ENSG00000180871


Homo sapiens

Features
Gene ID: ENSG00000180871
  
Biological name :CXCR2
  
Synonyms : C-X-C motif chemokine receptor 2 / CXCR2 / P25025
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 2
Strand: 1
Band: q35
Gene start: 218125289
Gene end: 218137253
  
Corresponding Affymetrix probe sets: 207008_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000392348
Ensembl peptide - ENSP00000392698
Ensembl peptide - ENSP00000416815
Ensembl peptide - ENSP00000415148
Ensembl peptide - ENSP00000413686
Ensembl peptide - ENSP00000410506
Ensembl peptide - ENSP00000319635
NCBI entrez gene - 3579     See in Manteia.
OMIM - 146928
RefSeq - XM_017003992
RefSeq - XM_005246530
RefSeq - XM_017003991
RefSeq - XM_017003990
RefSeq - NM_001168298
RefSeq - NM_001557
RefSeq Peptide - NP_001548
RefSeq Peptide - NP_001161770
swissprot - P25025
swissprot - Q53PC4
swissprot - Q6LCZ7
swissprot - C9JW47
swissprot - C9J1J7
swissprot - C9J2F9
swissprot - C9JG19
Ensembl - ENSG00000180871
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxcr2ENSDARG00000054975Danio rerio
 CXCR1ENSGALG00000036627Gallus gallus
 Cxcr2ENSMUSG00000026180Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CXCR1 / P25024 / C-X-C motif chemokine receptor 1ENSG0000016346475
CXCR3 / P49682 / C-X-C motif chemokine receptor 3ENSG0000018681037
CXCR5 / P32302 / C-X-C motif chemokine receptor 5ENSG0000016068336
CCR4 / P51679 / C-C motif chemokine receptor 4ENSG0000018381335
CCR6 / P51684 / C-C motif chemokine receptor 6ENSG0000011248635
CCR7 / P32248 / C-C motif chemokine receptor 7ENSG0000012635334
CXCR4 / P61073 / C-X-C motif chemokine receptor 4ENSG0000012196633
CCR9 / P51686 / C-C motif chemokine receptor 9ENSG0000017358533
CCR8 / P51685 / C-C motif chemokine receptor 8ENSG0000017993432
CCR10 / P46092 / C-C motif chemokine receptor 10ENSG0000018445132
ACKR2 / O00590 / atypical chemokine receptor 2ENSG0000014464832
ACKR4 / Q9NPB9 / atypical chemokine receptor 4ENSG0000012904831
CCR2 / P41597 / C-C motif chemokine receptor 2ENSG0000012180730
CX3CR1 / P49238 / C-X3-C motif chemokine receptor 1ENSG0000016832930
CCR1 / P32246 / C-C motif chemokine receptor 1ENSG0000016382330
CCR5 / P51681 / C-C motif chemokine receptor 5 (gene/pseudogene)ENSG0000016079130
XCR1 / P46094 / X-C motif chemokine receptor 1ENSG0000017357829
CCR3 / P51677 / C-C motif chemokine receptor 3ENSG0000018362529
CXCR6 / O00574 / C-X-C motif chemokine receptor 6ENSG0000017221528


Protein motifs (from Interpro)
Interpro ID Name
 IPR000057  CXC chemokine receptor 2
 IPR000174  CXC chemokine receptor 1/2
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002407 dendritic cell chemotaxis TAS
 biological_processGO:0002438 acute inflammatory response to antigenic stimulus IEA
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006968 cellular defense response IDA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007166 cell surface receptor signaling pathway IDA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007200 phospholipase C-activating G-protein coupled receptor signaling pathway IDA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0008284 positive regulation of cell proliferation IDA
 biological_processGO:0010666 positive regulation of cardiac muscle cell apoptotic process IEA
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0030901 midbrain development IEA
 biological_processGO:0031623 receptor internalization IDA
 biological_processGO:0033030 negative regulation of neutrophil apoptotic process IEA
 biological_processGO:0038112 interleukin-8-mediated signaling pathway IEA
 biological_processGO:0042119 neutrophil activation IDA
 biological_processGO:0043066 negative regulation of apoptotic process IEA
 biological_processGO:0043117 positive regulation of vascular permeability IEA
 biological_processGO:0043312 neutrophil degranulation TAS
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:0072173 metanephric tubule morphogenesis IEA
 biological_processGO:0090023 positive regulation of neutrophil chemotaxis IEA
 cellular_componentGO:0005622 intracellular IDA
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030667 secretory granule membrane TAS
 cellular_componentGO:0042629 mast cell granule IDA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004918 interleukin-8 receptor activity IDA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016494 C-X-C chemokine receptor activity IEA
 molecular_functionGO:0019959 interleukin-8 binding IEA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events
Neutrophil degranulation


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr