ENSMUSG00000021730


Mus musculus

Features
Gene ID: ENSMUSG00000021730
  
Biological name :Hcn1
  
Synonyms : Hcn1 / O88704 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
  
Possible biological names infered from orthology : hyperpolarization activated cyclic nucleotide gated potassium channel 1 / O60741
  
Species: Mus musculus
  
Chr. number: 13
Strand: 1
Band: D2.3
Gene start: 117602320
Gene end: 117987418
  
Corresponding Affymetrix probe sets: 10407337 (MoGene1.0st)   1450193_at (Mouse Genome 430 2.0 Array)   1453807_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000006991
NCBI entrez gene - 15165     See in Manteia.
MGI - MGI:1096392
RefSeq - NM_010408
RefSeq Peptide - NP_034538
swissprot - O88704
Ensembl - ENSMUSG00000021730
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 hcn1ENSDARG00000104480Danio rerio
 HCN1ENSGALG00000014875Gallus gallus
 HCN1ENSG00000164588Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Hcn4 / hyperpolarization activated cyclic nucleotide gated potassium channel 4 / Q9Y3Q4*ENSMUSG0000003233862
Hcn2 / O88703 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / Q9UL51* / hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2*ENSMUSG0000002033157
Hcn3 / O88705 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 / Q9P1Z3* / hyperpolarization activated cyclic nucleotide gated potassium channel 3*ENSMUSG0000002805151
Cnga3 / Q9JJZ8 / Cyclic nucleotide-gated cation channel alpha-3 / Q16281* / cyclic nucleotide gated channel alpha 3*ENSMUSG0000002611416
Cnga1 / P29974 / cGMP-gated cation channel alpha-1 / P29973* / cyclic nucleotide gated channel alpha 1*ENSMUSG0000006722016
Cngb1 / cyclic nucleotide gated channel beta 1 / Q14028*ENSMUSG0000003178916
Cnga2 / Q62398 / Cyclic nucleotide-gated olfactory channel / Q16280* / cyclic nucleotide gated channel alpha 2*ENSMUSG0000000586416
Cnga4 / Q3UW12 / Cyclic nucleotide-gated cation channel alpha-4 / Q8IV77* / cyclic nucleotide gated channel alpha 4*ENSMUSG0000003089714
Cngb3 / Q9JJZ9 / Cyclic nucleotide-gated cation channel beta-3 / Q9NQW8* / cyclic nucleotide gated channel beta 3*ENSMUSG0000005649413


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR003938  Potassium channel, voltage-dependent, EAG/ELK/ERG
 IPR005821  Ion transport domain
 IPR013621  Ion transport N-terminal
 IPR014710  RmlC-like jelly roll fold
 IPR015943  WD40/YVTN repeat-like-containing domain superfamily
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like
 IPR030169  Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006811 ion transport IEA
 biological_processGO:0006813 potassium ion transport IEA
 biological_processGO:0006814 sodium ion transport IEA
 biological_processGO:0034765 regulation of ion transmembrane transport IEA
 biological_processGO:0035725 sodium ion transmembrane transport ISO
 biological_processGO:0042391 regulation of membrane potential IEA
 biological_processGO:0045176 apical protein localization IMP
 biological_processGO:0046549 retinal cone cell development IMP
 biological_processGO:0051289 protein homotetramerization IEA
 biological_processGO:0055085 transmembrane transport IEA
 biological_processGO:0071320 cellular response to cAMP IEA
 biological_processGO:0071805 potassium ion transmembrane transport ISO
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane ISS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030424 axon IDA
 cellular_componentGO:0030425 dendrite IDA
 cellular_componentGO:0098855 HCN channel complex IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005216 ion channel activity IEA
 molecular_functionGO:0005222 intracellular cAMP activated cation channel activity IMP
 molecular_functionGO:0005244 voltage-gated ion channel activity IEA
 molecular_functionGO:0005248 voltage-gated sodium channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IMP
 molecular_functionGO:0005267 potassium channel activity IEA
 molecular_functionGO:0005272 sodium channel activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0022843 voltage-gated cation channel activity IEA
 molecular_functionGO:0030552 cAMP binding ISO
 molecular_functionGO:0042802 identical protein binding IPI


