ENSMUSG00000025224


Mus musculus

Features
Gene ID: ENSMUSG00000025224
  
Biological name :Gbf1
  
Synonyms : Gbf1 / golgi brefeldin A resistant guanine nucleotide exchange factor 1
  
Possible biological names infered from orthology : Q92538
  
Species: Mus musculus
  
Chr. number: 19
Strand: 1
Band: C3
Gene start: 46152509
Gene end: 46286510
  
Corresponding Affymetrix probe sets: 10463557 (MoGene1.0st)   10338168 (MoGene1.0st)   10338244 (MoGene1.0st)   10338421 (MoGene1.0st)   10339456 (MoGene1.0st)   10339710 (MoGene1.0st)   10339729 (MoGene1.0st)   10339753 (MoGene1.0st)   10339774 (MoGene1.0st)   10339961 (MoGene1.0st)   10340005 (MoGene1.0st)   10340036 (MoGene1.0st)   10340181 (MoGene1.0st)   10340237 (MoGene1.0st)   10340432 (MoGene1.0st)   10340633 (MoGene1.0st)   10340647 (MoGene1.0st)   10340823 (MoGene1.0st)   10340860 (MoGene1.0st)   10340979 (MoGene1.0st)   10341010 (MoGene1.0st)   10341242 (MoGene1.0st)   10342021 (MoGene1.0st)   10342360 (MoGene1.0st)   10342537 (MoGene1.0st)   10342830 (MoGene1.0st)   10342913 (MoGene1.0st)   10342983 (MoGene1.0st)   10343063 (MoGene1.0st)   10343383 (MoGene1.0st)   10343701 (MoGene1.0st)   10338158 (MoGene1.0st)   10338165 (MoGene1.0st)   10338184 (MoGene1.0st)   10338309 (MoGene1.0st)   10338370 (MoGene1.0st)   10338426 (MoGene1.0st)   10338440 (MoGene1.0st)   10338981 (MoGene1.0st)   10339034 (MoGene1.0st)   10339090 (MoGene1.0st)   10339115 (MoGene1.0st)   10339142 (MoGene1.0st)   10339303 (MoGene1.0st)   10339371 (MoGene1.0st)   10339492 (MoGene1.0st)   10339499 (MoGene1.0st)   10339780 (MoGene1.0st)   10339977 (MoGene1.0st)   10340048 (MoGene1.0st)   10340085 (MoGene1.0st)   10340149 (MoGene1.0st)   10340189 (MoGene1.0st)   10340330 (MoGene1.0st)   10340449 (MoGene1.0st)   10340747 (MoGene1.0st)   10340817 (MoGene1.0st)   10341065 (MoGene1.0st)   10341122 (MoGene1.0st)   10341295 (MoGene1.0st)   10341394 (MoGene1.0st)   10341398 (MoGene1.0st)   10341415 (MoGene1.0st)   10341546 (MoGene1.0st)   10341743 (MoGene1.0st)   10342050 (MoGene1.0st)   10342062 (MoGene1.0st)   10342103 (MoGene1.0st)   10342570 (MoGene1.0st)   10342627 (MoGene1.0st)   10342638 (MoGene1.0st)   10342663 (MoGene1.0st)   10342731 (MoGene1.0st)   10342743 (MoGene1.0st)   10342826 (MoGene1.0st)   10342879 (MoGene1.0st)   10342891 (MoGene1.0st)   10342954 (MoGene1.0st)   10343220 (MoGene1.0st)   10343243 (MoGene1.0st)   10343428 (MoGene1.0st)   10343641 (MoGene1.0st)   10343648 (MoGene1.0st)   10343705 (MoGene1.0st)   10343821 (MoGene1.0st)   10343912 (MoGene1.0st)   10343930 (MoGene1.0st)   10344231 (MoGene1.0st)   10344427 (MoGene1.0st)   10344515 (MoGene1.0st)   10344516 (MoGene1.0st)   10344544 (MoGene1.0st)   10344570 (MoGene1.0st)   1415709_s_at (Mouse Genome 430 2.0 Array)   1415757_at (Mouse Genome 430 2.0 Array)   1432676_at (Mouse Genome 430 2.0 Array)   1432677_at (Mouse Genome 430 2.0 Array)   1438207_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000135062
Ensembl peptide - ENSMUSP00000026254
Ensembl peptide - ENSMUSP00000134762
Ensembl peptide - ENSMUSP00000135847
Ensembl peptide - ENSMUSP00000135850
NCBI entrez gene - 107338     See in Manteia.
MGI - MGI:1861607
RefSeq - XM_006526582
RefSeq - NM_178930
RefSeq - XM_006526580
RefSeq - XM_006526581
RefSeq Peptide - NP_849261
swissprot - Q6A099
swissprot - Q6DFZ1
swissprot - H3BLN1
swissprot - H3BLM8
swissprot - H3BIX5
Ensembl - ENSMUSG00000025224
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 gbf1ENSDARG00000027016Danio rerio
 GBF1ENSGALG00000005637Gallus gallus
 GBF1ENSG00000107862Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Psd3 / Q2PFD7 / pleckstrin and Sec7 domain containing 3ENSMUSG000000304659
Psd4 / Q8BLR5 / PH and SEC7 domain-containing protein 4 / Q8NDX1* / pleckstrin and Sec7 domain containing 4*ENSMUSG000000269799
Psd2 / Q6P1I6 / PH and SEC7 domain-containing protein 2 / Q9BQI7* / pleckstrin and Sec7 domain containing 2*ENSMUSG000000243478
Psd / Q5DTT2 / Mus musculus pleckstrin and Sec7 domain containing (Psd), transcript variant 2, mRNA. / A5PKW4* / pleckstrin and Sec7 domain containing*ENSMUSG000000371268


