ENSMUSG00000025035


Mus musculus

Features
Gene ID: ENSMUSG00000025035
  
Biological name :Arl3
  
Synonyms : ADP-ribosylation factor-like protein 3 / Arl3 / Q9WUL7
  
Possible biological names infered from orthology : ADP ribosylation factor like GTPase 3 / P36405
  
Species: Mus musculus
  
Chr. number: 19
Strand: -1
Band: C3
Gene start: 46531109
Gene end: 46573085
  
Corresponding Affymetrix probe sets: 10468231 (MoGene1.0st)   1450706_a_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000026009
NCBI entrez gene - 56350     See in Manteia.
MGI - MGI:1929699
RefSeq - XM_006527223
RefSeq - NM_019718
RefSeq Peptide - NP_062692
swissprot - Q543P7
swissprot - Q9WUL7
Ensembl - ENSMUSG00000025035
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arl3ENSDARG00000071409Danio rerio
 zgc:110197ENSDARG00000056794Danio rerio
 ARL3ENSGALG00000008049Gallus gallus
 ARL3ENSG00000138175Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arl2 / Q9D0J4 / ADP-ribosylation factor-like protein 2 / P36404* / ARL2-SNX15* / ADP ribosylation factor like GTPase 2* / ARL2-SNX15 readthrough (NMD candidate)*ENSMUSG0000002494453
Arf1 / P84078 / ADP-ribosylation factor 1 ENSMUSG0000004807645
Arf2 / Q8BSL7 / ADP-ribosylation factor 2 ENSMUSG0000006242145
Arf3 / P61205 / ADP-ribosylation factor 3 / P61204*ENSMUSG0000005185345
Arf6 / P62331 / ADP-ribosylation factor 6 / P62330*ENSMUSG0000004414743
Arf4 / P61750 / ADP-ribosylation factor 4 / P18085*ENSMUSG0000002187742
Arf5 / P84084 / ADP-ribosylation factor 5 / P84085*ENSMUSG0000002044042
Arl14 / ADP ribosylation factor like GTPase 14 / Q8N4G2*ENSMUSG0000009820741
Q8BGX0 / Trim23 / E3 ubiquitin-protein ligase TRIM23 / P36406* / tripartite motif containing 23*ENSMUSG0000002171239
Arl11 / Q6P3A9 / ADP-ribosylation factor-like protein 11 / Q969Q4* / ADP ribosylation factor like GTPase 11*ENSMUSG0000004315736
Arl8b / Q9CQW2 / ADP-ribosylation factor-like protein 8B / Q9NVJ2* / ADP ribosylation factor like GTPase 8B*ENSMUSG0000003010532
Arl15 / Q8BGR6 / ADP-ribosylation factor-like protein 15 / Q9NXU5* / ADP ribosylation factor like GTPase 15*ENSMUSG0000004234832
Arl8a / Q8VEH3 / ADP-ribosylation factor-like protein 8A / Q96BM9* / ADP ribosylation factor like GTPase 8A*ENSMUSG0000002642631


Protein motifs (from Interpro)
Interpro ID Name
 IPR005225  Small GTP-binding protein domain
 IPR006689  Small GTPase superfamily, ARF/SAR type
 IPR024156  Small GTPase superfamily, ARF type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000281 mitotic cytokinesis IEA
 biological_processGO:0001822 kidney development IMP
 biological_processGO:0006892 post-Golgi vesicle-mediated transport IEA
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007224 smoothened signaling pathway IMP
 biological_processGO:0007264 small GTPase mediated signal transduction ISS
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0042073 intraciliary transport IMP
 biological_processGO:0042461 photoreceptor cell development IMP
 biological_processGO:0051301 cell division IEA
 biological_processGO:0060271 cilium assembly IEA
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005634 nucleus ISO
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005813 centrosome IEA
 cellular_componentGO:0005815 microtubule organizing center IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0005876 spindle microtubule IEA
 cellular_componentGO:0005881 cytoplasmic microtubule IEA
 cellular_componentGO:0005929 cilium ISS
 cellular_componentGO:0005930 axoneme IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0032391 photoreceptor connecting cilium IEA
 cellular_componentGO:0035869 ciliary transition zone IDA
 cellular_componentGO:0036064 ciliary basal body IDA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0003924 GTPase activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005525 GTP binding ISO
 molecular_functionGO:0008017 microtubule binding IEA
 molecular_functionGO:0019003 GDP binding IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Trafficking of myristoylated proteins to the cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000527 abnormal kidney development "anomalous differentiation of the paired organs responsible for urine secretion" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

 MP:0001265 reduced body size "smaller than average body weight, height and/or length of an organism compared to controls" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:23170]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

 MP:0001270 distended abdomen "abdomen appears curved outward or swollen; can be due to skeletal axial defects, enlarged visceral organs or megacolon" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

 MP:0001944 abnormal pancreas morphology "malformation of the organ that secretes pancreatic juice into the duodenum and secretes glucagon and insulin into the bloodstream" [il:Ira Lu , Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

 MP:0002705 dilated renal tubules "enlarged lumens of the loops of Henle and/or collecting ducts of the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

 MP:0002928 abnormal bile duct morphology "malformation of the channels that secrete bile from the liver to the gall bladder and intestines" [RGD:Rat Genome Database submission, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

 MP:0002929 abnormal bile duct development "incomplete or aberrant differentiation of the channels that secrete bile from the liver to the gall bladder and intestines" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, RGD:Rat Genome Database submission]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

 MP:0003068 enlarged kidney "larger than average size of the kidney" [J:86005, pvb:Pierre Vanden Borre, Mouse Genome Informatics Curator]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

 MP:0003254 bile duct inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the bile ducts" [ncbi:Matthew Mailman, NCBI request, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

 MP:0003336 pancreatic cysts "the appearance of fluid-filled sacs within the pancreas" [ncbi:Matthew Mailman, NCBI request]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

 MP:0003675 kidney cysts "abnormal membranous sacs in any portion of the pair of organs responsible for urine secretion" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

 MP:0004247 small pancreas "decrease of the size of the pancreas compared to controls" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

 MP:0008585 absent photoreceptor outer segment "absence of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

 MP:0009343 dilated gall bladder "abnormal distention of the gall bladder due to accumulation of fluid or bile" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

 MP:0009498 abnormal extrahepatic bile duct morphology "any structural anomaly of the passages external to the liver for the conveyance of bile" [MESH:A03.159.183.079]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

 MP:0011085 complete postnatal lethality "premature death anytime between the neonatal period and weaning age of all organisms of a given genotype in a population (Mus: P1 to approximately 3 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

 MP:0011101 partial prenatal lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and birth (Mus: approximately E18.5)" [MGI:csmith]
Show

Allelic Composition: Kcnj6wv/Kcnj6wv
Genetic Background: involves: C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000060090 Rp2 / Q9EPK2 / Protein XRP2 / O75695* / RP2, ARL3 GTPase activating protein*  / complex / reaction
 ENSMUSG00000046562 Q8C4B4 / Unc119b / unc-119 lipid binding chaperone B / A6NIH7*  / complex / reaction
 ENSMUSG00000032558 Nphp3 / Q7TNH6 / Nephrocystin-3 / Q7Z494* / NPHP3-ACAD11* / NPHP3-ACAD11 readthrough (NMD candidate)*  / reaction / complex
 ENSMUSG00000062563 Cys1 / cystin 1 / Q717R9*  / complex / reaction






 

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