Pathways (from Reactome)
Pathway description
HCN channels


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000819 abnormal olfactory bulb morphology "malformation or absence of the forebrain region that coordinates neuronal signaling involved in the perception of smell; it receives input from the sensory neurons and outputs to the olfactory cortex" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, Principles of Neural Science:ISBN 0-8385-8034-3, J:16461]
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Allelic Composition: Pdgfbtm3.1Cbet/Pdgfbtm3.1Cbet,Tg(Fabp4-lacZ)4Mosh/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Lmx1bIcst/Lmx1b+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0001970 abnormal pain threshold "increased or decreased average level of perception of pain" [J:17792]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0002063 abnormal learning/memory/conditioning "altered ability to receive, store or recall informational stimuli" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmx1bIcst/Lmx1b+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmx1bIcst/Lmx1b+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0002272 abnormal nervous system electrophysiology "anomaly in the function of the nervous system as it relates to electrical phenomena" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apba3tm1.2Ski/Apba3tm1.2Ski
Genetic Background: B6.129-Apba3tm1.2Ski

 MP:0002739 abnormal olfactory bulb development "abnormality in the progression of the formation of the olfactory bulb" [J:65380, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Hcn1tm2Kndl/Hcn1tm2Kndl,Olfr160tm6Mom/Olfr160tm6Mom
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0002797 thigmotaxis "preference of a mouse for the side walls of a cage or box; usually an indicator of increased anxiety response" [J:56814]
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Allelic Composition: Lmx1bIcst/Lmx1b+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0002804 abnormal motor learning "defects in the ability to repeat a motor task requiring well coordinated movements and balance; measures cerebellar dependent learning" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Lmx1bIcst/Lmx1b+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0002807 abnormal eye blink conditioning behavior "defects in the ability of an animal to learn to blink in anticipation of an aversive stimulus (e.g., an airpuff to the eyelid) following repeated pairings with a neutral stimulus (e.g., a tone); such learning is only adaptive if the animal is able to learn the precise timing between the conditioned and unconditioned stimuli " [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Lmx1bIcst/Lmx1b+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0003360 depression-related behavior 
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Allelic Composition: Prkcdtm1Qxu/Prkcdtm1Qxu
Genetic Background: B6.129P2-Prkcdtm1Qxu

 MP:0003393 decreased cardiac output "reduction in the blood volume pumped by each ventricle per minute" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Magi2tm1Key/Magi2tm1Key
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003928 increased heart rate variability "increased variation of beat-to-beat intervals of the heart, usually indicitive of a healthy heart" [RGD:Rat Genome Database submission]
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Allelic Composition: Magi2tm1Key/Magi2tm1Key
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004085 abnormal heartbeat "anomaly in the appearance of regularly spaced contractions of the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Magi2tm1Key/Magi2tm1Key
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004215 abnormal myocardial fiber physiology "anomaly in the function of the multinucleated muscle cells of the heart" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Lmx1bIcst/Lmx1b+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Lmx1bIcst/Lmx1b+
Genetic Background: involves: BALB/cAnN * C3H/HeN

 MP:0006092 abnormal olfactory neuron morphology "malformation in the neurons that are activated by specific odorants" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92950]
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Allelic Composition: Hcn1tm2Kndl/Hcn1tm2Kndl,Olfr160tm6Mom/Olfr160tm6Mom
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0006142 abnormal sinoatrial node conduction "anomaly in the generation or transfer of electrical impulses that trigger contraction of the atria and ventricles" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Magi2tm1Key/Magi2tm1Key
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009946 abnormal olfactory bulb layer morphology "any structural anomaly of the laminar structure of the forebrain region that coordinates neuronal signaling involved in the perception of smell" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Hcn1tm2Kndl/Hcn1tm2Kndl,Olfr160tm6Mom/Olfr160tm6Mom
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0009948 abnormal olfactory bulb glomerular layer morphology 
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Allelic Composition: Hcn1tm2Kndl/Hcn1tm2Kndl,Olfr160tm6Mom/Olfr160tm6Mom
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0010057 abnormal olfactory bulb outer nerve layer moprhology "any strucutral anomaly of the outerpost layer of the olfactory bulb; consists primarily of olfactory afferent axons and ensheathing glia" [PMID:12533617]
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Allelic Composition: Hcn1tm2Kndl/Hcn1tm2Kndl,Olfr160tm6Mom/Olfr160tm6Mom
Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * C57BL/6J

 MP:0010504 abnormal RR interval "anomaly in the length of the interval between an R wave and the next R wave; the RR interval is the inverse of the heart rate" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Magi2tm1Key/Magi2tm1Key
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010520 sinoatrial block "a partial or complete obstruction of the impulse leaving the sinoatrial node preventing it from activating atrial muscle" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Magi2tm1Key/Magi2tm1Key
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010637 sinus bradycardia "a type of decreased heart rhythm in which fewer than the normal number of impulses arise from the sinoatrial (SA) node" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Magi2tm1Key/Magi2tm1Key
Genetic Background: involves: 129S4/SvJae * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000021730 Hcn1 / O88704 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 / O60741* / hyperpolarization activated cyclic nucleotide gated potassium channel 1*  / complex






 

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