ENSG00000132259


Homo sapiens

Features
Gene ID: ENSG00000132259
  
Biological name :CNGA4
  
Synonyms : CNGA4 / cyclic nucleotide gated channel alpha 4 / Q8IV77
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 11
Strand: 1
Band: p15.4
Gene start: 6234765
Gene end: 6244429
  
Corresponding Affymetrix probe sets: 1562273_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000433399
Ensembl peptide - ENSP00000369268
NCBI entrez gene - 1262     See in Manteia.
OMIM - 609472
RefSeq - XM_017017219
RefSeq - NM_001037329
RefSeq - XM_017017217
RefSeq - XM_017017218
RefSeq Peptide - NP_001032406
swissprot - B4DYQ8
swissprot - Q8IV77
Ensembl - ENSG00000132259
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnga4ENSDARG00000069383Danio rerio
 CNGA4ENSGALG00000022704Gallus gallus
 Cnga4ENSMUSG00000030897Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CNGA3 / Q16281 / cyclic nucleotide gated channel alpha 3ENSG0000014419151
CNGA1 / P29973 / cyclic nucleotide gated channel alpha 1ENSG0000019851550
CNGA2 / Q16280 / cyclic nucleotide gated channel alpha 2ENSG0000018386250
CNGB1 / Q14028 / cyclic nucleotide gated channel beta 1ENSG0000007072928
CNGB3 / Q9NQW8 / cyclic nucleotide gated channel beta 3ENSG0000017028927
HCN3 / Q9P1Z3 / hyperpolarization activated cyclic nucleotide gated potassium channel 3ENSG0000014363022
HCN4 / Q9Y3Q4 / hyperpolarization activated cyclic nucleotide gated potassium channel 4ENSG0000013862222
HCN2 / Q9UL51 / hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2ENSG0000009982221
HCN1 / O60741 / hyperpolarization activated cyclic nucleotide gated potassium channel 1ENSG0000016458821


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR005821  Ion transport domain
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like
 IPR032406  Cyclic nucleotide-gated channel, C-terminal leucine zipper domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0007608 sensory perception of smell IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030660 Golgi-associated vesicle membrane TAS
 cellular_componentGO:0060170 ciliary membrane TAS
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IBA
 molecular_functionGO:0030552 cAMP binding IEA


Pathways (from Reactome)
Pathway description
VxPx cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000070729 CNGB1 / Q14028 / cyclic nucleotide gated channel beta 1  / complex
 ENSG00000103769 P62491 / RAB11A / RAB11A, member RAS oncogene family  / complex / reaction
 ENSG00000090565 O75154 / RAB11FIP3 / RAB11 family interacting protein 3  / complex / reaction
 ENSG00000167461 RAB8A / P61006 / RAB8A, member RAS oncogene family  / complex / reaction
 ENSG00000168374 ARF4 / P18085 / ADP ribosylation factor 4  / complex / reaction
 ENSG00000183862 CNGA2 / Q16280 / cyclic nucleotide gated channel alpha 2  / complex
 ENSG00000153317 ASAP1 / Q9ULH1 / ArfGAP with SH3 domain, ankyrin repeat and PH domain 1  / complex / reaction
 ENSG00000127328 Q96QF0 / RAB3IP / RAB3A interacting protein  / reaction / complex






 

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