ENSG00000108691


Homo sapiens

Features
Gene ID: ENSG00000108691
  
Biological name :CCL2
  
Synonyms : CCL2 / C-C motif chemokine ligand 2 / P13500
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q12
Gene start: 34255218
Gene end: 34257203
  
Corresponding Affymetrix probe sets: 216598_s_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000225831
Ensembl peptide - ENSP00000462156
NCBI entrez gene - 6347     See in Manteia.
OMIM - 158105
RefSeq - NM_002982
RefSeq Peptide - NP_002973
swissprot - P13500
swissprot - J3KRT7
Ensembl - ENSG00000108691
  
Related genetic diseases (OMIM): 158105 - {Coronary artery disease, modifier of}
  182940 - {Spina bifida, susceptibility to}, 182940
  607948 - {Mycobacterium tuberculosis, susceptibility to}, 607948
  609423 - {HIV-1, resistance to}, 609423
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Ccl2ENSMUSG00000035385Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCL7 / P80098 / C-C motif chemokine ligand 7ENSG0000010868874
CCL11 / P51671 / C-C motif chemokine ligand 11ENSG0000017215670
CCL8 / P80075 / C-C motif chemokine ligand 8ENSG0000010870069
CCL13 / Q99616 / C-C motif chemokine ligand 13ENSG0000018137464
CCL24 / O00175 / C-C motif chemokine ligand 24ENSG0000010617829


Protein motifs (from Interpro)
Interpro ID Name
 IPR000827  CC chemokine, conserved site
 IPR001811  Chemokine interleukin-8-like domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IMP
 biological_processGO:0001525 angiogenesis TAS
 biological_processGO:0002548 monocyte chemotaxis IDA
 biological_processGO:0006468 protein phosphorylation TAS
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0006959 humoral immune response TAS
 biological_processGO:0007010 cytoskeleton organization IDA
 biological_processGO:0007155 cell adhesion TAS
 biological_processGO:0007165 signal transduction NAS
 biological_processGO:0007166 cell surface receptor signaling pathway TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway TAS
 biological_processGO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger TAS
 biological_processGO:0007259 JAK-STAT cascade TAS
 biological_processGO:0008360 regulation of cell shape IDA
 biological_processGO:0009617 response to bacterium NAS
 biological_processGO:0009887 animal organ morphogenesis TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0019079 viral genome replication TAS
 biological_processGO:0019221 cytokine-mediated signaling pathway IDA
 biological_processGO:0019725 cellular homeostasis TAS
 biological_processGO:0030593 neutrophil chemotaxis IBA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IDA
 biological_processGO:0034351 negative regulation of glial cell apoptotic process IDA
 biological_processGO:0035684 helper T cell extravasation ISS
 biological_processGO:0036499 PERK-mediated unfolded protein response TAS
 biological_processGO:0043491 protein kinase B signaling IMP
 biological_processGO:0043524 negative regulation of neuron apoptotic process IDA
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0043615 astrocyte cell migration IDA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEP
 biological_processGO:0048246 macrophage chemotaxis IDA
 biological_processGO:0050870 positive regulation of T cell activation ISS
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process ISS
 biological_processGO:0060326 cell chemotaxis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071222 cellular response to lipopolysaccharide ISS
 biological_processGO:0071346 cellular response to interferon-gamma ISS
 biological_processGO:0071347 cellular response to interleukin-1 ISS
 biological_processGO:0071356 cellular response to tumor necrosis factor IEP
 biological_processGO:0071407 cellular response to organic cyclic compound IDA
 biological_processGO:0090280 positive regulation of calcium ion import IDA
 biological_processGO:2000427 positive regulation of apoptotic cell clearance ISS
 biological_processGO:2000502 negative regulation of natural killer cell chemotaxis IDA
 cellular_componentGO:0005576 extracellular region IDA
 cellular_componentGO:0005615 extracellular space TAS
 cellular_componentGO:0005622 intracellular IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0004672 protein kinase activity TAS
 molecular_functionGO:0005102 signaling receptor binding TAS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008009 chemokine activity TAS
 molecular_functionGO:0031727 CCR2 chemokine receptor binding TAS


Pathways (from Reactome)
Pathway description
ATF4 activates genes
Interleukin-10 signaling
Interleukin-4 and Interleukin-13 signaling


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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