ENSMUSG00000031789


Mus musculus

Features
Gene ID: ENSMUSG00000031789
  
Biological name :Cngb1
  
Synonyms : Cngb1 / cyclic nucleotide gated channel beta 1
  
Possible biological names infered from orthology : Q14028
  
Species: Mus musculus
  
Chr. number: 8
Strand: -1
Band: C5
Gene start: 95239045
Gene end: 95306585
  
Corresponding Affymetrix probe sets: 10580829 (MoGene1.0st)   10580850 (MoGene1.0st)   10580852 (MoGene1.0st)   10580854 (MoGene1.0st)   1451549_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000113750
Ensembl peptide - ENSMUSP00000148564
Ensembl peptide - ENSMUSP00000148391
Ensembl peptide - ENSMUSP00000148367
Ensembl peptide - ENSMUSP00000148290
Ensembl peptide - ENSMUSP00000139246
Ensembl peptide - ENSMUSP00000113827
Ensembl peptide - ENSMUSP00000090956
Ensembl peptide - ENSMUSP00000112437
NCBI entrez gene - 333329     See in Manteia.
MGI - MGI:2664102
RefSeq - XM_006531140
RefSeq - NM_001195413
RefSeq - NM_145601
RefSeq Peptide - NP_663576
RefSeq Peptide - NP_001182342
swissprot - E1AZ71
swissprot - V9GXN8
swissprot - E9PXX0
swissprot - Q91WA8
swissprot - A0A1D5RLZ4
swissprot - A0A1D5RLH2
swissprot - A0A1D5RLJ2
swissprot - A0A1D5RLA7
Ensembl - ENSMUSG00000031789
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cngb1aENSDARG00000068242Danio rerio
 si:dkey-44k1.5ENSDARG00000042107Danio rerio
 CNGB1ENSGALG00000042647Gallus gallus
 CNGB1ENSG00000070729Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cngb3 / Q9JJZ9 / Cyclic nucleotide-gated cation channel beta-3 / Q9NQW8* / cyclic nucleotide gated channel beta 3*ENSMUSG0000005649425
Cnga1 / P29974 / cGMP-gated cation channel alpha-1 / P29973* / cyclic nucleotide gated channel alpha 1*ENSMUSG0000006722015
Cnga2 / Q62398 / Cyclic nucleotide-gated olfactory channel / Q16280* / cyclic nucleotide gated channel alpha 2*ENSMUSG0000000586414
Hcn4 / hyperpolarization activated cyclic nucleotide gated potassium channel 4 / Q9Y3Q4*ENSMUSG0000003233814
Cnga3 / Q9JJZ8 / Cyclic nucleotide-gated cation channel alpha-3 / Q16281* / cyclic nucleotide gated channel alpha 3*ENSMUSG0000002611414
Cnga4 / Q3UW12 / Cyclic nucleotide-gated cation channel alpha-4 / Q8IV77* / cyclic nucleotide gated channel alpha 4*ENSMUSG0000003089712
Hcn1 / O88704 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 / O60741* / hyperpolarization activated cyclic nucleotide gated potassium channel 1*ENSMUSG0000002173011
Hcn3 / O88705 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 / Q9P1Z3* / hyperpolarization activated cyclic nucleotide gated potassium channel 3*ENSMUSG0000002805111
Hcn2 / O88703 / Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 / Q9UL51* / hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2*ENSMUSG0000002033111


Protein motifs (from Interpro)
Interpro ID Name
 IPR000595  Cyclic nucleotide-binding domain
 IPR014710  RmlC-like jelly roll fold
 IPR018488  Cyclic nucleotide-binding, conserved site
 IPR018490  Cyclic nucleotide-binding-like
 IPR032944  Cyclic nucleotide-gated cation channel beta-1


