ENSMUSG00000056494


Mus musculus

Features
Gene ID: ENSMUSG00000056494
  
Biological name :Cngb3
  
Synonyms : Cngb3 / Cyclic nucleotide-gated cation channel beta-3 / Q9JJZ9
  
Possible biological names infered from orthology : cyclic nucleotide gated channel beta 3 / Q9NQW8
  
Species: Mus musculus
  
Chr. number: 4
Strand: 1
Band: A3
Gene start: 19280850
Gene end: 19510623
  
Corresponding Affymetrix probe sets: 10503464 (MoGene1.0st)   1450492_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000100064
NCBI entrez gene - 30952     See in Manteia.
MGI - MGI:1353562
RefSeq - NM_013927
RefSeq Peptide - NP_038955
swissprot - Q9JJZ9
Ensembl - ENSMUSG00000056494
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cngb3.1ENSDARG00000101225Danio rerio
 cngb3.2ENSDARG00000101368Danio rerio
 CNGB3ENSGALG00000037644Gallus gallus
 CNGB3ENSG00000170289Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cngb1 / cyclic nucleotide gated channel beta 1 / Q14028*ENSMUSG0000003178948
Cnga3 / Q9JJZ8 / Cyclic nucleotide-gated cation channel alpha-3 / Q16281* / cyclic nucleotide gated channel alpha 3*ENSMUSG0000002611425
Cnga2 / Q62398 / Cyclic nucleotide-gated olfactory channel / Q16280* / cyclic nucleotide gated channel alpha 2*ENSMUSG0000000586424
Cnga1 / P29974 / cGMP-gated cation channel alpha-1 / P29973* / cyclic nucleotide gated channel alpha 1*ENSMUSG0000006722024
Cnga4 / Q3UW12 / Cyclic nucleotide-gated cation channel alpha-4 / Q8IV77* / cyclic nucleotide gated channel alpha 4*ENSMUSG0000003089720
Hcn4 / hyperpolarization activated cyclic nucleotide gated potassium channel 4 / Q9Y3Q4*ENSMUSG0000003233818
Hcn2 / O88703 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / Q9UL51* / hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2*ENSMUSG0000002033117
Hcn1 / O88704 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 / O60741* / hyperpolarization activated cyclic nucleotide gated potassium channel 1*ENSMUSG0000002173016
Hcn3 / O88705 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 / Q9P1Z3* / hyperpolarization activated cyclic nucleotide gated potassium channel 3*ENSMUSG0000002805115


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like
 IPR032943  Cyclic nucleotide-gated cation channel beta-3


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0009187 cyclic nucleotide metabolic process IC
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0050896 response to stimulus IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0001750 photoreceptor outer segment IDA
 cellular_componentGO:0005886 plasma membrane IC
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:1902495 transmembrane transporter complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005221 intracellular cyclic nucleotide activated cation channel activity IEA
 molecular_functionGO:0005223 intracellular cGMP activated cation channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IBA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0030553 cGMP binding ISO


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

 MP:0008444 retinal cone cell degeneration "a retrogressive impairment of function or destruction of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

 MP:0008446 decreased retinal cone cell number "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

 MP:0008449 abnormal retinal cone cell outer segment morphology "any structural anomaly of the retinal cone cell region in which the visual pigment rhodopsin is in invaginations of the cell membrane" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

 MP:0008586 disorganized photoreceptor outer segment "derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

 MP:0030005 increased retinal apoptosis "increase in the number of cells in the retina undergoing programmed cell death" [MGI:anna]
Show

Allelic Composition: Aplntm1Tq/Y
Genetic Background: B6.129S6-Aplntm1Tq

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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