Protein motifs (from Interpro)
Interpro ID Name
 IPR000904  Sec7 domain
 IPR016024  Armadillo-type fold
 IPR023394  Sec7, C-terminal domain superfamily
 IPR032691  Guanine nucleotide exchange factor, N-terminal
 IPR035999  Sec7 domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002263 cell activation involved in immune response ISO
 biological_processGO:0006890 retrograde vesicle-mediated transport, Golgi to ER ISO
 biological_processGO:0006895 Golgi to endosome transport ISO
 biological_processGO:0007030 Golgi organization ISO
 biological_processGO:0007346 regulation of mitotic cell cycle ISO
 biological_processGO:0016192 vesicle-mediated transport IBA
 biological_processGO:0030593 neutrophil chemotaxis ISO
 biological_processGO:0032012 regulation of ARF protein signal transduction IEA
 biological_processGO:0034067 protein localization to Golgi apparatus ISO
 biological_processGO:0042147 retrograde transport, endosome to Golgi ISO
 biological_processGO:0048205 COPI coating of Golgi vesicle ISO
 biological_processGO:0061162 establishment of monopolar cell polarity ISO
 biological_processGO:0065009 regulation of molecular function IEA
 biological_processGO:0070973 protein localization to endoplasmic reticulum exit site ISO
 biological_processGO:0090166 Golgi disassembly ISO
 biological_processGO:0097111 endoplasmic reticulum-Golgi intermediate compartment organization ISO
 biological_processGO:0098586 cellular response to virus ISO
 biological_processGO:1903409 reactive oxygen species biosynthetic process ISO
 biological_processGO:1903420 protein localization to endoplasmic reticulum tubular network ISO
 biological_processGO:2000008 regulation of protein localization to cell surface ISO
 cellular_componentGO:0000139 Golgi membrane IEA
 cellular_componentGO:0005739 mitochondrion IEA
 cellular_componentGO:0005777 peroxisome IEA
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0005793 endoplasmic reticulum-Golgi intermediate compartment ISO
 cellular_componentGO:0005794 Golgi apparatus ISO
 cellular_componentGO:0005795 Golgi stack IEA
 cellular_componentGO:0005801 cis-Golgi network ISO
 cellular_componentGO:0005802 trans-Golgi network ISO
 cellular_componentGO:0005829 cytosol IEA
 cellular_componentGO:0031252 cell leading edge ISO
 molecular_functionGO:0005086 ARF guanyl-nucleotide exchange factor activity IEA
 molecular_functionGO:0005488 binding IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding ISO
 molecular_functionGO:0080025 phosphatidylinositol-3,5-bisphosphate binding ISO


Pathways (from Reactome)
Pathway description
VxPx cargo-targeting to cilium
COPI-mediated anterograde transport
COPI-dependent Golgi-to-ER retrograde traffic


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0004647 decreased lumbar vertebrae number "reduced number of the six bony segments of the spine located anterior to the sacral vertebrae and posterior to the thoracic vertebrae" [MESH:National Library of Medicine_Medical Subject Headings]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0010101 increased sacral vertebrae number "increase of any or all of the four bony segments of the spine located posterior to the lumbar vertebrae and anterior to the caudal vertebrae" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Fgfr1tm1.1(KOMP)Vlcg/Fgfr1+
Genetic Background: C57BL/6N-Fgfr1tm1.1(KOMP)Vlcg/Ucd

 MP:0011100 complete preweaning lethality "death of all organisms of a given genotype in a population between fertilization and weaning age (Mus: approximately 3-4 weeks of age)" [MGI:csmith]
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Allelic Composition: Foxo3tm1.1(KOMP)Vlcg/Foxo3tm1.1(KOMP)Vlcg
Genetic Background: C57BL/6N-Foxo3tm1.1(KOMP)Vlcg/J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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