ENSMUSG00000060090


Mus musculus

Features
Gene ID: ENSMUSG00000060090
  
Biological name :Rp2
  
Synonyms : Protein XRP2 / Q9EPK2 / Rp2
  
Possible biological names infered from orthology : O75695 / RP2, ARL3 GTPase activating protein
  
Species: Mus musculus
  
Chr. number: X
Strand: 1
Band: A1.3
Gene start: 20364481
Gene end: 20405653
  
Corresponding Affymetrix probe sets: 10598839 (MoGene1.0st)   1419585_at (Mouse Genome 430 2.0 Array)   1419586_at (Mouse Genome 430 2.0 Array)   1419587_s_at (Mouse Genome 430 2.0 Array)   1434061_at (Mouse Genome 430 2.0 Array)   1454816_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000138724
Ensembl peptide - ENSMUSP00000111045
Ensembl peptide - ENSMUSP00000111049
Ensembl peptide - ENSMUSP00000033372
Ensembl peptide - ENSMUSP00000138352
NCBI entrez gene - 19889     See in Manteia.
MGI - MGI:1277953
RefSeq - XM_017318439
RefSeq - NM_001290643
RefSeq - NM_001290644
RefSeq - NM_133669
RefSeq Peptide - NP_001277573
RefSeq Peptide - NP_598430
RefSeq Peptide - NP_001277572
swissprot - Q9EPK2
Ensembl - ENSMUSG00000060090
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 rp2ENSDARG00000044339Danio rerio
 RP2ENSGALG00000016728Gallus gallus
 RP2ENSG00000102218Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Tbcc / tubulin-specific chaperone C / Q15814* / tubulin folding cofactor C*ENSMUSG0000003643016


Protein motifs (from Interpro)
Interpro ID Name
 IPR006599  CARP motif
 IPR012945  Tubulin binding cofactor C-like domain
 IPR017901  C-CAP/cofactor C-like domain
 IPR034907  Nucleoside diphosphate kinase-like domain
 IPR036223  Adenylate cyclase-associated CAP, C-terminal superfamily
 IPR036850  Nucleoside diphosphate kinase-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006892 post-Golgi vesicle-mediated transport ISO
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 cellular_componentGO:0005654 nucleoplasm ISO
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005794 Golgi apparatus IDA
 cellular_componentGO:0005814 centriole IDA
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016604 nuclear body ISO
 cellular_componentGO:0031410 cytoplasmic vesicle ISO
 cellular_componentGO:0036064 ciliary basal body ISO
 cellular_componentGO:0042995 cell projection IEA
 cellular_componentGO:1990075 periciliary membrane compartment IDA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005096 GTPase activator activity ISO
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Trafficking of myristoylated proteins to the cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001004 abnormal photoreceptor morphology "structural or developmental anomaly of the receptors sensitive to light " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL

Allelic Composition: Rp2tm1.2Asw/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Svep1tm1b(EUCOMM)Hmgu/Svep1tm1b(EUCOMM)Hmgu
Genetic Background: B6N(Cg)-Svep1tm1b(EUCOMM)Hmgu/J

Allelic Composition: Rp2Gt(EUCJ0183f04)Hmgu/Rp2Gt(EUCJ0183f04)Hmgu
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0002090 abnormal vision "inability or decreased ability to see " [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Svep1tm1b(EUCOMM)Hmgu/Svep1tm1b(EUCOMM)Hmgu
Genetic Background: B6N(Cg)-Svep1tm1b(EUCOMM)Hmgu/J

Allelic Composition: Rp2Gt(EUCJ0183f04)Hmgu/Rp2Gt(EUCJ0183f04)Hmgu
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0004021 abnormal rod electrophysiology "anomaly in the function of dark adapted vision mediated by the rods" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL

Allelic Composition: Rp2tm1.2Asw/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0004022 abnormal cone electrophysiology "anomaly in the function of light adapted vision mediated by the cones" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL

Allelic Composition: Rp2tm1.2Asw/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0005253 abnormal eye physiology "anomalous function and/or activity of the ocular system or any of its parts" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Rp2Gt(EUCJ0183f04)Hmgu/Rp2Gt(EUCJ0183f04)Hmgu
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0008446 decreased retinal cone cell number "reduced number of one of the photoreceptor cell types in the retina, in which the photopigment is in invaginations of the cell membrane of the outer segment" [MESH:A08.663.650.650.670.100, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL

Allelic Composition: Rp2tm1.2Asw/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008515 thin retinal outer nuclear layer "reduced thickness of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL

Allelic Composition: Rp2tm1.2Asw/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0008586 disorganized photoreceptor outer segment "derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL

Allelic Composition: Rp2tm1.2Asw/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

 MP:0012029 abnormal electroretinogram waveform feature "any anomaly in the pattern of the graphic record of the integrated ensemble response from many vision related neuronal and glial populations as a consequence of the serial processing within the retina, represented as changes in voltage over time after visual photonic stimulation" [MGI:csmith]
Show

Allelic Composition: Svep1tm1b(EUCOMM)Hmgu/Svep1tm1b(EUCOMM)Hmgu
Genetic Background: B6N(Cg)-Svep1tm1b(EUCOMM)Hmgu/J

Allelic Composition: Rp2Gt(EUCJ0183f04)Hmgu/Rp2Gt(EUCJ0183f04)Hmgu
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0012031 abnormal b wave amplitude "anomaly in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Rp2Gt(EUCJ0183f04)Hmgu/Rp2Gt(EUCJ0183f04)Hmgu
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0012143 decreased a wave amplitude "reduction in the size (height or maximum displacement) of the a wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL

Allelic Composition: Rp2tm1.2Asw/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Rp2Gt(EUCJ0183f04)Hmgu/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Rp2Gt(EUCJ0183f04)Hmgu/Rp2Gt(EUCJ0183f04)Hmgu
Genetic Background: involves: C57BL/6 * C57BL/6N

 MP:0012144 decreased b wave amplitude "reduction in the size (height or maximum displacement) of the b wave as measured in the electroretinogram" [MGI:csmith]
Show

Allelic Composition: Mnx1tm4(cre)Tmj/Mnx1+,Rhot1tm1.1Jmsu/Rhot1tm1.2Jmsu
Genetic Background: involves: 129 * 129S1/Sv * C57BL/6 * SJL

Allelic Composition: Rp2tm1.2Asw/Y
Genetic Background: involves: 129S/SvEv * C57BL/6

Allelic Composition: Rp2Gt(EUCJ0183f04)Hmgu/Y
Genetic Background: involves: C57BL/6 * C57BL/6N

Allelic Composition: Rp2Gt(EUCJ0183f04)Hmgu/Rp2Gt(EUCJ0183f04)Hmgu
Genetic Background: involves: C57BL/6 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000025035 Arl3 / Q9WUL7 / ADP-ribosylation factor-like protein 3 / P36405* / ADP ribosylation factor like GTPase 3*  / complex / reaction
 ENSMUSG00000060090 Rp2 / Q9EPK2 / Protein XRP2 / O75695* / RP2, ARL3 GTPase activating protein*  / reaction
 ENSMUSG00000046562 Q8C4B4 / Unc119b / unc-119 lipid binding chaperone B / A6NIH7*  / reaction / complex






 

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