot - E9QMI7
swissprot - E9QMJ1
swissprot - H3BJM7
swissprot - H3BJY2
swissprot - H3BK40
swissprot - H3BKD4
Ensembl - ENSMUSG00000022377
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 asap1aENSDARG00000029463Danio rerio
 asap1bENSDARG00000039729Danio rerio
 ASAP1ENSGALG00000037618Gallus gallus
 ASAP1ENSG00000153317Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Asap2 / Q7SIG6 / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 / O43150* / ArfGAP with SH3 domain, ankyrin repeat and PH domain 2*ENSMUSG0000005263252
Asap3 / Q5U464 / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 / Q8TDY4* / ArfGAP with SH3 domain, ankyrin repeat and PH domain 3*ENSMUSG0000003699535
Acap3 / ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 / Q96P50*ENSMUSG0000002903316
Acap2 / Q6ZQK5 / ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 / Q15057*ENSMUSG0000004907616
Acap1 / Q8K2H4 / ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 / Q15027*ENSMUSG0000000158815
Agap3 / arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform b / Q96P47* / ArfGAP with GTPase domain, ankyrin repeat and PH domain 3*ENSMUSG0000002335314
Agap1 / Q8BXK8 / Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 / Q9UPQ3* / ArfGAP with GTPase domain, ankyrin repeat and PH domain 1*ENSMUSG0000005501314
Agap2 / Q3UHD9 / Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 / Q99490* / ArfGAP with GTPase domain, ankyrin repeat and PH domain 2*ENSMUSG0000002542213


Protein motifs (from Interpro)
Interpro ID Name
 IPR001164  Arf GTPase activating protein
 IPR001452  SH3 domain
 IPR001849  Pleckstrin homology domain
 IPR002110  Ankyrin repeat
 IPR011993  PH-like domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR027267  AH/BAR domain superfamily
 IPR036028  SH3-like domain superfamily
 IPR036770  Ankyrin repeat-containing domain superfamily
 IPR037278  ARFGAP/RecO-like zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0030030 cell projection organization IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0060271 cilium assembly ISO
 biological_processGO:0061000 negative regulation of dendritic spine development IDA
 biological_processGO:0071803 positive regulation of podosome assembly IMP
 biological_processGO:1903527 positive regulation of membrane tubulation IDA
 cellular_componentGO:0002102 podosome IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031253 cell projection membrane IDA
 cellular_componentGO:0043197 dendritic spine IDA
 molecular_functionGO:0001786 phosphatidylserine binding IDA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005546 phosphatidylinositol-4,5-bisphosphate binding IDA
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA
 molecular_functionGO:0045296 cadherin binding ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
VxPx cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003037 Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*  / complex
 ENSMUSG00000005864 Cnga2 / Q62398 / Cyclic nucleotide-gated olfactory channel / Q16280* / cyclic nucleotide gated channel alpha 2*  / complex
 ENSMUSG00000004771 P62492 / Rab11a / RAB11A, member RAS oncogene family / P62491*  / reaction / complex
 ENSMUSG00000037098 Q8CHD8 / Rab11fip3 / Rab11 family-interacting protein 3 / O75154*  / reaction / complex
 ENSMUSG00000022377 Asap1 / Q9QWY8 / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 / Q9ULH1* / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1*  / complex
 ENSMUSG00000030897 Cnga4 / Q3UW12 / Cyclic nucleotide-gated cation channel alpha-4 / Q8IV77* / cyclic nucleotide gated channel alpha 4*  / complex
 ENSMUSG00000032855 Pkd1 / O08852 / Polycystin-1 / P98161* / polycystin 1, transient receptor potential channel interacting*  / complex
 ENSMUSG00000030324 Rho / P15409 / Rhodopsin / P08100*  / complex
 ENSMUSG00000021877 Arf4 / P61750 / ADP-ribosylation factor 4 / P18085*  / complex






 

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