ENSG00000121807


Homo sapiens

Features
Gene ID: ENSG00000121807
  
Biological name :CCR2
  
Synonyms : C-C motif chemokine receptor 2 / CCR2 / P41597
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 3
Strand: 1
Band: p21.31
Gene start: 46353734
Gene end: 46360928
  
Corresponding Affymetrix probe sets: 206978_at (Human Genome U133 Plus 2.0 Array)   207794_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000383681
Ensembl peptide - ENSP00000399285
Ensembl peptide - ENSP00000396736
Ensembl peptide - ENSP00000292301
NCBI entrez gene - 729230     See in Manteia.
OMIM - 601267
RefSeq - NM_001123396
RefSeq - XM_011534069
RefSeq - NM_001123041
RefSeq Peptide - NP_001116513
RefSeq Peptide - NP_001116868
swissprot - A0A024R2Q0
swissprot - P41597
swissprot - E9PH76
Ensembl - ENSG00000121807
  
Related genetic diseases (OMIM): 601267 - {HIV infection, susceptibility/resistance to}
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccr11.1ENSDARG00000070755Danio rerio
 ccr2ENSDARG00000105363Danio rerio
 ccr2ENSDARG00000079829Danio rerio
 CCR2ENSGALG00000011733Gallus gallus
 CCR5ENSGALG00000037077Gallus gallus
 Ccr2ENSMUSG00000049103Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCR5 / P51681 / C-C motif chemokine receptor 5 (gene/pseudogene)ENSG0000016079163
CCR1 / P32246 / C-C motif chemokine receptor 1ENSG0000016382349
CCR3 / P51677 / C-C motif chemokine receptor 3ENSG0000018362545
CCR4 / P51679 / C-C motif chemokine receptor 4ENSG0000018381343
CX3CR1 / P49238 / C-X3-C motif chemokine receptor 1ENSG0000016832938
CCR8 / P51685 / C-C motif chemokine receptor 8ENSG0000017993436
CCR7 / P32248 / C-C motif chemokine receptor 7ENSG0000012635334
ACKR2 / O00590 / atypical chemokine receptor 2ENSG0000014464832
CCR9 / P51686 / C-C motif chemokine receptor 9ENSG0000017358531
CXCR3 / P49682 / C-X-C motif chemokine receptor 3ENSG0000018681030
XCR1 / P46094 / X-C motif chemokine receptor 1ENSG0000017357829
CXCR2 / P25025 / C-X-C motif chemokine receptor 2ENSG0000018087129
CCR6 / P51684 / C-C motif chemokine receptor 6ENSG0000011248629
ACKR4 / Q9NPB9 / atypical chemokine receptor 4ENSG0000012904828
CXCR1 / P25024 / C-X-C motif chemokine receptor 1ENSG0000016346428
CXCR6 / O00574 / C-X-C motif chemokine receptor 6ENSG0000017221527
CXCR4 / P61073 / C-X-C motif chemokine receptor 4ENSG0000012196627
CCR10 / P46092 / C-C motif chemokine receptor 10ENSG0000018445125
CXCR5 / P32302 / C-X-C motif chemokine receptor 5ENSG0000016068325


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR002237  CC chemokine receptor 2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001974 blood vessel remodeling ISS
 biological_processGO:0002407 dendritic cell chemotaxis TAS
 biological_processGO:0002548 monocyte chemotaxis IEA
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response IEA
 biological_processGO:0002829 negative regulation of type 2 immune response IEA
 biological_processGO:0006874 cellular calcium ion homeostasis ISS
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response TAS
 biological_processGO:0006959 humoral immune response IEA
 biological_processGO:0006968 cellular defense response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007194 negative regulation of adenylate cyclase activity TAS
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration TAS
 biological_processGO:0007259 JAK-STAT cascade TAS
 biological_processGO:0009611 response to wounding TAS
 biological_processGO:0010574 regulation of vascular endothelial growth factor production IEA
 biological_processGO:0010820 positive regulation of T cell chemotaxis IEA
 biological_processGO:0016032 viral process IEA
 biological_processGO:0016525 negative regulation of angiogenesis IEA
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0019233 sensory perception of pain IEA
 biological_processGO:0019725 cellular homeostasis IEA
 biological_processGO:0030097 hemopoiesis IEA
 biological_processGO:0030334 regulation of cell migration IEA
 biological_processGO:0032729 positive regulation of interferon-gamma production IEA
 biological_processGO:0032743 positive regulation of interleukin-2 production IEA
 biological_processGO:0035705 T-helper 17 cell chemotaxis IEA
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process IEA
 biological_processGO:0043310 negative regulation of eosinophil degranulation IEA
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation IEA
 biological_processGO:0048873 homeostasis of number of cells within a tissue IEA
 biological_processGO:0050729 positive regulation of inflammatory response IEA
 biological_processGO:0050870 positive regulation of T cell activation IEA
 biological_processGO:0061756 leukocyte adhesion to vascular endothelial cell IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway ISS
 biological_processGO:0090026 positive regulation of monocyte chemotaxis ISS
 biological_processGO:0090265 positive regulation of immune complex clearance by monocytes and macrophages IEA
 biological_processGO:0097350 neutrophil clearance IEA
 biological_processGO:1903238 positive regulation of leukocyte tethering or rolling IEA
 biological_processGO:2000439 positive regulation of monocyte extravasation IEA
 biological_processGO:2000451 positive regulation of CD8-positive, alpha-beta T cell extravasation IEA
 biological_processGO:2000464 positive regulation of astrocyte chemotaxis IDA
 biological_processGO:2000473 positive regulation of hematopoietic stem cell migration IEA
 cellular_componentGO:0005737 cytoplasm IDA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane TAS
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane TAS
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0043204 perikaryon ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity TAS
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016493 C-C chemokine receptor activity IEA
 molecular_functionGO:0019955 cytokine binding IEA
 molecular_functionGO:0031727 CCR2 chemokine receptor binding IDA
 molecular_functionGO:0035715 chemokine (C-C motif) ligand 2 binding IEA
 molecular_functionGO:0035716 chemokine (C-C motif) ligand 12 binding IEA
 molecular_functionGO:0035717 chemokine (C-C motif) ligand 7 binding IEA
 molecular_functionGO:0042803 protein homodimerization activity ISS


Pathways (from Reactome)
Pathway description
Beta defensins
Chemokine receptors bind chemokines
G alpha (i) signalling events
Interleukin-10 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000181374 CCL13 / Q99616 / C-C motif chemokine ligand 13  / reaction / complex
 ENSG00000275152 CCL16 / O15467 / C-C motif chemokine ligand 16  / reaction / complex
 ENSG00000177243 P81534 / DEFB103B / defensin beta 103B  / reaction / complex
 ENSG00000177257 DEFB4B / O15263 / defensin beta 4B  / reaction / complex






 

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