ENSG00000275896


Homo sapiens

Features
Gene ID: ENSG00000275896
  
Biological name :PRSS2
  
Synonyms : P07478 / PRSS2 / serine protease 2
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 7
Strand: 1
Band: q34
Gene start: 142760398
Gene end: 142774564
  
Corresponding Affymetrix probe sets: 205402_x_at (Human Genome U133 Plus 2.0 Array)   215395_x_at (Human Genome U133 Plus 2.0 Array)   216470_x_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000488077
Ensembl peptide - ENSP00000488789
Ensembl peptide - ENSP00000488437
Ensembl peptide - ENSP00000488338
NCBI entrez gene - 5645     See in Manteia.
OMIM - 601564
RefSeq - NM_002770
RefSeq - NM_001303414
RefSeq Peptide - NP_001290343
RefSeq Peptide - NP_002761
swissprot - Q5NV56
swissprot - A6XMV8
swissprot - A0A0J9YYC8
swissprot - P07478
swissprot - A6XMV9
Ensembl - ENSG00000275896
  
Related genetic diseases (OMIM): 167800 - {Pancreatitis, chronic, protection against}, 167800
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 prss1ENSDARG00000042993Danio rerio
 ENSGALG00000040609Gallus gallus
 ENSGALG00000030650Gallus gallus
 ENSGALG00000027291Gallus gallus
 PRSS2ENSGALG00000032796Gallus gallus
 Gm10334ENSMUSG00000071517Mus musculus
 Gm5771ENSMUSG00000058119Mus musculus
 Prss1ENSMUSG00000062751Mus musculus
 Prss2ENSMUSG00000057163Mus musculus
 Prss3ENSMUSG00000071519Mus musculus
 Try10ENSMUSG00000071521Mus musculus
 Try4ENSMUSG00000054106Mus musculus
 Try5ENSMUSG00000036938Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
PRSS1 / P07477 / serine protease 1ENSG0000020498385
PRSS3 / P35030 / serine protease 3ENSG0000001043881
KLK15 / Q9H2R5 / kallikrein related peptidase 15ENSG0000017456242
KLK13 / Q9UKR3 / kallikrein related peptidase 13ENSG0000016775941
KLK11 / Q9UBX7 / kallikrein related peptidase 11ENSG0000016775741
KLK14 / Q9P0G3 / kallikrein related peptidase 14ENSG0000012943739
KLK6 / Q92876 / kallikrein related peptidase 6ENSG0000016775539
KLK8 / O60259 / kallikrein related peptidase 8ENSG0000012945538
KLK9 / Q9UKQ9 / kallikrein related peptidase 9ENSG0000021302237
AC011473.4ENSG0000026974137


Protein motifs (from Interpro)
Interpro ID Name
 IPR001254  Serine proteases, trypsin domain
 IPR001314  Peptidase S1A, chymotrypsin family
 IPR009003  Peptidase S1, PA clan
 IPR018114  Serine proteases, trypsin family, histidine active site
 IPR033116  Serine proteases, trypsin family, serine active site


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006508 proteolysis IEA
 biological_processGO:0007586 digestion IBA
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0022617 extracellular matrix disassembly TAS
 biological_processGO:0030307 positive regulation of cell growth TAS
 biological_processGO:0030574 collagen catabolic process IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045785 positive regulation of cell adhesion TAS
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IMP
 cellular_componentGO:0031012 extracellular matrix TAS
 cellular_componentGO:0035578 azurophil granule lumen TAS
 molecular_functionGO:0004222 metalloendopeptidase activity TAS
 molecular_functionGO:0004252 serine-type endopeptidase activity IEA
 molecular_functionGO:0005509 calcium ion binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008233 peptidase activity IEA
 molecular_functionGO:0008236 serine-type peptidase activity IEA
 molecular_functionGO:0016787 hydrolase activity IEA
 molecular_functionGO:0046872 metal ion binding IEA


Pathways (from Reactome)
Pathway description
Collagen degradation
Alpha-defensins
Activation of Matrix Metalloproteinases
Neutrophil degranulation
Antimicrobial peptides


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 HP:0000819 Diabetes mellitus 
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 HP:0000952 Jaundice "Yellow pigmentation of the skin or sclera due to bilirubin, which in turn is the result of increased bilirubin concentration in the bloodstream." [HPO:curators]
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 HP:0001974 Leukocytosis "An abnormal increase in the number of `leukocytes` (CL:0000738) in the `blood` (FMA:9670)." [HPO:probinson]
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 HP:0002027 Abdominal pain 
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 HP:0005213 Pancreatic calcification 
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 HP:0011227 Elevated C-reactive protein level "An abnormal elevation of the C-reactive protein level in serum." [HPO:probinson]
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 HP:0012379 Abnormal enzyme/coenzyme activity "An altered ability of any enzyme or their cofactors to act as catalysts." [HPO:probinson, MP:0005584]
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 HP:0030247 Splanchnic vein thrombosis "The term splanchnic vein thrombosis encompasses Budd-Chiari syndrome (hepatic vein thrombosis), extrahepatic portal vein obstruction (EHPVO), and mesenteric vein thrombosis; the word splanchnic is used to refer to the visceral organs (of the abdominal cavity)." [HPO:probinson, pmid:20532730]
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 HP:0100027 Recurrent pancreatitis "A `recurrent` (PATO:0000427) form of `pancreatitis` (HP:0001733)." [HPO:probinson]
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Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000164816 DEFA5 / Q01523 / defensin alpha 5  / reaction
 ENSG00000100985 MMP9 / P14780 / matrix metallopeptidase 9  / reaction






 

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