ENSG00000010610


Homo sapiens

Features
Gene ID: ENSG00000010610
  
Biological name :CD4
  
Synonyms : CD4 / CD4 molecule / P01730
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 12
Strand: 1
Band: p13.31
Gene start: 6786858
Gene end: 6820808
  
Corresponding Affymetrix probe sets: 203547_at (Human Genome U133 Plus 2.0 Array)   216424_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000011653
Ensembl peptide - ENSP00000440720
Ensembl peptide - ENSP00000445167
NCBI entrez gene - 920     See in Manteia.
OMIM - 186940
RefSeq - XM_017020228
RefSeq - NM_000616
RefSeq - NM_001195014
RefSeq - NM_001195015
RefSeq - NM_001195016
RefSeq - NM_001195017
RefSeq Peptide - NP_001181945
RefSeq Peptide - NP_001181946
RefSeq Peptide - NP_001181943
RefSeq Peptide - NP_000607
RefSeq Peptide - NP_001181944
swissprot - P01730
swissprot - F5H480
swissprot - F5GYA9
Ensembl - ENSG00000010610
  
Related genetic diseases (OMIM): 613949 - OKT4 epitope deficiency, 613949
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CD4ENSGALG00000014477Gallus gallus
 Cd4ENSMUSG00000023274Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR000973  T-cell surface antigen CD4
 IPR003598  Immunoglobulin subtype 2
 IPR003599  Immunoglobulin subtype
 IPR007110  Immunoglobulin-like domain
 IPR008424  Immunoglobulin C2-set
 IPR013106  Immunoglobulin V-set domain
 IPR013151  Immunoglobulin
 IPR013783  Immunoglobulin-like fold
 IPR015274  CD4, extracellular
 IPR021963  T cell CD4 receptor C-terminal region
 IPR036179  Immunoglobulin-like domain superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001816 cytokine production IEA
 biological_processGO:0001934 positive regulation of protein phosphorylation IDA
 biological_processGO:0002250 adaptive immune response IEA
 biological_processGO:0002376 immune system process IEA
 biological_processGO:0006948 induction by virus of host cell-cell fusion IDA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IEA
 biological_processGO:0007167 enzyme linked receptor protein signaling pathway TAS
 biological_processGO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway NAS
 biological_processGO:0010524 positive regulation of calcium ion transport into cytosol IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019064 fusion of virus membrane with host plasma membrane TAS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0030217 T cell differentiation IDA
 biological_processGO:0030260 entry into host cell TAS
 biological_processGO:0031295 T cell costimulation TAS
 biological_processGO:0032355 response to estradiol IEA
 biological_processGO:0032507 maintenance of protein location in cell IDA
 biological_processGO:0033280 response to vitamin D IEA
 biological_processGO:0033674 positive regulation of kinase activity IDA
 biological_processGO:0035397 helper T cell enhancement of adaptive immune response IEA
 biological_processGO:0035723 interleukin-15-mediated signaling pathway IDA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042110 T cell activation IEA
 biological_processGO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling IDA
 biological_processGO:0043410 positive regulation of MAPK cascade IDA
 biological_processGO:0045058 T cell selection IDA
 biological_processGO:0045086 positive regulation of interleukin-2 biosynthetic process NAS
 biological_processGO:0045657 positive regulation of monocyte differentiation IDA
 biological_processGO:0045860 positive regulation of protein kinase activity IDA
 biological_processGO:0045893 positive regulation of transcription, DNA-templated IDA
 biological_processGO:0046598 positive regulation of viral entry into host cell IDA
 biological_processGO:0050690 regulation of defense response to virus by virus TAS
 biological_processGO:0050731 positive regulation of peptidyl-tyrosine phosphorylation IEA
 biological_processGO:0050829 defense response to Gram-negative bacterium IEA
 biological_processGO:0050850 positive regulation of calcium-mediated signaling IEA
 biological_processGO:0050852 T cell receptor signaling pathway TAS
 biological_processGO:0050863 regulation of T cell activation IDA
 biological_processGO:0050870 positive regulation of T cell activation IEA
 biological_processGO:0051924 regulation of calcium ion transport IDA
 biological_processGO:0061024 membrane organization TAS
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IDA
 biological_processGO:0097011 cellular response to granulocyte macrophage colony-stimulating factor stimulus IDA
 cellular_componentGO:0005769 early endosome TAS
 cellular_componentGO:0005788 endoplasmic reticulum lumen IEA
 cellular_componentGO:0005789 endoplasmic reticulum membrane IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane IDA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030665 clathrin-coated vesicle membrane TAS
 cellular_componentGO:0042101 T cell receptor complex NAS
 cellular_componentGO:0045121 membrane raft IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0004888 transmembrane signaling receptor activity TAS
 molecular_functionGO:0005201 extracellular matrix structural constituent NAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008270 zinc ion binding IDA
 molecular_functionGO:0015026 coreceptor activity IEA
 molecular_functionGO:0019865 immunoglobulin binding IEA
 molecular_functionGO:0019899 enzyme binding IPI
 molecular_functionGO:0019901 protein kinase binding IEA
 molecular_functionGO:0042011 interleukin-16 binding IPI
 molecular_functionGO:0042012 interleukin-16 receptor activity IDA
 molecular_functionGO:0042289 MHC class II protein binding IPI
 molecular_functionGO:0042802 identical protein binding IPI
 molecular_functionGO:0042803 protein homodimerization activity IDA
 molecular_functionGO:1990782 protein tyrosine kinase binding IPI


