ENSG00000006210


Homo sapiens

Features
Gene ID: ENSG00000006210
  
Biological name :CX3CL1
  
Synonyms : CX3CL1 / C-X3-C motif chemokine ligand 1 / P78423
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 16
Strand: 1
Band: q21
Gene start: 57372458
Gene end: 57385048
  
Corresponding Affymetrix probe sets: 203687_at (Human Genome U133 Plus 2.0 Array)   823_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000456830
Ensembl peptide - ENSP00000457996
Ensembl peptide - ENSP00000464114
Ensembl peptide - ENSP00000006053
NCBI entrez gene - 6376     See in Manteia.
OMIM - 601880
RefSeq - NM_001304392
RefSeq - NM_002996
RefSeq Peptide - NP_001291321
RefSeq Peptide - NP_002987
swissprot - P78423
swissprot - A0N0N7
swissprot - H3BSR6
swissprot - H3BV86
swissprot - J3QRA1
Ensembl - ENSG00000006210
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Cx3cl1ENSMUSG00000031778Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001811  Chemokine interleukin-8-like domain
 IPR008097  Fractalkine
 IPR034127  CX3C chemokine domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002523 leukocyte migration involved in inflammatory response IMP
 biological_processGO:0002548 monocyte chemotaxis IBA
 biological_processGO:0006935 chemotaxis IMP
 biological_processGO:0006952 defense response TAS
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010976 positive regulation of neuron projection development ISS
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0030336 negative regulation of cell migration IDA
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0030595 leukocyte chemotaxis TAS
 biological_processGO:0032914 positive regulation of transforming growth factor beta1 production IEA
 biological_processGO:0033622 integrin activation IMP
 biological_processGO:0042060 wound healing IEA
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0048246 macrophage chemotaxis IEA
 biological_processGO:0048247 lymphocyte chemotaxis IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEP
 biological_processGO:0050902 leukocyte adhesive activation IEA
 biological_processGO:0051041 positive regulation of calcium-independent cell-cell adhesion IDA
 biological_processGO:0060055 angiogenesis involved in wound healing IEA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071346 cellular response to interferon-gamma IBA
 biological_processGO:0071347 cellular response to interleukin-1 IBA
 biological_processGO:0071356 cellular response to tumor necrosis factor IBA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005178 integrin binding IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008009 chemokine activity IEA
 molecular_functionGO:0031737 CX3C chemokine receptor binding IDA
 molecular_functionGO:0048020 CCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000168329 CX3CR1 / P49238 / C-X3-C motif chemokine receptor 1  / reaction / complex






 

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