ENSG00000143630


Homo sapiens

Features
Gene ID: ENSG00000143630
  
Biological name :HCN3
  
Synonyms : HCN3 / hyperpolarization activated cyclic nucleotide gated potassium channel 3 / Q9P1Z3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 1
Strand: 1
Band: q22
Gene start: 155277583
Gene end: 155289848
  
Corresponding Affymetrix probe sets: 228741_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000357342
NCBI entrez gene - 57657     See in Manteia.
OMIM - 609973
RefSeq - XM_017001918
RefSeq - NM_020897
RefSeq - XM_011509817
RefSeq - XM_011509818
RefSeq - XM_011509816
RefSeq Peptide - NP_065948
swissprot - Q9P1Z3
Ensembl - ENSG00000143630
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hcn3ENSDARG00000027192Danio rerio
 HCN3ENSGALG00000033653Gallus gallus
 Hcn3ENSMUSG00000028051Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HCN4 / Q9Y3Q4 / hyperpolarization activated cyclic nucleotide gated potassium channel 4ENSG0000013862269
HCN2 / Q9UL51 / hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2ENSG0000009982262
HCN1 / O60741 / hyperpolarization activated cyclic nucleotide gated potassium channel 1ENSG0000016458860
CNGA3 / Q16281 / cyclic nucleotide gated channel alpha 3ENSG0000014419118
CNGB1 / Q14028 / cyclic nucleotide gated channel beta 1ENSG0000007072918
CNGA1 / P29973 / cyclic nucleotide gated channel alpha 1ENSG0000019851517
CNGA2 / Q16280 / cyclic nucleotide gated channel alpha 2ENSG0000018386217
CNGA4 / Q8IV77 / cyclic nucleotide gated channel alpha 4ENSG0000013225916
CNGB3 / Q9NQW8 / cyclic nucleotide gated channel beta 3ENSG0000017028916


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003938  Potassium channel, voltage-dependent, EAG/ELK/ERG
 IPR005821  Ion transport domain
 IPR013621  Ion transport N-terminal
 IPR014710  RmlC-like jelly roll fold
 IPR018490  Cyclic nucleotide-binding-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IMP
 biological_processGO:0042391 regulation of membrane potential IMP
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IMP
 biological_processGO:0072718 response to cisplatin IEA
 biological_processGO:1903351 cellular response to dopamine IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0044316 cone cell pedicle IEA
 cellular_componentGO:0045202 synapse IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity IMP
 molecular_functionGO:0005249 voltage-gated potassium channel activity IMP
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030552 cAMP binding IEA


Pathways (from Reactome)
Pathway description
HCN channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000143630 HCN3 / Q9P1Z3 / hyperpolarization activated cyclic nucleotide gated potassium channel 3  / complex






 

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