ENSG00000135439


Homo sapiens

Features
Gene ID: ENSG00000135439
  
Biological name :AGAP2
  
Synonyms : AGAP2 / ArfGAP with GTPase domain, ankyrin repeat and PH domain 2 / Q99490
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: -1
Band: q14.1
Gene start: 57723761
Gene end: 57742157
  
Corresponding Affymetrix probe sets: 206152_at (Human Genome U133 Plus 2.0 Array)   215080_s_at (Human Genome U133 Plus 2.0 Array)   229917_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000449241
Ensembl peptide - ENSP00000257897
Ensembl peptide - ENSP00000328160
Ensembl peptide - ENSP00000446683
NCBI entrez gene - 116986     See in Manteia.
OMIM - 605476
RefSeq - XM_017018772
RefSeq - NM_001122772
RefSeq - NM_014770
RefSeq - XM_005268625
RefSeq - XM_005268626
RefSeq Peptide - NP_001116244
RefSeq Peptide - NP_055585
swissprot - H0YHB1
swissprot - J3KNM6
swissprot - Q99490
swissprot - F8VVT9
swissprot - A0A024RB55
Ensembl - ENSG00000135439
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 agap2ENSDARG00000099874Danio rerio
 Agap2ENSMUSG00000025422Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
AGAP3 / Q96P47 / ArfGAP with GTPase domain, ankyrin repeat and PH domain 3ENSG0000013361238
AGAP1 / Q9UPQ3 / ArfGAP with GTPase domain, ankyrin repeat and PH domain 1ENSG0000015798538
AGAP6 / Q5VW22 / ArfGAP with GTPase domain, ankyrin repeat and PH domain 6ENSG0000020414924
AGAP5 / A6NIR3 / ArfGAP with GTPase domain, ankyrin repeat and PH domain 5ENSG0000017265024
AGAP4 / Q96P64 / ArfGAP with GTPase domain, ankyrin repeat and PH domain 4ENSG0000018823424
AGAP9 / Q5VTM2 / ArfGAP with GTPase domain, ankyrin repeat and PH domain 9ENSG0000020417222
ACAP2 / Q15057 / ArfGAP with coiled-coil, ankyrin repeat and PH domains 2ENSG0000011433113
ASAP3 / Q8TDY4 / ArfGAP with SH3 domain, ankyrin repeat and PH domain 3ENSG0000008828013
ACAP3 / Q96P50 / ArfGAP with coiled-coil, ankyrin repeat and PH domains 3ENSG0000013158413
ACAP1 / Q15027 / ArfGAP with coiled-coil, ankyrin repeat and PH domains 1ENSG0000007281813
ASAP2 / O43150 / ArfGAP with SH3 domain, ankyrin repeat and PH domain 2ENSG0000015169312
ASAP1 / Q9ULH1 / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1ENSG0000015331712


Protein motifs (from Interpro)
Interpro ID Name
 IPR001164  Arf GTPase activating protein
 IPR001806  Small GTPase superfamily
 IPR001849  Pleckstrin homology domain
 IPR002110  Ankyrin repeat
 IPR011993  PH-like domain superfamily
 IPR020683  Ankyrin repeat-containing domain
 IPR027417  P-loop containing nucleoside triphosphate hydrolase
 IPR036770  Ankyrin repeat-containing domain superfamily
 IPR037278  ARFGAP/RecO-like zinc finger


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0032147 activation of protein kinase activity IEA
 biological_processGO:0033601 positive regulation of mammary gland epithelial cell proliferation IEA
 biological_processGO:0042177 negative regulation of protein catabolic process IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043524 negative regulation of neuron apoptotic process IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IEA
 biological_processGO:0046427 positive regulation of JAK-STAT cascade IEA
 biological_processGO:0060749 mammary gland alveolus development IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005634 nucleus IEA
 cellular_componentGO:0005730 nucleolus IDA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IDA
 cellular_componentGO:0016020 membrane HDA
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005515 protein binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0030295 protein kinase activator activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Netrin-1 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000107731 UNC5B / Q8IZJ1 / unc-5 netrin receptor B  / reaction / complex






 

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