ENSMUSG00000055013


Mus musculus

Features
Gene ID: ENSMUSG00000055013
  
Biological name :Agap1
  
Synonyms : Agap1 / Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 / Q8BXK8
  
Possible biological names infered from orthology : ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 / Q9UPQ3
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: D
Gene start: 89454806
Gene end: 89897617
  
Corresponding Affymetrix probe sets: 10348432 (MoGene1.0st)   1435432_at (Mouse Genome 430 2.0 Array)   1435433_at (Mouse Genome 430 2.0 Array)   1437394_at (Mouse Genome 430 2.0 Array)   1459053_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000027521
Ensembl peptide - ENSMUSP00000148732
Ensembl peptide - ENSMUSP00000148317
Ensembl peptide - ENSMUSP00000140599
Ensembl peptide - ENSMUSP00000074478
NCBI entrez gene - 347722     See in Manteia.
MGI - MGI:2653690
RefSeq - NM_001037136
RefSeq - NM_178119
RefSeq Peptide - NP_001032213
RefSeq Peptide - NP_835220
swissprot - Q8BXK8
swissprot - A0A1D5RMD5
swissprot - A0A1D5RLD2
swissprot - A0A087WRF2
swissprot - E9Q3K3
Ensembl - ENSMUSG00000055013
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 agap1ENSDARG00000062123Danio rerio
 ENSGALG00000004045Gallus gallus
 AGAP1ENSG00000157985Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Agap3 / arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform b / Q96P47* / ArfGAP with GTPase domain, ankyrin repeat and PH domain 3*ENSMUSG0000002335370
Agap2 / Q3UHD9 / Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 / Q99490* / ArfGAP with GTPase domain, ankyrin repeat and PH domain 2*ENSMUSG0000002542253
Acap3 / ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 / Q96P50*ENSMUSG0000002903318
Asap1 / Q9QWY8 / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 / Q9ULH1* / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1*ENSMUSG0000002237718
Acap2 / Q6ZQK5 / ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 / Q15057*ENSMUSG0000004907618
Asap2 / Q7SIG6 / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 / O43150* / ArfGAP with SH3 domain, ankyrin repeat and PH domain 2*ENSMUSG0000005263217
Asap3 / Q5U464 / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 / Q8TDY4* / ArfGAP with SH3 domain, ankyrin repeat and PH domain 3*ENSMUSG0000003699517
Acap1 / Q8K2H4 / ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 / Q15027*ENSMUSG0000000158816


Protein motifs (from Interpro)
Interpro ID Name
 IPR001164  Arf GTPase activating protein
 IPR001806  Small GTPase superfamily
 IPR001849  Pleckstrin homology domain
 IPR002110  Ankyrin repeat
 IPR011993  PH-like domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR020849  Small GTPase superfamily, Ras-type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036770  Ankyrin repeat-containing domain superfamily
 IPR037278  ARFGAP/RecO-like zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISO
 cellular_componentGO:0016020 membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0005543 phospholipid binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000438 abnormal skull morphology "anomalous structure or development of the cranium" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0001289 persistence of hyaloid capillary system "failure of the degeneration of the transient vascular system of the eye during development" [J:49840]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0001303 abnormal lens morphology "malformed transparent structure of the eye responsible for focusing light rays" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:40203]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0001304 cataracts "complete or partial opacity of the lens" [J:65031]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0001307 fused cornea/lens "condition in which the transparent anterior portion of the fibrous coat of the eye is joined to the transparent biconvex cellular refractive structure lying between the iris and vitreous humor of the eye" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0001312 abnormal cornea morphology "malformation or absence of the transparent anterior portion of the fibrous coat of the eye that serves as the chief refractory structure " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0001314 corneal opacity "complete or partial clouding of the cornea" [jte:Janan T. Eppig , Mouse Genome Informatics, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0001322 abnormal iris morphology "structural anomaly of the adjustable membrane, composed of the stroma and pigmented epithelium, located just in front of the crystalline lens within the eye" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0003131 increased erythrocyte count "greater number of the cells in the blood that carry oxygen, red blood cells, per unit" [csmith:Cynthia L. Smith, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0006358 absent pinna reflex "complete failure to respond to an auditory stimulus by a characteristic ear twitch" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0013022 increased Ly6C high monocyte number "increase in the number of monocytes that express high levels of Ly6C and low MHC class II that represent a subset of circulating inflammatory monocytes that are recruited to infected or inflamed tissues" [MGI:Annie_Speak]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

 MP:0013026 decreased Ly6C low monocyte number "decrease in the number of monocytes that express low levels of Ly6C and low MHC class II that represent a subset of patrolling monocytes" [MGI:Annie_Speak]
Show

Allelic Composition: Mbpshi-mld/Mbpshi-mld
Genetic Background: MDB/Dt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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