ENSMUSG00000031778


Mus musculus

Features
Gene ID: ENSMUSG00000031778
  
Biological name :Cx3cl1
  
Synonyms : chemokine (C-X3-C motif) ligand 1 / Cx3cl1 / O35188
  
Possible biological names infered from orthology : C-X3-C motif chemokine ligand 1 / P78423
  
Species: Mus musculus
  
Chr. number: 8
Strand: 1
Band: C5
Gene start: 94772009
Gene end: 94782427
  
Corresponding Affymetrix probe sets: 10574220 (MoGene1.0st)   1415803_at (Mouse Genome 430 2.0 Array)   1415804_at (Mouse Genome 430 2.0 Array)   1421610_at (Mouse Genome 430 2.0 Array)   1441884_x_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000034230
Ensembl peptide - ENSMUSP00000148819
Ensembl peptide - ENSMUSP00000148534
Ensembl peptide - ENSMUSP00000123538
Ensembl peptide - ENSMUSP00000117632
NCBI entrez gene - 20312     See in Manteia.
MGI - MGI:1097153
RefSeq - NM_009142
RefSeq Peptide - NP_033168
swissprot - A0A1D5RLW9
swissprot - E0CXC3
swissprot - O35188
swissprot - D6RCV0
swissprot - A0A1D5RMK8
Ensembl - ENSMUSG00000031778
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CX3CL1ENSG00000006210Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001811  Chemokine interleukin-8-like domain
 IPR008097  Fractalkine
 IPR034127  CX3C chemokine domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002523 leukocyte migration involved in inflammatory response IEA
 biological_processGO:0002548 monocyte chemotaxis IBA
 biological_processGO:0006935 chemotaxis ISO
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007155 cell adhesion IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0030336 negative regulation of cell migration IEA
 biological_processGO:0030593 neutrophil chemotaxis IDA
 biological_processGO:0032914 positive regulation of transforming growth factor beta1 production IMP
 biological_processGO:0033622 integrin activation IEA
 biological_processGO:0042060 wound healing IMP
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0048246 macrophage chemotaxis IMP
 biological_processGO:0048247 lymphocyte chemotaxis IDA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050902 leukocyte adhesive activation IEA
 biological_processGO:0051041 positive regulation of calcium-independent cell-cell adhesion IEA
 biological_processGO:0060055 angiogenesis involved in wound healing IMP
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071346 cellular response to interferon-gamma IBA
 biological_processGO:0071347 cellular response to interleukin-1 IBA
 biological_processGO:0071356 cellular response to tumor necrosis factor IBA
 biological_processGO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005178 integrin binding IEA
 molecular_functionGO:0008009 chemokine activity IEA
 molecular_functionGO:0031737 CX3C chemokine receptor binding IEA
 molecular_functionGO:0048020 CCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000183 decreased circulating LDL cholesterol level "less than average concentration in the blood of low density lipoprotein, which normally transports cholesterol to tissues other than the liver" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cx3cl1tm1Sgs/Cx3cl1tm1Sgs
Genetic Background: B6.129-Apoetm1Unc Cx3cl1tm1Sgs

Allelic Composition: Cx3cl1tm1Sgs/Cx3cl1tm1Sgs,Ldlrtm1Her/Ldlr+
Genetic Background: involves: B6.129S4-Cx3cl1tm1Sgs * B6.129S7-Ldlrtm1Her/J

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr2tm1Ifc/Ccr2+,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Cx3cl1tm1Lira/Cx3cl1tm1Lira
Genetic Background: involves: C57BL/6

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cx3cl1tm1Sgs/Cx3cl1tm1Sgs
Genetic Background: B6.129-Apoetm1Unc Cx3cl1tm1Sgs

Allelic Composition: Cx3cl1tm1Sgs/Cx3cl1tm1Sgs,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: B6.129S4-Cx3cl1tm1Sgs * B6.129S7-Ldlrtm1Her/J

 MP:0004778 increased foam cell number "greater than normal number of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cx3cl1tm1Sgs/Cx3cl1tm1Sgs
Genetic Background: B6.129-Apoetm1Unc Cx3cl1tm1Sgs

 MP:0005179 decreased total circulating cholesterol level "less than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Cx3cl1tm1Sgs/Cx3cl1tm1Sgs
Genetic Background: B6.129-Apoetm1Unc Cx3cl1tm1Sgs

Allelic Composition: Cx3cl1tm1Sgs/Cx3cl1tm1Sgs,Ldlrtm1Her/Ldlr+
Genetic Background: involves: B6.129S4-Cx3cl1tm1Sgs * B6.129S7-Ldlrtm1Her/J

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

Allelic Composition: Cx3cl1tm1Sgs/Cx3cl1tm1Sgs,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: B6.129S4-Cx3cl1tm1Sgs * B6.129S7-Ldlrtm1Her/J

Allelic Composition: Cx3cl1tm1Sgs/Cx3cl1tm1Sgs,Ldlrtm1Her/Ldlr+
Genetic Background: involves: B6.129S4-Cx3cl1tm1Sgs * B6.129S7-Ldlrtm1Her/J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr2tm1Ifc/Ccr2tm1Ifc,Cx3cl1tm1Lira/Cx3cl1tm1Lira
Genetic Background: B6.Cg-Apoetm1Unc Cx3cl1tm1Lira Ccr2tm1Ifc

 MP:0006058 decreased cerebral infarction size "decreased size of necrotic area of the cerebrum resulting from a sudden insufficiency of arterial or venous blood supply " [RGD:Rat Genome Database submission, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Lmnatm1Gbon/Lmnatm1Gbon
Genetic Background: involves: 129S2/SvPas * C57BL/6

 MP:0011451 increased susceptibility to dopaminergic neuron neurotoxicity "greater than normal amount of dopaminergic neuronal cell death following exposure to a neurotoxic compound, such as MPTP-induced cell death occurring through interference in mitochondrial metabolism" [MGI:csmith]
Show

Allelic Composition: Cx3cr1tm1Litt/Cx3cr1+
Genetic Background: B6.129P2-Cx3cr1tm1Litt

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000052336 Cx3cr1 / Q9Z0D9 / CX3C chemokine receptor 1 / P49238* / C-X3-C motif chemokine receptor 1*  / reaction / complex






 

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