ENSMUSG00000030105


Mus musculus

Features
Gene ID: ENSMUSG00000030105
  
Biological name :Arl8b
  
Synonyms : ADP-ribosylation factor-like protein 8B / Arl8b / Q9CQW2
  
Possible biological names infered from orthology : ADP ribosylation factor like GTPase 8B / Q9NVJ2
  
Species: Mus musculus
  
Chr. number: 6
Strand: 1
Band: E2
Gene start: 108783099
Gene end: 108825278
  
Corresponding Affymetrix probe sets: 10540480 (MoGene1.0st)   1418819_at (Mouse Genome 430 2.0 Array)   1428137_at (Mouse Genome 430 2.0 Array)   1428138_s_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000145035
Ensembl peptide - ENSMUSP00000032196
NCBI entrez gene - 67166     See in Manteia.
MGI - MGI:1914416
RefSeq - NM_026011
RefSeq Peptide - NP_080287
swissprot - A0A0N4SVB8
swissprot - Q9CQW2
Ensembl - ENSMUSG00000030105
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 arl8baENSDARG00000006915Danio rerio
 ARL8BENSGALG00000008314Gallus gallus
 ARL8BENSG00000134108Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Arl8a / Q8VEH3 / ADP-ribosylation factor-like protein 8A / Q96BM9* / ADP ribosylation factor like GTPase 8A*ENSMUSG0000002642691
Arf6 / P62331 / ADP-ribosylation factor 6 / P62330*ENSMUSG0000004414733
Arf2 / Q8BSL7 / ADP-ribosylation factor 2 ENSMUSG0000006242133
Arf3 / P61205 / ADP-ribosylation factor 3 / P61204*ENSMUSG0000005185332
Arf1 / P84078 / ADP-ribosylation factor 1 ENSMUSG0000004807632
Arl3 / Q9WUL7 / ADP-ribosylation factor-like protein 3 / P36405* / ADP ribosylation factor like GTPase 3*ENSMUSG0000002503532
Arl2 / Q9D0J4 / ADP-ribosylation factor-like protein 2 / P36404* / ARL2-SNX15* / ADP ribosylation factor like GTPase 2* / ARL2-SNX15 readthrough (NMD candidate)*ENSMUSG0000002494431
Arl11 / Q6P3A9 / ADP-ribosylation factor-like protein 11 / Q969Q4* / ADP ribosylation factor like GTPase 11*ENSMUSG0000004315731
Arf4 / P61750 / ADP-ribosylation factor 4 / P18085*ENSMUSG0000002187731
Arf5 / P84084 / ADP-ribosylation factor 5 / P84085*ENSMUSG0000002044030
Arl15 / Q8BGR6 / ADP-ribosylation factor-like protein 15 / Q9NXU5* / ADP ribosylation factor like GTPase 15*ENSMUSG0000004234828
Q8BGX0 / Trim23 / E3 ubiquitin-protein ligase TRIM23 / P36406* / tripartite motif containing 23*ENSMUSG0000002171227
Arl14 / ADP ribosylation factor like GTPase 14 / Q8N4G2*ENSMUSG0000009820727


Protein motifs (from Interpro)
Interpro ID Name
 IPR005225  Small GTP-binding protein domain
 IPR006689  Small GTPase superfamily, ARF/SAR type
 IPR024156  Small GTPase superfamily, ARF type
 IPR027417  P-loop containing nucleoside triphosphate hydrolase


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0007049 cell cycle IEA
 biological_processGO:0007059 chromosome segregation ISO
 biological_processGO:0032418 lysosome localization IEA
 biological_processGO:0051301 cell division IEA
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005764 lysosome IEA
 cellular_componentGO:0005765 lysosomal membrane ISO
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005819 spindle IEA
 cellular_componentGO:0005856 cytoskeleton IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0030496 midbody IEA
 cellular_componentGO:0031902 late endosome membrane IEA
 cellular_componentGO:0051233 spindle midzone IEA
 molecular_functionGO:0000166 nucleotide binding IEA
 molecular_functionGO:0005525 GTP binding IEA
 molecular_functionGO:0019003 GDP binding IEA
 molecular_functionGO:0043014 alpha-tubulin binding IEA
 molecular_functionGO:0048487 beta-tubulin binding IEA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001698 reduced embryo size "smaller proportions of embryo compared to littermates" [J:61790]
Show

