ENSG00000107862


Homo sapiens

Features
Gene ID: ENSG00000107862
  
Biological name :GBF1
  
Synonyms : GBF1 / golgi brefeldin A resistant guanine nucleotide exchange factor 1 / Q92538
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 10
Strand: 1
Band: q24.32
Gene start: 102245532
Gene end: 102382899
  
Corresponding Affymetrix probe sets: 201439_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000359000
NCBI entrez gene - 8729     See in Manteia.
OMIM - 603698
RefSeq - NM_004193
RefSeq - XM_017016864
RefSeq - NM_001199378
RefSeq - NM_001199379
RefSeq - XM_011540314
RefSeq - XM_017016861
RefSeq - XM_017016862
RefSeq - XM_017016863
RefSeq - XM_005270261
RefSeq - XM_006718047
RefSeq - XM_006718048
RefSeq - XM_006718049
RefSeq - XM_006718050
RefSeq - XM_011540312
RefSeq - XM_011540313
RefSeq Peptide - NP_001186308
RefSeq Peptide - NP_004184
RefSeq Peptide - NP_001186307
swissprot - Q92538
Ensembl - ENSG00000107862
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gbf1ENSDARG00000027016Danio rerio
 GBF1ENSGALG00000005637Gallus gallus
 Gbf1ENSMUSG00000025224Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PSD4 / Q8NDX1 / pleckstrin and Sec7 domain containing 4ENSG0000012563710
PSD / A5PKW4 / pleckstrin and Sec7 domain containingENSG000000599159
PSD3 / Q9NYI0 / pleckstrin and Sec7 domain containing 3ENSG000001560119
PSD2 / Q9BQI7 / pleckstrin and Sec7 domain containing 2ENSG000001460058


Protein motifs (from Interpro)
Interpro ID Name
 IPR000904  Sec7 domain
 IPR016024  Armadillo-type fold
 IPR023394  Sec7, C-terminal domain superfamily
 IPR032691  Guanine nucleotide exchange factor, N-terminal
 IPR035999  Sec7 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002263 cell activation involved in immune response IMP
 biological_processGO:0006888 ER to Golgi vesicle-mediated transport TAS
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER TAS
 biological_processGO:0006892 post-Golgi vesicle-mediated transport TAS
 biological_processGO:0006895 Golgi to endosome transport IMP
 biological_processGO:0007030 Golgi organization IMP
 biological_processGO:0007346 regulation of mitotic cell cycle IMP
 biological_processGO:0015031 protein transport IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0030593 neutrophil chemotaxis IMP
 biological_processGO:0032012 regulation of ARF protein signal transduction IEA
 biological_processGO:0034067 protein localization to Golgi apparatus IMP
 biological_processGO:0042147 retrograde transport, endosome to Golgi IMP
 biological_processGO:0048205 COPI coating of Golgi vesicle IMP
 biological_processGO:0061162 establishment of monopolar cell polarity IMP
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070973 protein localization to endoplasmic reticulum exit site IMP
 biological_processGO:0090166 Golgi disassembly IMP
 biological_processGO:0097111 endoplasmic reticulum-Golgi intermediate compartment organization IMP
 biological_processGO:0098586 cellular response to virus IMP
 biological_processGO:1903409 reactive oxygen species biosynthetic process IMP
 biological_processGO:1903420 protein localization to endoplasmic reticulum tubular network IMP
 biological_processGO:2000008 regulation of protein localization to cell surface IMP
 cellular_componentGO:0000139 Golgi membrane TAS
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment IEA
 cellular_componentGO:0005794 Golgi apparatus IEA
 cellular_componentGO:0005795 Golgi stack IEA
 cellular_componentGO:0005801 cis-Golgi network IEA
 cellular_componentGO:0005802 trans-Golgi network IDA
 cellular_componentGO:0005811 lipid droplet IEA
 cellular_componentGO:0005829 cytosol TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0031252 cell leading edge IDA
 molecular_functionGO:0005085 guanyl-nucleotide exchange factor activity TAS
 molecular_functionGO:0005086 ARF guanyl-nucleotide exchange factor activity IBA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA
 molecular_functionGO:0008289 lipid binding IEA
 molecular_functionGO:0080025 phosphatidylinositol-3,5-bisphosphate binding IDA


Pathways (from Reactome)
Pathway description
Clathrin derived vesicle budding
VxPx cargo-targeting to cilium
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129083 COPB1 / P53618 / coatomer protein complex subunit beta 1  / complex / reaction
 ENSG00000122218 COPA / P53621 / coatomer protein complex subunit alpha  / reaction / complex
 ENSG00000111481 COPZ1 / P61923 / coatomer protein complex subunit zeta 1  / complex / reaction
 ENSG00000138768 USO1 / O60763 / USO1 vesicle transport factor  / reaction / complex
 ENSG00000105669 COPE / O14579 / coatomer protein complex subunit epsilon  / complex / reaction
 ENSG00000095139 ARCN1 / P48444 / archain 1  / complex / reaction
 ENSG00000168374 ARF4 / P18085 / ADP ribosylation factor 4  / complex / reaction
 ENSG00000174903 RAB1B / Q9H0U4 / RAB1B, member RAS oncogene family  / complex / reaction
 ENSG00000181789 COPG1 / Q9Y678 / coatomer protein complex subunit gamma 1  / complex / reaction
 ENSG00000158623 COPG2 / Q9UBF2 / coatomer protein complex subunit gamma 2  / complex / reaction
 ENSG00000184432 COPB2 / P35606 / coatomer protein complex subunit beta 2  / reaction / complex
 ENSG00000143761 ARF1 / P84077 / ADP ribosylation factor 1  / reaction
 ENSG00000005243 COPZ2 / Q9P299 / coatomer protein complex subunit zeta 2  / reaction / complex






 

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