ENSMUSG00000025422


Mus musculus

Features
Gene ID: ENSMUSG00000025422
  
Biological name :Agap2
  
Synonyms : Agap2 / Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 / Q3UHD9
  
Possible biological names infered from orthology : ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 / Q99490
  
Species: Mus musculus
  
Chr. number: 10
Strand: 1
Band: D3
Gene start: 127075284
Gene end: 127093169
  
Corresponding Affymetrix probe sets: 10366825 (MoGene1.0st)   1419789_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000043466
Ensembl peptide - ENSMUSP00000151946
NCBI entrez gene - 216439     See in Manteia.
MGI - MGI:3580016
RefSeq - XM_006513563
RefSeq - NM_001033263
RefSeq - NM_001301014
RefSeq - XM_006513559
RefSeq - XM_006513561
RefSeq - XM_006513562
RefSeq - XM_006513557
RefSeq - XM_006513558
RefSeq Peptide - NP_001287943
RefSeq Peptide - NP_001028435
swissprot - Q3UHD9
Ensembl - ENSMUSG00000025422
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 agap2ENSDARG00000099874Danio rerio
 AGAP2ENSG00000135439Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Agap3 / arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 isoform b / Q96P47* / ArfGAP with GTPase domain, ankyrin repeat and PH domain 3*ENSMUSG0000002335338
Agap1 / Q8BXK8 / Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1 / Q9UPQ3* / ArfGAP with GTPase domain, ankyrin repeat and PH domain 1*ENSMUSG0000005501338
Acap2 / Q6ZQK5 / ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 / Q15057*ENSMUSG0000004907613
Asap3 / Q5U464 / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 / Q8TDY4* / ArfGAP with SH3 domain, ankyrin repeat and PH domain 3*ENSMUSG0000003699513
Acap3 / ArfGAP with coiled-coil, ankyrin repeat and PH domains 3 / Q96P50*ENSMUSG0000002903313
Acap1 / Q8K2H4 / ArfGAP with coiled-coil, ankyrin repeat and PH domains 1 / Q15027*ENSMUSG0000000158813
Asap1 / Q9QWY8 / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 / Q9ULH1* / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1*ENSMUSG0000002237713
Asap2 / Q7SIG6 / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 / O43150* / ArfGAP with SH3 domain, ankyrin repeat and PH domain 2*ENSMUSG0000005263212


Protein motifs (from Interpro)
Interpro ID Name
 IPR001164  Arf GTPase activating protein
 IPR001806  Small GTPase superfamily
 IPR001849  Pleckstrin homology domain
 IPR002110  Ankyrin repeat
 IPR011993  PH-like domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036770  Ankyrin repeat-containing domain superfamily
 IPR037278  ARFGAP/RecO-like zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0016197 endosomal transport ISO
 biological_processGO:0030036 actin cytoskeleton organization ISO
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0033601 positive regulation of mammary gland epithelial cell proliferation IMP
 biological_processGO:0042177 negative regulation of protein catabolic process ISO
 biological_processGO:0043066 negative regulation of apoptotic process IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process ISO
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0043551 regulation of phosphatidylinositol 3-kinase activity IEA
 biological_processGO:0045860 positive regulation of protein kinase activity ISO
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IMP
 biological_processGO:0060749 mammary gland alveolus development IMP
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005730 nucleolus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion ISO
 cellular_componentGO:0005768 endosome ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity ISO
 molecular_functionGO:0005096 GTPase activator activity ISO
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005524 ATP binding ISO
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0019901 protein kinase binding ISO
 molecular_functionGO:0030295 protein kinase activator activity ISO
 molecular_functionGO:0035014 phosphatidylinositol 3-kinase regulator activity ISO
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001559 hyperglycemia "abnormally high concentration of glucose in the blood; generally refers to a pathological state" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Adam17tm1Rain/Adam17tm1Rain
Genetic Background: involves: C57BL/6

Allelic Composition: Agap2tm1.1Kye/Agap2tm1.1Kye
Genetic Background: Not Specified

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Agap2tm1Kye/Agap2tm1Kye,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002644 decreased circulating triglyceride level "lower than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agap2tm1Kye/Agap2tm1Kye,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Agap2tm1.1Kye/Agap2tm1.1Kye
Genetic Background: Not Specified

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
Show

Allelic Composition: Agap2tm1Kye/Agap2tm1Kye,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Agap2tm1.1Kye/Agap2tm1.1Kye
Genetic Background: Not Specified

 MP:0004047 abnormal milk composition "anomaly in the protein or lipid content of milk" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Pgrtm4.2Lyd/Pgrtm4.2Lyd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Agap2tm1Kye/Agap2tm1Kye,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0005331 insulin resistance "diminished effectiveness of insulin in lowering plasma glucose levels" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:84260, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Agap2tm1Kye/Agap2tm1Kye,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA/2

Allelic Composition: Agap2tm1.1Kye/Agap2tm1.1Kye
Genetic Background: Not Specified

 MP:0006270 abnormal mammary gland growth during lactation "anomaly in the final stage of mammary growth that occurs during the start of lactation" [llw2:Linda Washburn , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pgrtm4.2Lyd/Pgrtm4.2Lyd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0009356 decreased liver triglyceride level "lower than normal concentration of triacylglycerols in the liver" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agap2tm1Kye/Agap2tm1Kye,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0009506 abnormal mammary gland alveolus morphology "any structural anomaly of the sac-like structure of the mammary gland that secretes milk after pregnancy" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pgrtm4.2Lyd/Pgrtm4.2Lyd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0010026 decreased liver cholesterol level "less than normal amount in the liver of the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones; it is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Agap2tm1Kye/Agap2tm1Kye,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0010174 decreased mammary gland epithelium proliferation "decrease in the expansion rate of the cells of the mammary gland epithelium by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pgrtm4.2Lyd/Pgrtm4.2Lyd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0010249 lactation failure "mammary glands do not secrete milk after parturition" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pgrtm4.2Lyd/Pgrtm4.2Lyd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * FVB/N

 MP:0010360 decreased liver free fatty acids level "reduced liver concentration of the fatty acids which occur in plasma as a result of lipolysis in adipose tissue or when plasma triacyglycerols are taken into tissues" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Agap2tm1Kye/Agap2tm1Kye,Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic Background: involves: C57BL/6 * DBA/2

 MP:0014126 increased mammary gland apoptosis "increase in the number of any cells of a mammary gland undergoing programmed cell death" [MGI:Anna]
Show

Allelic Composition: Pgrtm4.2Lyd/Pgrtm4.2Lyd
Genetic Background: involves: 129S4/SvJaeSor * 129S7/SvEvBrd * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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