ENSG00000160791


Homo sapiens

Features
Gene ID: ENSG00000160791
  
Biological name :CCR5
  
Synonyms : C-C motif chemokine receptor 5 (gene/pseudogene) / CCR5 / P51681
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p21.31
Gene start: 46370854
Gene end: 46376206
  
Corresponding Affymetrix probe sets: 206991_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000292303
Ensembl peptide - ENSP00000404881
NCBI entrez gene - 1234     See in Manteia.
OMIM - 601373
RefSeq - NM_001100168
RefSeq - NM_000579
RefSeq Peptide - NP_000570
RefSeq Peptide - NP_001093638
swissprot - P51681
swissprot - Q38L21
Ensembl - ENSG00000160791
  
Related genetic diseases (OMIM): 601373 - {HIV infection, susceptibility/resistance to}
  609532 - {Hepatitis C virus, resistance to}, 609532
  610379 - {West nile virus, susceptibility to}, 610379
  612522 - {Diabetes mellitus, insulin-dependent, 22}, 612522
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccr11.1ENSDARG00000070755Danio rerio
 ccr2ENSDARG00000105363Danio rerio
 ccr2ENSDARG00000079829Danio rerio
 CCR2ENSGALG00000011733Gallus gallus
 CCR5ENSGALG00000037077Gallus gallus
 Ccr5ENSMUSG00000079227Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCR2 / P41597 / C-C motif chemokine receptor 2ENSG0000012180767
CCR1 / P32246 / C-C motif chemokine receptor 1ENSG0000016382355
CCR3 / P51677 / C-C motif chemokine receptor 3ENSG0000018362550
CCR4 / P51679 / C-C motif chemokine receptor 4ENSG0000018381347
CCR8 / P51685 / C-C motif chemokine receptor 8ENSG0000017993441
CX3CR1 / P49238 / C-X3-C motif chemokine receptor 1ENSG0000016832939
CCR9 / P51686 / C-C motif chemokine receptor 9ENSG0000017358535
ACKR2 / O00590 / atypical chemokine receptor 2ENSG0000014464834
CCR7 / P32248 / C-C motif chemokine receptor 7ENSG0000012635334
CXCR3 / P49682 / C-X-C motif chemokine receptor 3ENSG0000018681031
CXCR2 / P25025 / C-X-C motif chemokine receptor 2ENSG0000018087131
CCR6 / P51684 / C-C motif chemokine receptor 6ENSG0000011248631
CXCR6 / O00574 / C-X-C motif chemokine receptor 6ENSG0000017221530
CXCR1 / P25024 / C-X-C motif chemokine receptor 1ENSG0000016346430
XCR1 / P46094 / X-C motif chemokine receptor 1ENSG0000017357829
ACKR4 / Q9NPB9 / atypical chemokine receptor 4ENSG0000012904829
CCR10 / P46092 / C-C motif chemokine receptor 10ENSG0000018445129
CXCR4 / P61073 / C-X-C motif chemokine receptor 4ENSG0000012196629
CXCR5 / P32302 / C-X-C motif chemokine receptor 5ENSG0000016068326


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR002240  CC chemokine receptor 5
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEP
 biological_processGO:0002407 dendritic cell chemotaxis TAS
 biological_processGO:0006816 calcium ion transport IDA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response TAS
 biological_processGO:0006968 cellular defense response TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration TAS
 biological_processGO:0007267 cell-cell signaling IDA
 biological_processGO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IDA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0019064 fusion of virus membrane with host plasma membrane TAS
 biological_processGO:0019221 cytokine-mediated signaling pathway TAS
 biological_processGO:0019722 calcium-mediated signaling IDA
 biological_processGO:0023052 signaling IEP
 biological_processGO:0030260 entry into host cell TAS
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:0070723 response to cholesterol IMP
 biological_processGO:0071222 cellular response to lipopolysaccharide IEP
 biological_processGO:2000110 negative regulation of macrophage apoptotic process IEA
 cellular_componentGO:0005737 cytoplasm TAS
 cellular_componentGO:0005768 endosome IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0001618 virus receptor activity IEA
 molecular_functionGO:0003779 actin binding IDA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity TAS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0015026 coreceptor activity TAS
 molecular_functionGO:0016493 C-C chemokine receptor activity IDA
 molecular_functionGO:0019957 C-C chemokine binding IPI
 molecular_functionGO:0071791 chemokine (C-C motif) ligand 5 binding IPI


Pathways (from Reactome)
Pathway description
Binding and entry of HIV virion
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000275302 CCL4 / P13236 / C-C motif chemokine ligand 4  / complex
 ENSG00000010610 CD4 / P01730 / CD4 molecule  / complex
 ENSG00000271503 CCL5 / P13501 / C-C motif chemokine ligand 5  / reaction / complex






 

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