ENSMUSG00000028051


Mus musculus

Features
Gene ID: ENSMUSG00000028051
  
Biological name :Hcn3
  
Synonyms : Hcn3 / O88705 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3
  
Possible biological names infered from orthology : hyperpolarization activated cyclic nucleotide gated potassium channel 3 / Q9P1Z3
  
Species: Mus musculus
  
Chr. number: 3
Strand: -1
Band: F1
Gene start: 89146074
Gene end: 89160196
  
Corresponding Affymetrix probe sets: 10499493 (MoGene1.0st)   1451023_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000029686
NCBI entrez gene - 15168     See in Manteia.
MGI - MGI:1298211
RefSeq - NM_008227
RefSeq Peptide - NP_032253
swissprot - B2RRB5
swissprot - O88705
Ensembl - ENSMUSG00000028051
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hcn3ENSDARG00000027192Danio rerio
 HCN3ENSGALG00000033653Gallus gallus
 HCN3ENSG00000143630Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hcn4 / hyperpolarization activated cyclic nucleotide gated potassium channel 4 / Q9Y3Q4*ENSMUSG0000003233868
Hcn2 / O88703 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / Q9UL51* / hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2*ENSMUSG0000002033161
Hcn1 / O88704 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 / O60741* / hyperpolarization activated cyclic nucleotide gated potassium channel 1*ENSMUSG0000002173059
Cnga3 / Q9JJZ8 / Cyclic nucleotide-gated cation channel alpha-3 / Q16281* / cyclic nucleotide gated channel alpha 3*ENSMUSG0000002611418
Cngb1 / cyclic nucleotide gated channel beta 1 / Q14028*ENSMUSG0000003178918
Cnga1 / P29974 / cGMP-gated cation channel alpha-1 / P29973* / cyclic nucleotide gated channel alpha 1*ENSMUSG0000006722017
Cnga2 / Q62398 / Cyclic nucleotide-gated olfactory channel / Q16280* / cyclic nucleotide gated channel alpha 2*ENSMUSG0000000586417
Cnga4 / Q3UW12 / Cyclic nucleotide-gated cation channel alpha-4 / Q8IV77* / cyclic nucleotide gated channel alpha 4*ENSMUSG0000003089716
Cngb3 / Q9JJZ9 / Cyclic nucleotide-gated cation channel beta-3 / Q9NQW8* / cyclic nucleotide gated channel beta 3*ENSMUSG0000005649414


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003938  Potassium channel, voltage-dependent, EAG/ELK/ERG
 IPR005821  Ion transport domain
 IPR013621  Ion transport N-terminal
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport ISO
 biological_processGO:0072718 response to cisplatin IEA
 biological_processGO:1903351 cellular response to dopamine IEA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0044316 cone cell pedicle IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IDA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030552 cAMP binding IEA


Pathways (from Reactome)
Pathway description
HCN channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0003233 prolonged QT interval "increase in the length of time required for ventricular depolarization and repolarization to occur, usually as a result of increased repolarization time" [J:93197, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J

 MP:0010505 abnormal T wave "any anomaly in the T wave which is normally caused by the repolarization (or recovery) of the ventricles" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Grntm1.1Geno/Grntm1.1Geno
Genetic Background: involves: 129 * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000028051 Hcn3 / O88705 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 / Q9P1Z3* / hyperpolarization activated cyclic nucleotide gated potassium channel 3*  / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr