ENSMUSG00000035385


Mus musculus

Features
Gene ID: ENSMUSG00000035385
  
Biological name :Ccl2
  
Synonyms : Ccl2 / C-C motif chemokine 2 / P10148
  
Possible biological names infered from orthology : C-C motif chemokine ligand 2 / P13500
  
Species: Mus musculus
  
Chr. number: 11
Strand: 1
Band: C
Gene start: 82035571
Gene end: 82037453
  
Corresponding Affymetrix probe sets: 10379511 (MoGene1.0st)   1420380_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000000193
NCBI entrez gene - 20296     See in Manteia.
MGI - MGI:98259
RefSeq - NM_011333
RefSeq Peptide - NP_035463
swissprot - P10148
swissprot - Q5SVU3
Ensembl - ENSMUSG00000035385
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CCL2ENSG00000108691Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccl12 / Q62401 / C-C motif chemokine 12 / CCL8* / P80075* / C-C motif chemokine ligand 8*ENSMUSG0000003535232
Ccl7 / Q03366 / C-C motif chemokine 7 / P80098* / C-C motif chemokine ligand 7*ENSMUSG0000003537332
Ccl11 / P48298 / Eotaxin / P51671* / C-C motif chemokine ligand 11*ENSMUSG0000002067632
Ccl8 / Q9Z121 / C-C motif chemokine 8 / P80075* / C-C motif chemokine ligand 8*ENSMUSG0000000918526
Ccl24 / Q9JKC0 / C-C motif chemokine 24 / O00175* / C-C motif chemokine ligand 24*ENSMUSG0000000481424


Protein motifs (from Interpro)
Interpro ID Name
 IPR000827  CC chemokine, conserved site
 IPR001811  Chemokine interleukin-8-like domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis TAS
 biological_processGO:0001666 response to hypoxia IEA
 biological_processGO:0001912 positive regulation of leukocyte mediated cytotoxicity IEA
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IEA
 biological_processGO:0002523 leukocyte migration involved in inflammatory response IEA
 biological_processGO:0002544 chronic inflammatory response IEA
 biological_processGO:0002687 positive regulation of leukocyte migration IEA
 biological_processGO:0002693 positive regulation of cellular extravasation IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007010 cytoskeleton organization ISO
 biological_processGO:0007179 transforming growth factor beta receptor signaling pathway IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007568 aging IEA
 biological_processGO:0008347 glial cell migration IEA
 biological_processGO:0008360 regulation of cell shape ISO
 biological_processGO:0009408 response to heat IEA
 biological_processGO:0009611 response to wounding IDA
 biological_processGO:0009612 response to mechanical stimulus IEA
 biological_processGO:0010332 response to gamma radiation IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010574 regulation of vascular endothelial growth factor production IMP
 biological_processGO:0010759 positive regulation of macrophage chemotaxis IEA
 biological_processGO:0014823 response to activity IEA
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0022409 positive regulation of cell-cell adhesion IEA
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0031100 animal organ regeneration IEA
 biological_processGO:0031640 killing of cells of other organism ISO
 biological_processGO:0032496 response to lipopolysaccharide IEA
 biological_processGO:0032570 response to progesterone IEA
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IEA
 biological_processGO:0032869 cellular response to insulin stimulus IEA
 biological_processGO:0032967 positive regulation of collagen biosynthetic process IEA
 biological_processGO:0033552 response to vitamin B3 IEA
 biological_processGO:0034612 response to tumor necrosis factor IEA
 biological_processGO:0035684 helper T cell extravasation IDA
 biological_processGO:0035690 cellular response to drug IEA
 biological_processGO:0035702 monocyte homeostasis TAS
 biological_processGO:0036006 cellular response to macrophage colony-stimulating factor stimulus IEA
 biological_processGO:0036120 cellular response to platelet-derived growth factor stimulus IEA
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043200 response to amino acid IEA
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0043615 astrocyte cell migration ISS
 biological_processGO:0045471 response to ethanol IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0046677 response to antibiotic IEA
 biological_processGO:0048010 vascular endothelial growth factor receptor signaling pathway IEA
 biological_processGO:0048245 eosinophil chemotaxis ISO
 biological_processGO:0048246 macrophage chemotaxis IEA
 biological_processGO:0048247 lymphocyte chemotaxis IEA
 biological_processGO:0050806 positive regulation of synaptic transmission IEA
 biological_processGO:0050870 positive regulation of T cell activation IMP
 biological_processGO:0051384 response to glucocorticoid IEA
 biological_processGO:0051770 positive regulation of nitric-oxide synthase biosynthetic process IMP
 biological_processGO:0060135 maternal process involved in female pregnancy IEA
 biological_processGO:0060137 maternal process involved in parturition IEA
 biological_processGO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide ISO
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:0071300 cellular response to retinoic acid IEA
 biological_processGO:0071318 cellular response to ATP IEA
 biological_processGO:0071333 cellular response to glucose stimulus IEA
 biological_processGO:0071346 cellular response to interferon-gamma IDA
 biological_processGO:0071347 cellular response to interleukin-1 IDA
 biological_processGO:0071354 cellular response to interleukin-6 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IDA
 biological_processGO:0071392 cellular response to estradiol stimulus IEA
 biological_processGO:0071398 cellular response to fatty acid IEA
 biological_processGO:0071402 cellular response to lipoprotein particle stimulus IEA
 biological_processGO:0071403 cellular response to high density lipoprotein particle stimulus IEA
 biological_processGO:0071549 cellular response to dexamethasone stimulus IEA
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IEA
 biological_processGO:0090265 positive regulation of immune complex clearance by monocytes and macrophages IMP
 biological_processGO:0090303 positive regulation of wound healing IEA
 biological_processGO:0090314 positive regulation of protein targeting to membrane IEA
 biological_processGO:1905237 response to cyclosporin A IEA
 biological_processGO:2000427 positive regulation of apoptotic cell clearance IDA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005791 rough endoplasmic reticulum IEA
 cellular_componentGO:0030139 endocytic vesicle IEA
 cellular_componentGO:0030425 dendrite IEA
 cellular_componentGO:0043025 neuronal cell body IEA
 cellular_componentGO:0043204 perikaryon IEA
 cellular_componentGO:0043679 axon terminus IEA
 cellular_componentGO:0044299 C-fiber IEA
 cellular_componentGO:0045202 synapse IEA
 cellular_componentGO:0048471 perinuclear region of cytoplasm IEA
 molecular_functionGO:0001664 G-protein coupled receptor binding IDA
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008009 chemokine activity IBA
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0031727 CCR2 chemokine receptor binding IPI


