ENSG00000168329


Homo sapiens

Features
Gene ID: ENSG00000168329
  
Biological name :CX3CR1
  
Synonyms : C-X3-C motif chemokine receptor 1 / CX3CR1 / P49238
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: -1
Band: p22.2
Gene start: 39263494
Gene end: 39281735
  
Corresponding Affymetrix probe sets: 1568934_at (Human Genome U133 Plus 2.0 Array)   205898_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000394960
Ensembl peptide - ENSP00000444928
Ensembl peptide - ENSP00000439140
Ensembl peptide - ENSP00000408835
Ensembl peptide - ENSP00000351059
Ensembl peptide - ENSP00000382166
NCBI entrez gene - 1524     See in Manteia.
OMIM - 601470
RefSeq - NM_001171174
RefSeq - NM_001337
RefSeq - NM_001171171
RefSeq - NM_001171172
RefSeq Peptide - NP_001164643
RefSeq Peptide - NP_001328
RefSeq Peptide - NP_001164642
RefSeq Peptide - NP_001164645
swissprot - P49238
swissprot - C9JLM2
swissprot - C9JN40
Ensembl - ENSG00000168329
  
Related genetic diseases (OMIM): 607339 - {Coronary artery disease, resistance to}, 607339
  609423 - {Rapid progression to AIDS from HIV1 infection}, 609423
  613784 - {Macular degeneration, age-related, 12}, 613784
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CX3CR1ENSGALG00000038000Gallus gallus
 Cx3cr1ENSMUSG00000052336Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCR4 / P51679 / C-C motif chemokine receptor 4ENSG0000018381337
CCR2 / P41597 / C-C motif chemokine receptor 2ENSG0000012180737
CCR1 / P32246 / C-C motif chemokine receptor 1ENSG0000016382337
CCR3 / P51677 / C-C motif chemokine receptor 3ENSG0000018362536
CCR8 / P51685 / C-C motif chemokine receptor 8ENSG0000017993435
CCR5 / P51681 / C-C motif chemokine receptor 5 (gene/pseudogene)ENSG0000016079135
ACKR2 / O00590 / atypical chemokine receptor 2ENSG0000014464831
CCR6 / P51684 / C-C motif chemokine receptor 6ENSG0000011248630
CCR7 / P32248 / C-C motif chemokine receptor 7ENSG0000012635330
CXCR3 / P49682 / C-X-C motif chemokine receptor 3ENSG0000018681029
XCR1 / P46094 / X-C motif chemokine receptor 1ENSG0000017357829
ACKR4 / Q9NPB9 / atypical chemokine receptor 4ENSG0000012904828
CXCR2 / P25025 / C-X-C motif chemokine receptor 2ENSG0000018087128
CXCR6 / O00574 / C-X-C motif chemokine receptor 6ENSG0000017221527
CCR9 / P51686 / C-C motif chemokine receptor 9ENSG0000017358527
CXCR4 / P61073 / C-X-C motif chemokine receptor 4ENSG0000012196627
CCR10 / P46092 / C-C motif chemokine receptor 10ENSG0000018445126
CXCR1 / P25024 / C-X-C motif chemokine receptor 1ENSG0000016346426
CXCR5 / P32302 / C-X-C motif chemokine receptor 5ENSG0000016068325


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR005387  CX3C chemokine receptor 1
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002052 positive regulation of neuroblast proliferation IEA
 biological_processGO:0002282 microglial cell activation involved in immune response IEA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006968 cellular defense response TAS
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007613 memory IEA
 biological_processGO:0009611 response to wounding TAS
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0021795 cerebral cortex cell migration IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048246 macrophage chemotaxis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071560 cellular response to transforming growth factor beta stimulus IEA
 biological_processGO:1900272 negative regulation of long-term synaptic potentiation IEA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005634 nucleus IDA
 cellular_componentGO:0005654 nucleoplasm IDA
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0032809 neuronal cell body membrane IEA
 cellular_componentGO:0043005 neuron projection IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004896 cytokine receptor activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016495 C-X3-C chemokine receptor activity IEA
 molecular_functionGO:0019960 C-X3-C chemokine binding IDA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000006210 CX3CL1 / P78423 / C-X3-C motif chemokine ligand 1  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr