ENSMUSG00000032338


Mus musculus

Features
Gene ID: ENSMUSG00000032338
  
Biological name :Hcn4
  
Synonyms : Hcn4 / hyperpolarization activated cyclic nucleotide gated potassium channel 4
  
Possible biological names infered from orthology : Q9Y3Q4
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: B
Gene start: 58823412
Gene end: 58863175
  
Corresponding Affymetrix probe sets: 10585851 (MoGene1.0st)   
  
Cross references: Ensembl peptide - ENSMUSP00000034889
NCBI entrez gene - 330953     See in Manteia.
MGI - MGI:1298209
RefSeq - NM_001081192
RefSeq Peptide - NP_001074661
swissprot - B2RY58
Ensembl - ENSMUSG00000032338
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CABZ01086574.1ENSDARG00000116404Danio rerio
 hcn4ENSDARG00000061685Danio rerio
 hcn4lENSDARG00000074419Danio rerio
 HCN4ENSGALG00000001764Gallus gallus
 HCN4ENSG00000138622Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hcn2 / O88703 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / Q9UL51* / hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2*ENSMUSG0000002033149
Hcn1 / O88704 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 / O60741* / hyperpolarization activated cyclic nucleotide gated potassium channel 1*ENSMUSG0000002173047
Hcn3 / O88705 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 / Q9P1Z3* / hyperpolarization activated cyclic nucleotide gated potassium channel 3*ENSMUSG0000002805144
Cngb1 / cyclic nucleotide gated channel beta 1 / Q14028*ENSMUSG0000003178916
Cnga3 / Q9JJZ8 / Cyclic nucleotide-gated cation channel alpha-3 / Q16281* / cyclic nucleotide gated channel alpha 3*ENSMUSG0000002611413
Cnga1 / P29974 / cGMP-gated cation channel alpha-1 / P29973* / cyclic nucleotide gated channel alpha 1*ENSMUSG0000006722012
Cnga2 / Q62398 / Cyclic nucleotide-gated olfactory channel / Q16280* / cyclic nucleotide gated channel alpha 2*ENSMUSG0000000586412
Cngb3 / Q9JJZ9 / Cyclic nucleotide-gated cation channel beta-3 / Q9NQW8* / cyclic nucleotide gated channel beta 3*ENSMUSG0000005649411
Cnga4 / Q3UW12 / Cyclic nucleotide-gated cation channel alpha-4 / Q8IV77* / cyclic nucleotide gated channel alpha 4*ENSMUSG0000003089710


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003938  Potassium channel, voltage-dependent, EAG/ELK/ERG
 IPR005821  Ion transport domain
 IPR013621  Ion transport N-terminal
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like
 IPR030173  Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002027 regulation of heart rate IEA
 biological_processGO:0003254 regulation of membrane depolarization IEA
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport IEA
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0055117 regulation of cardiac muscle contraction IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071321 cellular response to cGMP IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0086015 SA node cell action potential IEA
 biological_processGO:0086046 membrane depolarization during SA node cell action potential IEA
 biological_processGO:0086091 regulation of heart rate by cardiac conduction IEA
 biological_processGO:0098719 sodium ion import across plasma membrane IEA
 biological_processGO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction IEA
 biological_processGO:1990573 potassium ion import across plasma membrane IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0031226 intrinsic component of plasma membrane IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 cellular_componentGO:0098855 HCN channel complex IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005222 intracellular cAMP activated cation channel activity IEA
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IEA
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0030552 cAMP binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0086041 voltage-gated potassium channel activity involved in SA node cell action potential depolarization IEA


Pathways (from Reactome)
Pathway description
HCN channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001629 abnormal heart rate "greater than or fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
Show

Allelic Composition: Amhtm3.1Bhr/Amhtm3.1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

 MP:0001636 irregular heartbeat "uneven timing of heart contraction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:33038]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Hcn4tm1(cre/ERT2)Anlu/Hcn4+
Genetic Background: involves: 129S/SvEv

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Mycntm1Fwa/Mycntm1Fwa
Genetic Background: involves: 129S/SvEv

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Hcn4tm1(cre/ERT2)Anlu/Hcn4+
Genetic Background: involves: 129S/SvEv

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Hcn4tm1Jsr/Hcn4tm1(cre/ERT2)Anlu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hcn4tm1Sev/?
Genetic Background: Not Specified

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Eml1heco/Eml1heco
Genetic Background: involves: C57BL/6 * NOR

 MP:0002741 small olfactory bulb "reduced size of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [J:79871]
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Allelic Composition: Eml1heco/Eml1heco
Genetic Background: involves: C57BL/6 * NOR

 MP:0003137 abnormal impulse conducting system conduction "anomaly in the impulse-conducting system composed of modified cardiac muscle and having the power of spontaneous rhythmicity and conduction more highly developed than the rest of the heart" [hdene:Howard Dene , Mouse Genome Informatics Curator, J:92050, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Hcn4tm1Jsr/Hcn4tm1(cre/ERT2)Anlu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hcn4tm1.1Ggc/Hcn4tm1.1Ggc,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0003141 cardiac fibrosis "formation of fibrous tissue within the heart often resulting from inflammation or injury " [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Hcn4tm1(cre/ERT2)Anlu/Hcn4+
Genetic Background: involves: 129S/SvEv

 MP:0003896 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarisation and the beginning of ventricular depolarisation" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Hcn4tm1(cre/ERT2)Anlu/Hcn4+
Genetic Background: involves: 129S/SvEv

 MP:0003928 increased heart rate variability "increased variation of beat-to-beat intervals of the heart, usually indicitive of a healthy heart" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Hcn4tm1(cre/ERT2)Anlu/Hcn4+
Genetic Background: involves: 129S/SvEv

 MP:0004115 abnormal sinoatrial node morphology "structural anomaly in the small mass of modified cardiac muscle fibers located at the junction of the superior vena cava and the right atruim that is the source of contraction impulses for the heart" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Hcn4tm1(cre/ERT2)Anlu/Hcn4+
Genetic Background: involves: 129S/SvEv

 MP:0005140 decreased cardiac muscle contractility "inability or reduced ability of the heart muscle to shorten or to develop increased tension" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: involves: 101/El * C3H/El

 MP:0005333 decreased heart rate "fewer than average resting heart beats per minute" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, J:84764]
Show

Allelic Composition: Ldhaa-m1Neu/Ldhaa-m1Neu
Genetic Background: involves: 101/El * C3H/El

Allelic Composition: Hcn4tm1Rsei/Hcn4+
Genetic Background: B6.Cg-Hcn4tm1Rsei

Allelic Composition: Hcn4tm1Jsr/Hcn4tm1(cre/ERT2)Anlu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

Allelic Composition: Hcn4tm1.1Ggc/Hcn4tm1.1Ggc,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Hcn4tm1(cre/ERT2)Anlu/Hcn4+
Genetic Background: involves: 129S/SvEv

 MP:0006142 abnormal sinoatrial node conduction "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Hcn4tm1.1Ggc/Hcn4tm1.1Ggc,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

 MP:0009948 abnormal olfactory bulb glomerular layer morphology 
Show

Allelic Composition: Eml1heco/Eml1heco
Genetic Background: involves: C57BL/6 * NOR

 MP:0010519 atrioventricular block "a partial or complete obstruction of the impulse that originates in the atria or sinoatrial node from reaching or transmitting through the atrioventricular node to the ventricles" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hcn4tm1.1Ggc/Hcn4tm1.1Ggc,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

Allelic Composition: Gt(ROSA)26Sortm1(DTA)Jpmb/Gt(ROSA)26Sor+,Hcn4tm1(cre/ERT2)Anlu/Hcn4+
Genetic Background: involves: 129S/SvEv

 MP:0010520 sinoatrial block "a partial or complete obstruction of the impulse leaving the sinoatrial node preventing it from activating atrial muscle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Hcn4tm1Jsr/Hcn4tm1(cre/ERT2)Anlu
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0011092 complete embryonic lethality "death of all organisms of a given genotype in a population within the embryonic period prior to organogenesis (Mus: prior to E14)" [MGI:csmith]
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Allelic Composition: Tyrm4Btlr/Tyrm4Btlr
Genetic Background: C57BL/6J-Tyrm4Btlr

Allelic Composition: Hcn4tm3Sev/Hcn4tm3Sev
Genetic Background: involves: Black Swiss * C57BL/6J

 MP:0011098 complete embryonic lethality during organogenesis "death of all organisms of a given genotype in a population between embryo turning and the completion of organogenesis (Mus: E9 to less than E14)" [MGI:csmith]
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Allelic Composition: Amhtm3.1Bhr/Amhtm3.1Bhr
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Hcn4tm1.1Jsr/Hcn4tm1.1Jsr
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Hcn4tm1Rsei/Hcn4tm1Rsei
Genetic Background: B6.Cg-Hcn4tm1Rsei

 MP:0011953 prolonged PQ interval "increase in the length of time between the beginning of atrial depolarization and the end of atrial repolarization (or recovery), measured by the interval from the beginning of the P wave to the end of the Q wave" [MPD:Molly]
Show

Allelic Composition: Hcn4tm1.1Ggc/Hcn4tm1.1Ggc,A1cfTg(Myh6-cre/Esr1*)1Jmk/0
Genetic Background: involves: 129S/SvEv * C57BL/6 * FVB/N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000032338 Hcn4 / hyperpolarization activated cyclic nucleotide gated potassium channel 4 / Q9Y3Q4*  / complex






 

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