ENSG00000206047


Homo sapiens

Features
Gene ID: ENSG00000206047
  
Biological name :DEFA1
  
Synonyms : DEFA1 / defensin alpha 1 / P59665
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 8
Strand: -1
Band: p23.1
Gene start: 6977649
Gene end: 6980080
  
Corresponding Affymetrix probe sets: 205033_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000372126
Ensembl peptide - ENSP00000372139
NCBI entrez gene - 1667     See in Manteia.
OMIM - 125220
RefSeq - XM_011534740
RefSeq - NM_004084
RefSeq Peptide - NP_004075
swissprot - P59665
Ensembl - ENSG00000206047
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
DEFA1B / P59665 / defensin alpha 1BENSG00000240247100
DEFA3 / P59666 / defensin alpha 3ENSG0000023983999
DEFA6 / Q01524 / defensin alpha 6ENSG0000016482249
DEFA5 / Q01523 / defensin alpha 5ENSG0000016481648
DEFA4 / P12838 / defensin alpha 4ENSG0000016482146


Protein motifs (from Interpro)
Interpro ID Name
 IPR002366  Defensin propeptide
 IPR006080  Beta/alpha defensin
 IPR006081  Alpha-defensin
 IPR016327  Alpha-defensin propeptide


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002227 innate immune response in mucosa IDA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006955 immune response TAS
 biological_processGO:0010818 T cell chemotaxis IDA
 biological_processGO:0019730 antimicrobial humoral response TAS
 biological_processGO:0019731 antibacterial humoral response IDA
 biological_processGO:0030520 intracellular estrogen receptor signaling pathway IDA
 biological_processGO:0031640 killing of cells of other organism IEA
 biological_processGO:0042742 defense response to bacterium IEA
 biological_processGO:0042832 defense response to protozoan IMP
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0044657 pore formation in membrane of other organism during symbiotic interaction IDA
 biological_processGO:0050830 defense response to Gram-positive bacterium IDA
 biological_processGO:0050832 defense response to fungus IEA
 biological_processGO:0051607 defense response to virus IEA
 biological_processGO:0051852 disruption by host of symbiont cells IDA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IMP
 cellular_componentGO:0005576 extracellular region TAS
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005796 Golgi lumen TAS
 cellular_componentGO:0031012 extracellular matrix IDA
 cellular_componentGO:0035578 azurophil granule lumen TAS
 cellular_componentGO:0070062 extracellular exosome HDA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000129744 ART1 / P52961 / ADP-ribosyltransferase 1  / reaction
 ENSG00000206047 DEFA1 / P59665 / defensin alpha 1  / complex
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / complex / reaction






 

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