ENSG00000164816


Homo sapiens

Features
Gene ID: ENSG00000164816
  
Biological name :DEFA5
  
Synonyms : DEFA5 / defensin alpha 5 / Q01523
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p23.1
Gene start: 7055304
Gene end: 7056734
  
Corresponding Affymetrix probe sets: 207529_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000329890
NCBI entrez gene - 1670     See in Manteia.
OMIM - 600472
RefSeq - NM_021010
RefSeq Peptide - NP_066290
swissprot - Q01523
Ensembl - ENSG00000164816
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DEFA4 / P12838 / defensin alpha 4ENSG0000016482150
DEFA6 / Q01524 / defensin alpha 6ENSG0000016482249
DEFA3 / P59666 / defensin alpha 3ENSG0000023983948
DEFA1B / P59665 / defensin alpha 1BENSG0000024024748
DEFA1 / P59665 / defensin alpha 1ENSG0000020604748


Protein motifs (from Interpro)
Interpro ID Name
 IPR002366  Defensin propeptide
 IPR006080  Beta/alpha defensin
 IPR006081  Alpha-defensin
 IPR016327  Alpha-defensin propeptide


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006952 defense response IEA
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0031640 killing of cells of other organism IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0045087 innate immune response IMP
 biological_processGO:0050829 defense response to Gram-negative bacterium IMP
 biological_processGO:0050830 defense response to Gram-positive bacterium IMP
 biological_processGO:0050832 defense response to fungus IEA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IC
 biological_processGO:1905710 positive regulation of membrane permeability IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0030133 transport vesicle IEA
 cellular_componentGO:0031410 cytoplasmic vesicle IEA
 cellular_componentGO:0034774 secretory granule lumen TAS
 molecular_functionGO:0042803 protein homodimerization activity IDA


Pathways (from Reactome)
Pathway description
Defensins
Alpha-defensins


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164816 DEFA5 / Q01523 / defensin alpha 5  / complex
 ENSG00000010438 PRSS3 / P35030 / serine protease 3  / reaction
 ENSG00000275896 PRSS2 / P07478 / serine protease 2  / reaction






 

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