ENSG00000010438


Homo sapiens

Features
Gene ID: ENSG00000010438
  
Biological name :PRSS3
  
Synonyms : P35030 / PRSS3 / serine protease 3
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 9
Strand: 1
Band: p13.3
Gene start: 33750466
Gene end: 33799231
  
Corresponding Affymetrix probe sets: 207463_x_at (Human Genome U133 Plus 2.0 Array)   213421_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000340889
Ensembl peptide - ENSP00000368715
Ensembl peptide - ENSP00000401249
Ensembl peptide - ENSP00000401828
Ensembl peptide - ENSP00000354280
NCBI entrez gene - 5646     See in Manteia.
OMIM - 613578
RefSeq - XM_011517965
RefSeq - NM_001197097
RefSeq - NM_001197098
RefSeq - NM_002771
RefSeq - NM_007343
RefSeq Peptide - NP_001184026
RefSeq Peptide - NP_001184027
RefSeq Peptide - NP_002762
RefSeq Peptide - NP_031369
swissprot - P35030
swissprot - B1AN99
Ensembl - ENSG00000010438
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prss1ENSDARG00000042993Danio rerio
 ENSGALG00000040609Gallus gallus
 ENSGALG00000030650Gallus gallus
 ENSGALG00000027291Gallus gallus
 PRSS2ENSGALG00000032796Gallus gallus
 Gm10334ENSMUSG00000071517Mus musculus
 Gm5771ENSMUSG00000058119Mus musculus
 Prss1ENSMUSG00000062751Mus musculus
 Prss2ENSMUSG00000057163Mus musculus
 Prss3ENSMUSG00000071519Mus musculus
 Try10ENSMUSG00000071521Mus musculus
 Try4ENSMUSG00000054106Mus musculus
 Try5ENSMUSG00000036938Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRSS2 / P07478 / serine protease 2ENSG0000027589669
PRSS1 / P07477 / serine protease 1ENSG0000020498368
KLK15 / Q9H2R5 / kallikrein related peptidase 15ENSG0000017456235
KLK11 / Q9UBX7 / kallikrein related peptidase 11ENSG0000016775735
KLK13 / Q9UKR3 / kallikrein related peptidase 13ENSG0000016775934
KLK14 / Q9P0G3 / kallikrein related peptidase 14ENSG0000012943734
AC011473.4ENSG0000026974133
KLK6 / Q92876 / kallikrein related peptidase 6ENSG0000016775533
KLK9 / Q9UKQ9 / kallikrein related peptidase 9ENSG0000021302233
KLK8 / O60259 / kallikrein related peptidase 8ENSG0000012945533


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis TAS
 biological_processGO:0007586 digestion IEA
 biological_processGO:0009235 cobalamin metabolic process TAS
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0031638 zymogen activation IDA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0043542 endothelial cell migration IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0070062 extracellular exosome HDA
 cellular_componentGO:1904724 tertiary granule lumen TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity IDA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity TAS
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Alpha-defensins
Cobalamin (Cbl, vitamin B12) transport and metabolism
Neutrophil degranulation
Antimicrobial peptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164816 DEFA5 / Q01523 / defensin alpha 5  / reaction






 

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