ENSG00000181374


Homo sapiens

Features
Gene ID: ENSG00000181374
  
Biological name :CCL13
  
Synonyms : CCL13 / C-C motif chemokine ligand 13 / Q99616
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q12
Gene start: 34356452
Gene end: 34358610
  
Corresponding Affymetrix probe sets: 206407_s_at (Human Genome U133 Plus 2.0 Array)   216714_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000225844
Ensembl peptide - ENSP00000463667
NCBI entrez gene - 6357     See in Manteia.
OMIM - 601391
RefSeq - NM_005408
RefSeq Peptide - NP_005399
swissprot - Q99616
swissprot - J3QLQ9
Ensembl - ENSG00000181374
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
No match


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCL2 / P13500 / C-C motif chemokine ligand 2ENSG0000010869164
CCL11 / P51671 / C-C motif chemokine ligand 11ENSG0000017215663
CCL7 / P80098 / C-C motif chemokine ligand 7ENSG0000010868862
CCL8 / P80075 / C-C motif chemokine ligand 8ENSG0000010870061
CCL24 / O00175 / C-C motif chemokine ligand 24ENSG0000010617834


Protein motifs (from Interpro)
Interpro ID Name
 IPR000827  CC chemokine, conserved site
 IPR001811  Chemokine interleukin-8-like domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002548 monocyte chemotaxis IBA
 biological_processGO:0006874 cellular calcium ion homeostasis TAS
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006954 inflammatory response TAS
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007010 cytoskeleton organization IDA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007267 cell-cell signaling TAS
 biological_processGO:0008360 regulation of cell shape IDA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030593 neutrophil chemotaxis IBA
 biological_processGO:0031640 killing of cells of other organism IDA
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0048245 eosinophil chemotaxis IDA
 biological_processGO:0048247 lymphocyte chemotaxis IBA
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide IDA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071346 cellular response to interferon-gamma IBA
 biological_processGO:0071347 cellular response to interleukin-1 IBA
 biological_processGO:0071356 cellular response to tumor necrosis factor IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008009 chemokine activity IEA
 molecular_functionGO:0048020 CCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSG00000121807 CCR2 / P41597 / C-C motif chemokine receptor 2  / complex / reaction
 ENSG00000183625 CCR3 / P51677 / C-C motif chemokine receptor 3  / complex / reaction






 

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