ENSG00000239839


Homo sapiens

Features
Gene ID: ENSG00000239839
  
Biological name :DEFA3
  
Synonyms : DEFA3 / defensin alpha 3 / P59666
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p23.1
Gene start: 7015869
Gene end: 7018301
  
Corresponding Affymetrix probe sets: 205033_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000328359
NCBI entrez gene - 1668     See in Manteia.
OMIM - 604522
RefSeq - XM_011534741
RefSeq - NM_005217
RefSeq Peptide - NP_005208
swissprot - P59666
swissprot - Q6EZE9
Ensembl - ENSG00000239839
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DEFA1B / P59665 / defensin alpha 1BENSG0000024024799
DEFA1 / P59665 / defensin alpha 1ENSG0000020604799
DEFA6 / Q01524 / defensin alpha 6ENSG0000016482249
DEFA5 / Q01523 / defensin alpha 5ENSG0000016481648
DEFA4 / P12838 / defensin alpha 4ENSG0000016482146


Protein motifs (from Interpro)
Interpro ID Name
 IPR002366  Defensin propeptide
 IPR006080  Beta/alpha defensin
 IPR006081  Alpha-defensin
 IPR016327  Alpha-defensin propeptide


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002227 innate immune response in mucosa IDA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0019731 antibacterial humoral response IDA
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IDA
 biological_processGO:0031640 killing of cells of other organism IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0050830 defense response to Gram-positive bacterium IDA
 biological_processGO:0050832 defense response to fungus IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IDA
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA
 molecular_functionGO:0003674 molecular_function ND
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Defensins
Alpha-defensins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000239839 DEFA3 / P59666 / defensin alpha 3  / complex
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / complex / reaction






 

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