ENSDARG00000044339


Danio rerio

Features
Gene ID: ENSDARG00000044339
  
Biological name :rp2
  
Synonyms : F1QC45 / rp2 / RP2, ARL3 GTPase activating protein
  
Possible biological names infered from orthology : O75695 / Protein XRP2 / Q9EPK2
  
Species: Danio rerio
  
Chr. number: 6
Strand: -1
Band:
Gene start: 37513911
Gene end: 37525879
  
Corresponding Affymetrix probe sets: Dr.9089.1.S1_at (Zebrafish Array)   NM_213446_at (Zebrafish Genome Array with custom cdf files)   
  
Cross references: Ensembl peptide - ENSDARP00000120363
Ensembl peptide - ENSDARP00000155269
NCBI entrez gene - 406755     See in Manteia.
RefSeq - NM_213446
RefSeq - XM_005165978
RefSeq Peptide - NP_998611
swissprot - F1QC45
ZFIN ID - ZDB-GENE-040426-2795
Ensembl - ENSDARG00000044339
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 RP2ENSGALG00000016728Gallus gallus
 RP2ENSG00000102218Homo sapiens
 Rp2ENSMUSG00000060090Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
tbcc / tubulin folding cofactor C / Q15814* / tubulin-specific chaperone C*ENSDARG0000002291816


Protein motifs (from Interpro)
Interpro ID Name
 IPR006599  CARP motif
 IPR012945  Tubulin binding cofactor C-like domain
 IPR013912  Adenylate cyclase-associated CAP, C-terminal
 IPR017901  C-CAP/cofactor C-like domain
 IPR034907  Nucleoside diphosphate kinase-like domain


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001947 heart looping IMP
 biological_processGO:0010842 retina layer formation IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0035845 photoreceptor cell outer segment organization IMP
 biological_processGO:0042461 photoreceptor cell development IMP
 biological_processGO:0043547 positive regulation of GTPase activity IEA
 biological_processGO:0045494 photoreceptor cell maintenance IMP
 biological_processGO:0048793 pronephros development IMP
 biological_processGO:0060041 retina development in camera-type eye IMP
 biological_processGO:0061371 determination of heart left/right asymmetry IMP
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0005929 cilium IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0042995 cell projection IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005096 GTPase activator activity IEA
 molecular_functionGO:0005525 GTP binding IEA


Pathways (from Reactome)
Pathway description
Trafficking of myristoylated proteins to the cilium


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 ZFA:0000008 brain brain hydrocephalic , abnormal
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 ZFA:0000024 retinal ganglion cell layer retinal ganglion cell layer absent , abnormal
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 ZFA:0000042 midbrain hindbrain boundary midbrain hindbrain boundary blurry , abnormal
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 ZFA:0000054 pericardium pericardium edematous , abnormal
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 ZFA:0000106 extension extension decreased width , abnormal
extension decreased size , abnormal
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 ZFA:0000107 eye eye decreased size , abnormal
eye opaque , abnormal
eye shape , abnormal
eye degenerate , abnormal
eye absent , abnormal
eye decreased amount , abnormal
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 ZFA:0000114 heart heart malformed , abnormal
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 ZFA:0000119 retinal inner nuclear layer retinal inner nuclear layer absent , abnormal
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 ZFA:0000143 retinal photoreceptor layer retinal photoreceptor layer decreased amount , abnormal
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 ZFA:0000150 pronephric duct pronephric duct cystic , abnormal
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 ZFA:0001058 caudal fin caudal fin bent , abnormal
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 ZFA:0001065 lateral mesoderm lateral mesoderm bilateral symmetry , abnormal
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 ZFA:0001117 post-vent region post-vent region curved , abnormal
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 ZFA:0001464 retinal outer nuclear layer retinal outer nuclear layer absent , abnormal
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 ZFA:0001466 photoreceptor outer segment layer photoreceptor outer segment layer decreased thickness , abnormal
photoreceptor outer segment layer decreased distribution , abnormal
photoreceptor outer segment layer photoreceptor outer segment shortened , abnormal
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 ZFA:0009262 retinal cone cell retinal cone cell photoreceptor outer segment absent , abnormal
retinal cone cell photoreceptor outer segment decreased length , abnormal
retinal cone cell photoreceptor outer segment increased length , abnormal
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 ZFA:0009275 retinal rod cell retinal rod cell photoreceptor outer segment absent , abnormal
retinal rod cell degeneration , abnormal
retinal rod cell photoreceptor outer segment decreased length , abnormal
retinal rod cell photoreceptor outer segment decreased size , abnormal
retinal rod cell photoreceptor outer segment absence due to degeneration , abnormal
retinal rod cell photoreceptor disc membrane disorganized , abnormal
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSDARG00000009629 Q90Z08 / unc119.1 / unc-119 homolog 1 / A6NIH7* / Q8C4B4* / UNC119B* / unc-119 lipid binding chaperone B*  / complex / reaction
 ENSDARG00000056794 zgc:110197 / ARL3 (1 of many) / ARL3* / P36405* / Q9WUL7* / ADP ribosylation factor like GTPase 3* / ADP-ribosylation factor-like protein 3 *  / complex / reaction
 ENSDARG00000071409 arl3 / Q1MTE5 / ADP-ribosylation factor-like 3 / P36405* / Q9WUL7* / ADP ribosylation factor like GTPase 3* / ADP-ribosylation factor-like protein 3 *  / complex / reaction
 ENSDARG00000044339 rp2 / F1QC45 / RP2, ARL3 GTPase activating protein / O75695* / Q9EPK2* / Protein XRP2 *  / reaction






 

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