ENSMUSG00000030897


Mus musculus

Features
Gene ID: ENSMUSG00000030897
  
Biological name :Cnga4
  
Synonyms : Cnga4 / Cyclic nucleotide-gated cation channel alpha-4 / Q3UW12
  
Possible biological names infered from orthology : cyclic nucleotide gated channel alpha 4 / Q8IV77
  
Species: Mus musculus
  
Chr. number: 7
Strand: 1
Band: E3
Gene start: 105404568
Gene end: 105408742
  
Corresponding Affymetrix probe sets: 10555925 (MoGene1.0st)   1445339_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000033187
Ensembl peptide - ENSMUSP00000147387
NCBI entrez gene - 233649     See in Manteia.
MGI - MGI:2664099
RefSeq - XM_017322183
RefSeq - NM_001033317
RefSeq - XM_006507654
RefSeq - XM_011241744
RefSeq Peptide - NP_001028489
swissprot - Q3UW12
Ensembl - ENSMUSG00000030897
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnga4ENSDARG00000069383Danio rerio
 CNGA4ENSGALG00000022704Gallus gallus
 CNGA4ENSG00000132259Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cnga3 / Q9JJZ8 / Cyclic nucleotide-gated cation channel alpha-3 / Q16281* / cyclic nucleotide gated channel alpha 3*ENSMUSG0000002611450
Cnga2 / Q62398 / Cyclic nucleotide-gated olfactory channel / Q16280* / cyclic nucleotide gated channel alpha 2*ENSMUSG0000000586450
Cnga1 / P29974 / cGMP-gated cation channel alpha-1 / P29973* / cyclic nucleotide gated channel alpha 1*ENSMUSG0000006722049
Cngb1 / cyclic nucleotide gated channel beta 1 / Q14028*ENSMUSG0000003178928
Cngb3 / Q9JJZ9 / Cyclic nucleotide-gated cation channel beta-3 / Q9NQW8* / cyclic nucleotide gated channel beta 3*ENSMUSG0000005649424
Hcn1 / O88704 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 / O60741* / hyperpolarization activated cyclic nucleotide gated potassium channel 1*ENSMUSG0000002173022
Hcn4 / hyperpolarization activated cyclic nucleotide gated potassium channel 4 / Q9Y3Q4*ENSMUSG0000003233822
Hcn2 / O88703 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / Q9UL51* / hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2*ENSMUSG0000002033121
Hcn3 / O88705 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 / Q9P1Z3* / hyperpolarization activated cyclic nucleotide gated potassium channel 3*ENSMUSG0000002805121


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR005821  Ion transport domain
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like
 IPR032406  Cyclic nucleotide-gated channel, C-terminal leucine zipper domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007608 sensory perception of smell IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005216 ion channel activity TAS
 molecular_functionGO:0005249 voltage-gated potassium channel activity IBA
 molecular_functionGO:0030552 cAMP binding IEA


Pathways (from Reactome)
Pathway description
VxPx cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001983 abnormal olfactory system physiology "abnormal function of the system relating to smell " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Slc11a1s/Slc11a1s
Genetic Background: C57BL/6J

 MP:0009562 abnormal odor adaptation "altered ability or failure of the olfactory receptor neurons to adapt to ambient conditions by time-dependent modification in the sensitivity to a given odorant stimulus, as seen in the decline of the sensory response during prolonged odor stimulation; a major mechanism for the rapid calcium-calmodulin-mediated desensitization of the CNG channel" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Slc11a1s/Slc11a1s
Genetic Background: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000003037 Rab8a / P55258 / RAB8A, member RAS oncogene family / P61006*  / complex
 ENSMUSG00000022377 Asap1 / Q9QWY8 / Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 / Q9ULH1* / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1*  / complex
 ENSMUSG00000004771 P62492 / Rab11a / RAB11A, member RAS oncogene family / P62491*  / reaction / complex
 ENSMUSG00000037098 Q8CHD8 / Rab11fip3 / Rab11 family-interacting protein 3 / O75154*  / reaction / complex
 ENSMUSG00000005864 Cnga2 / Q62398 / Cyclic nucleotide-gated olfactory channel / Q16280* / cyclic nucleotide gated channel alpha 2*  / complex
 ENSMUSG00000021877 Arf4 / P61750 / ADP-ribosylation factor 4 / P18085*  / complex / reaction






 

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