ENSMUSG00000026114


Mus musculus

Features
Gene ID: ENSMUSG00000026114
  
Biological name :Cnga3
  
Synonyms : Cnga3 / Cyclic nucleotide-gated cation channel alpha-3 / Q9JJZ8
  
Possible biological names infered from orthology : cyclic nucleotide gated channel alpha 3 / Q16281
  
Species: Mus musculus
  
Chr. number: 1
Strand: 1
Band: B
Gene start: 37214434
Gene end: 37263384
  
Corresponding Affymetrix probe sets: 10345571 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000142175
Ensembl peptide - ENSMUSP00000142235
Ensembl peptide - ENSMUSP00000027288
Ensembl peptide - ENSMUSP00000142075
NCBI entrez gene - 12790     See in Manteia.
MGI - MGI:1341818
RefSeq - XM_017313745
RefSeq - XM_017313748
RefSeq - NM_001282010
RefSeq - NM_009918
RefSeq Peptide - NP_001268939
RefSeq Peptide - NP_034048
swissprot - Q9JJZ8
swissprot - A0A0A6YY14
swissprot - A0A0A6YXW9
Ensembl - ENSMUSG00000026114
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cnga3aENSDARG00000070726Danio rerio
 cnga3bENSDARG00000012297Danio rerio
 CNGA3ENSGALG00000039826Gallus gallus
 CNGA3ENSG00000144191Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cnga2 / Q62398 / Cyclic nucleotide-gated olfactory channel / Q16280* / cyclic nucleotide gated channel alpha 2*ENSMUSG0000000586463
Cnga1 / P29974 / cGMP-gated cation channel alpha-1 / P29973* / cyclic nucleotide gated channel alpha 1*ENSMUSG0000006722059
Cnga4 / Q3UW12 / Cyclic nucleotide-gated cation channel alpha-4 / Q8IV77* / cyclic nucleotide gated channel alpha 4*ENSMUSG0000003089743
Cngb1 / cyclic nucleotide gated channel beta 1 / Q14028*ENSMUSG0000003178929
Cngb3 / Q9JJZ9 / Cyclic nucleotide-gated cation channel beta-3 / Q9NQW8* / cyclic nucleotide gated channel beta 3*ENSMUSG0000005649426
Hcn4 / hyperpolarization activated cyclic nucleotide gated potassium channel 4 / Q9Y3Q4*ENSMUSG0000003233823
Hcn1 / O88704 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 / O60741* / hyperpolarization activated cyclic nucleotide gated potassium channel 1*ENSMUSG0000002173022
Hcn2 / O88703 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / Q9UL51* / hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2*ENSMUSG0000002033122
Hcn3 / O88705 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 / Q9P1Z3* / hyperpolarization activated cyclic nucleotide gated potassium channel 3*ENSMUSG0000002805120


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR005821  Ion transport domain
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like
 IPR032406  Cyclic nucleotide-gated channel, C-terminal leucine zipper domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport ISO
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0031960 response to corticosteroid IEA
 biological_processGO:0032026 response to magnesium ion IEA
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0046549 retinal cone cell development IMP
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0051591 response to cAMP IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0001750 photoreceptor outer segment ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005886 plasma membrane IDA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0042622 photoreceptor outer segment membrane IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:1902495 transmembrane transporter complex ISO
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005221 intracellular cyclic nucleotide activated cation channel activity IPI
 molecular_functionGO:0005223 intracellular cGMP activated cation channel activity ISO
 molecular_functionGO:0005249 voltage-gated potassium channel activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008022 protein C-terminus binding IEA
 molecular_functionGO:0030553 cGMP binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001005 abnormal rod morphology "structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0001006 abnormal cone morphology "structural or developmental anomaly of the retinal receptors that give rise to color vision" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Aiptm1Bra/Aip+
Genetic Background: Not Specified

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

 MP:0001983 abnormal olfactory system physiology "abnormal function of the system relating to smell " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0002003 meiotic pupils "charcterized by contraction of the pupils " [J:17194]
Show

Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0002638 abnormal pupillary reflex "alterations or failure of the pupil to change in diamater as a reflex response to any stimulus" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, cml:Cathleen M. Lutz , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aiptm1Bra/Aip+
Genetic Background: Not Specified

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

 MP:0005551 abnormal eye electrophysiology "abnormal function of the eye as determined through electrophysiological recordings from single cells or summary recordings from multiple cells (e.g. electroretinogram)" [NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

 MP:0006068 abnormal horizontal cell morphology "anomalous structure of the laterally interconnecting neurons in the outer plexiform layer" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

 MP:0006069 abnormal retinal neuronal layer morphology "malformation in any of the neuronal layers that make up the retina, including the ganglion cell, inner plexiform, inner nuclear, outer plexiform, outer nuclear layers, the inner and outer segments" [smb:Susan M Bello, Mouse Genome Informatics Curator, Gray s Anatomy:ISBN 0-914294-08-3]
Show

Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

 MP:0006074 abnormal retinal rod bipolar cell morphology "anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
Show

Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

 MP:0006149 blurred vision "loss of visiual acuity or ability to distinguish small details" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cbstm1Unc/Cbstm1Unc,Tg(Mt1-CBS)25Waku/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cbstm1Unc/Cbstm1Unc,Tg(Mt1-CBS)25Waku/0
Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

 MP:0008449 abnormal retinal cone cell outer segment morphology "any structural anomaly of the retinal cone cell region in which the visual pigment rhodopsin is in invaginations of the cell membrane" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Lipetm1Gam/Lipetm1Gam
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Cnga3cpfl5/Cnga3cpfl5
Genetic Background: B6.RHJ-Cnga3cpfl5/BocJ

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rhotm1Phm/Rhotm1Phm
Genetic Background: involves: C57BL/6

 MP:0008584 photoreceptor outer segment degeneration "retrogressive pathologic change in the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cnga3cpfl5/Cnga3cpfl5
Genetic Background: B6.RHJ-Cnga3cpfl5/BocJ

 MP:0009943 abnormal olfactory bulb periglomerular cell morphology "any structural anomaly of the small neuron in the glomerular layer of the olfactory bulb whose dendrites arborize within a glomerulus, where it receives synaptic input from olfactory receptor cell axon terminals, and also engages in dendrodendritic interactions with mitral and tufted cell dendrites; uses both GABA and dopamine as a neurotransmitter" [NLX:nlx_cell_091202 "NeuroLex.org"]
Show

Allelic Composition: Ltbp3m1Btlr/Ltbp3m1Btlr
Genetic Background: either: C57BL/6J-Ltbp3m1Btlr or (involves: C3H/HeJ * C57BL/6J)

 MP:0011831 abnormal visual contrast sensitivity "any abnormality in the ability to distinguish between increments of light versus dark" [MGI:smb]
Show

Allelic Composition: Cnga3cpfl5/Cnga3cpfl5
Genetic Background: B6.RHJ-Cnga3cpfl5/BocJ

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Cnga3cpfl5/Cnga3cpfl5
Genetic Background: B6.RHJ-Cnga3cpfl5/BocJ

 MP:0020470 shortened circadian behavior period "decrease in the cycle length of a behavior expressed when exposed to constant conditions without temporal cues" [MGI:smb]
Show

Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

 MP:0020476 abnormal circardian behavior entrainment "anomaly in the synchronization of a circadian behavior to environmental time cues such as light" [GO:0009649]
Show

Allelic Composition: Cnga3tm1Biel/Cnga3tm1Biel,Rpe65tm1Tmr/Rpe65tm1Tmr
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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