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001895 retina homeostasis IEA
 biological_processGO:0006812 cation transport IEA
 biological_processGO:0007601 visual perception IEA
 biological_processGO:0007602 phototransduction IMP
 biological_processGO:0007608 sensory perception of smell IMP
 biological_processGO:0033365 protein localization to organelle IMP
 biological_processGO:0034220 ion transmembrane transport IEA
 biological_processGO:0035845 photoreceptor cell outer segment organization IMP
 biological_processGO:0042391 regulation of membrane potential IBA
 biological_processGO:0045494 photoreceptor cell maintenance IMP
 biological_processGO:0050908 detection of light stimulus involved in visual perception IEA
 biological_processGO:0051290 protein heterotetramerization IEA
 biological_processGO:0051480 regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0071805 potassium ion transmembrane transport IEA
 biological_processGO:0098655 cation transmembrane transport IEA
 cellular_componentGO:0001750 photoreceptor outer segment IDA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005887 integral component of plasma membrane IBA
 cellular_componentGO:0016020 membrane IDA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0017071 intracellular cyclic nucleotide activated cation channel complex IEA
 cellular_componentGO:0043195 terminal bouton IEA
 cellular_componentGO:1902495 transmembrane transporter complex IEA
 molecular_functionGO:0005221 intracellular cyclic nucleotide activated cation channel activity IEA
 molecular_functionGO:0005222 intracellular cAMP activated cation channel activity IEA
 molecular_functionGO:0005223 intracellular cGMP activated cation channel activity IEA
 molecular_functionGO:0005249 voltage-gated potassium channel activity IBA
 molecular_functionGO:0030553 cGMP binding IEA
 molecular_functionGO:0043855 cyclic nucleotide-gated ion channel activity IMP


Pathways (from Reactome)
Pathway description
Activation of the phototransduction cascade
Inactivation, recovery and regulation of the phototransduction cascade
VxPx cargo-targeting to cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001005 abnormal rod morphology "structural or developmental anomaly of the photoreceptors that contain rhodopsin" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ikbkgtm1Mak/Y
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

 MP:0001327 reduced retinal photoreceptor cell number "fewer than the expected number of rods and/or cones" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

 MP:0002082 postnatal lethality "premature death anytime after postnatal day 1 to weaning age (3 weeks)" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

 MP:0003463 abnormal single cell response "altered values from controls obtained upon extra- or intracellular recordings from single cells" [Nmice:Neuromice Consortium Submission]
Show

Allelic Composition: Hbb-bh1tm1Fier/Hbb-bh1tm1Fier,Hbb-ytm2.2Fier/Hbb-ytm2.2Fier
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

Allelic Composition: Cngb1tm1Sjpi/Cngb1tm1Sjpi
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Cngb1tm1.1Glf/Cngb1tm1.1Glf
Genetic Background: involves: 129/Sv * C57BL/6

Allelic Composition: Cngb1tm1.1Glf/Cngb1tm1.1Glf,Guca1a/Guca1btm1Jnc/Guca1a/Guca1btm1Jnc
Genetic Background: involves: 129/Sv * 129S1/Sv * C57BL/6

 MP:0004811 abnormal neuron physiology "anomalous function of the cells of the nervous system that receive, conduct, and transmit impulses" [MESH:National Library of Medicine_Medical Subject Headings]
Show

Allelic Composition: Hbb-bh1tm1Fier/Hbb-bh1tm1Fier,Hbb-ytm2.2Fier/Hbb-ytm2.2Fier
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cd8b1M1Btlr/Cd8b1+
Genetic Background: C57BL/6J-Cd8b1M1Btlr

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Hbb-bh1tm1Fier/Hbb-bh1tm1Fier,Hbb-ytm2.2Fier/Hbb-ytm2.2Fier
Genetic Background: involves: 129S1/Sv * 129X1/SvJ

 MP:0006068 abnormal horizontal cell morphology "anomalous structure of the laterally interconnecting neurons in the outer plexiform layer" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

 MP:0006074 abnormal retinal rod bipolar cell morphology "anomalous structure of the bipolar cells that function in low light and transmit signals only through amacrine cells" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:92623]
Show

Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

Allelic Composition: Cngb1tm1Sjpi/Cngb1tm1Sjpi
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008456 abnormal retinal rod cell outer segment morphology "any strucutral anomaly of the retinal rod cell region which contains stacks of membranous discs separate from the outer cell membrane that are rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ren1tm3Gom/Ren1+
Genetic Background: 129S6/SvEvTac-Ren1tm3Gom

Allelic Composition: Cngb1tm1Sjpi/Cngb1tm1Sjpi
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Cd8b1M1Btlr/Cd8b1+
Genetic Background: C57BL/6J-Cd8b1M1Btlr

 MP:0011965 decreased total retina thickness "decreased width of the retina through the center plane" [MGI:csmith]
Show

Allelic Composition: Cd8b1M1Btlr/Cd8b1+
Genetic Background: C57BL/6J-Cd8b1M1Btlr

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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