Pathways (from Reactome)
Pathway description
Alpha-defensins
Nef Mediated CD4 Down-regulation
Binding and entry of HIV virion
Vpu mediated degradation of CD4
Downstream TCR signaling
Phosphorylation of CD3 and TCR zeta chains
Translocation of ZAP-70 to Immunological synapse
Generation of second messenger molecules
PD-1 signaling
Other interleukin signaling
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0002843 Abnormality of T-cells "An abnormality of B cells, which are lymphocytes whose principle function in the adaptive immune system is to mediate cell-mediated immunity." [HPO:curators]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000183020 AP2A2 / O94973 / adaptor related protein complex 2 alpha 2 subunit  / complex / reaction
 ENSG00000167286 CD3D / P04234 / CD3d molecule  / reaction / complex
 ENSG00000143761 ARF1 / P84077 / ADP ribosylation factor 1  / reaction / complex
 ENSG00000172349 IL16 / Q14005 / interleukin 16  / complex / reaction
 ENSG00000166167 BTRC / Q9Y297 / beta-transducin repeat containing E3 ubiquitin protein ligase  / reaction / complex
 ENSG00000161203 AP2M1 / Q96CW1 / adaptor related protein complex 2 mu 1 subunit  / reaction / complex
 ENSG00000237541 P01906 / HLA-DQA2 / major histocompatibility complex, class II, DQ alpha 2  / complex / reaction
 ENSG00000124181 PLCG1 / P19174 / phospholipase C gamma 1  / reaction
 ENSG00000182866 LCK / P06239 / LCK proto-oncogene, Src family tyrosine kinase  / complex / reaction
 ENSG00000204287 P01903 / HLA-DRA / major histocompatibility complex, class II, DR alpha  / complex / reaction
 ENSG00000047249 Q9UI12 / ATP6V1H / ATPase H+ transporting V1 subunit H  / reaction / complex
 ENSG00000231389 P20036 / HLA-DPA1 / major histocompatibility complex, class II, DP alpha 1  / complex / reaction
 ENSG00000196735 P01909 / HLA-DQA1 / major histocompatibility complex, class II, DQ alpha 1  / complex / reaction
 ENSG00000198821 CD247 / P20963 / CD247 molecule  / reaction / complex
 ENSG00000196961 AP2A1 / O95782 / adaptor related protein complex 2 alpha 1 subunit  / complex / reaction
 ENSG00000211799 TRAV19 / T cell receptor alpha variable 19  / complex / reaction
 ENSG00000042753 AP2S1 / P53680 / adaptor related protein complex 2 sigma 1 subunit  / reaction / complex
 ENSG00000160654 CD3G / P09693 / CD3g molecule  / reaction / complex
 ENSG00000065675 PRKCQ / Q04759 / protein kinase C theta  / reaction
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / reaction
 ENSG00000043462 LCP2 / Q13094 / lymphocyte cytosolic protein 2  / reaction
 ENSG00000113558 SKP1 / P63208 / S-phase kinase associated protein 1  / reaction / complex
 ENSG00000006125 AP2B1 / P63010 / adaptor related protein complex 2 beta 1 subunit  / complex / reaction
 ENSG00000115085 ZAP70 / P43403 / zeta chain of T cell receptor associated protein kinase 70  / reaction / complex
 ENSG00000100351 GRAP2 / O75791 / GRB2-related adaptor protein 2  / reaction
 ENSG00000198851 CD3E / P07766 / CD3e molecule  / complex / reaction
 ENSG00000213658 LAT / O43561 / linker for activation of T cells  / reaction
 ENSG00000103653 CSK / P41240 / C-terminal Src kinase  / reaction
 ENSG00000121966 CXCR4 / P61073 / C-X-C motif chemokine receptor 4  / complex
 ENSG00000160791 CCR5 / P51681 / C-C motif chemokine receptor 5 (gene/pseudogene)  / complex
 ENSG00000239839 DEFA3 / P59666 / defensin alpha 3  / complex / reaction
 ENSG00000111679 PTPN6 / P29350 / protein tyrosine phosphatase, non-receptor type 6  / reaction
 ENSG00000179295 PTPN11 / Q06124 / protein tyrosine phosphatase, non-receptor type 11  / reaction
 ENSG00000134242 PTPN22 / Q9Y2R2 / protein tyrosine phosphatase, non-receptor type 22  / reaction
 ENSG00000206047 DEFA1 / P59665 / defensin alpha 1  / complex / reaction
 ENSG00000149177 PTPRJ / Q12913 / protein tyrosine phosphatase, receptor type J  / reaction






 

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