ENSG00000099822


Homo sapiens

Features
Gene ID: ENSG00000099822
  
Biological name :HCN2
  
Synonyms : HCN2 / hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 / Q9UL51
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 19
Strand: 1
Band: p13.3
Gene start: 589893
Gene end: 617159
  
Corresponding Affymetrix probe sets: 207592_s_at (Human Genome U133 Plus 2.0 Array)   214893_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000251287
NCBI entrez gene - 610     See in Manteia.
OMIM - 602781
RefSeq - NM_001194
RefSeq Peptide - NP_001185
swissprot - Q9UL51
Ensembl - ENSG00000099822
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 HCN2ENSGALG00000001342Gallus gallus
 Hcn2ENSMUSG00000020331Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
HCN4 / Q9Y3Q4 / hyperpolarization activated cyclic nucleotide gated potassium channel 4ENSG0000013862266
HCN1 / O60741 / hyperpolarization activated cyclic nucleotide gated potassium channel 1ENSG0000016458858
HCN3 / Q9P1Z3 / hyperpolarization activated cyclic nucleotide gated potassium channel 3ENSG0000014363054
CNGA3 / Q16281 / cyclic nucleotide gated channel alpha 3ENSG0000014419117
CNGB1 / Q14028 / cyclic nucleotide gated channel beta 1ENSG0000007072916
CNGA1 / P29973 / cyclic nucleotide gated channel alpha 1ENSG0000019851515
CNGA2 / Q16280 / cyclic nucleotide gated channel alpha 2ENSG0000018386215
CNGB3 / Q9NQW8 / cyclic nucleotide gated channel beta 3ENSG0000017028915
CNGA4 / Q8IV77 / cyclic nucleotide gated channel alpha 4ENSG0000013225914


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003938  Potassium channel, voltage-dependent, EAG/ELK/ERG
 IPR005821  Ion transport domain
 IPR013621  Ion transport N-terminal
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IMP
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071320 cellular response to cAMP IDA
 biological_processGO:0071321 cellular response to cGMP IDA
 biological_processGO:0071805 potassium ion transmembrane transport IMP
 biological_processGO:0086012 membrane depolarization during cardiac muscle cell action potential IC
 biological_processGO:0098719 sodium ion import across plasma membrane IDA
 biological_processGO:1990573 potassium ion import across plasma membrane IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0008076 voltage-gated potassium channel complex TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0098855 HCN channel complex IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005222 intracellular cAMP activated cation channel activity IDA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity IMP
 molecular_functionGO:0005249 voltage-gated potassium channel activity IMP
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
HCN channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000099822 HCN2 / Q9UL51 / hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2  / complex






 

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