Allelic Composition: Bag3tm1c(EUCOMM)Hmgu/Bag3tm1.1Chen,Tg(Myhca-cre)1Abel/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * FVB/N

Allelic Composition: Arl8btm1Kkon/Arl8btm1Kkon,Tg(Ttr-cre)1Hadj/0
Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

 MP:0001718 abnormal yolk sac "malformed extraembryonic tissue which contributes to hematopoietic circulation" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, MGI:cls, J:12623]
Show

Allelic Composition: Bag3tm1c(EUCOMM)Hmgu/Bag3tm1.1Chen,Tg(Myhca-cre)1Abel/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * FVB/N

Allelic Composition: Arl8btm1Kkon/Arl8btm1Kkon,Tg(Ttr-cre)1Hadj/0
Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

 MP:0004264 abnormal extraembryonic tissue physiology "functional anomaly of the membranes involved with embryonic protection and nutrition" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Bag3tm1c(EUCOMM)Hmgu/Bag3tm1.1Chen,Tg(Myhca-cre)1Abel/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * FVB/N

Allelic Composition: Arl8btm1Kkon/Arl8btm1Kkon,Tg(Ttr-cre)1Hadj/0
Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

 MP:0004646 decreased cervical vertebrae number "reduced number of the seven bony segments of the spine located anterior to the thoracic vertebrae and caudal to the skull" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/Apptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0004924 abnormal behavior "anomalies in the actions, reactions, or performance of an organism in response to external or internal stimuli compared to controls" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/Apptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0005332 abnormal amino acid level "aberrant concentration of these organic compounds, which, when polymerized, form proteins" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Arl8btm1Kkon/Arl8btm1Kkon,Tg(Ttr-cre)1Hadj/0
Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

 MP:0005565 increased blood urea nitrogen level "high circulating concentration of nitrogen, in the form of urea; commonly used to measure renal function" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/Apptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0008932 abnormal embryonic tissue physiology "any functional anomaly in any of the tissues of the embryo proper" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Arl8btm1Kkon/Arl8btm1Kkon,Tg(Ttr-cre)1Hadj/0
Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

 MP:0011089 complete perinatal lethality "death of all organisms of a given genotype in a population within the perinatal period (Mus: E18.5 through postnatal day 1)" [MGI:csmith]
Show

Allelic Composition: Bag3tm1c(EUCOMM)Hmgu/Bag3tm1.1Chen,Tg(Myhca-cre)1Abel/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * FVB/N

 MP:0011110 partial preweaning lethality "the appearance of lower than Mendelian ratios of organisms of a given genotype due to death of some, but not all of the organisms between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
Show

Allelic Composition: Apptm1b(KOMP)Wtsi/Apptm1b(KOMP)Wtsi
Genetic Background: C57BL/6N-Apptm1b(KOMP)Wtsi/Ics

 MP:0020515 abnormal visceral yolk sac endoderm morphology "any structural anomaly of the portion of the visceral yolk sac consisting of endoderm-derived cells that is responsible for absorption of nutrients" [https://discovery.lifemapsc.com/in-vivo-development/yolk-sac/yolk-sac-endoderm, PMID:20672346]
Show

Allelic Composition: Bag3tm1c(EUCOMM)Hmgu/Bag3tm1.1Chen,Tg(Myhca-cre)1Abel/0
Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * C57BL/6N * FVB/N

Allelic Composition: Arl8btm1Kkon/Arl8btm1Kkon,Tg(Ttr-cre)1Hadj/0
Genetic Background: involves: C57BL/6J * C57BL/6N * CBA/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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