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000122 accelerated tooth eruption "early onset of the growth of the teeth out of the gums" [J:65045]
Show

Allelic Composition: Cxadrtm2Know/Cxadr+
Genetic Background: involves: 129 * Black Swiss

 MP:0000136 abnormal microglial cell morphology "anomalous structure, number, or composition of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [ava:Anna V. Anagnostopoulos , Mouse Genome Informatics Curator, J:71688]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0000219 increased neutrophil count "greater than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cxadrtm2Know/Cxadr+
Genetic Background: involves: 129 * Black Swiss

 MP:0000221 decreased WBC count "fewer than normal numbers of WBCs" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cxadrtm2Know/Cxadr+
Genetic Background: involves: 129 * Black Swiss

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Cxcr3tm1Wwh/Y
Genetic Background: B6.Cg-Cxcr3tm1Wwh

 MP:0000759 abnormal skeletal muscle morphology "anomalous structure of any of the striated muscle fibers connected at either or both extremeties with the bony framework of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cxadrtm2Know/Cxadr+
Genetic Background: involves: 129 * Black Swiss

 MP:0000921 demyelination "loss of the myelin sheath without loss of axons or fiber tracts" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Ccl2tm1Rol/Ccl2+,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Ccl2tm1Rol/Ccl2+,Tg(PMP22)C61Clh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/Ca

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Tg(PMP22)C61Clh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/Ca

 MP:0001262 decreased body weight "lower than normal average weight " [J:61295]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0001325 abnormal retina morphology "structural or developmental anomaly of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fsttm1Zuk/Fst+
Genetic Background: involves: 129S7/SvEvBrd * C57BL/6

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
Show

Allelic Composition: Cxadrtm2Know/Cxadr+
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0001504 abnormal posture "atypical position of the limbs or carriage of the body" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:18984]
Show

Allelic Composition: Fcer1atm1Ftl/Fcer1atm1Ftl
Genetic Background: CBy.129S2-Fcer1atm1Ftl

 MP:0001515 abnormal grip strength "altered ability to grasp and hold objects, usually measured as time spent hanging from an object or wire" [J:80661]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2+,Tg(PMP22)C61Clh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/Ca

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Cxadrtm2Know/Cxadr+
Genetic Background: involves: 129 * Black Swiss

 MP:0001552 increased circulating triglyceride level "higher than normal concentration of triacylglycerols in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, J:65416]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fcer1atm1Ftl/Fcer1atm1Ftl
Genetic Background: CBy.129S2-Fcer1atm1Ftl

 MP:0001935 reduced litter size "fewer live born pups in a litter compared to average" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

 MP:0001987 alcohol preference 
Show

Allelic Composition: Cxadrtm2Know/Cxadr+
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0002079 increased circulating insulin level "greater than normal levels of insulin in blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0002128 abnormal blood circulation "failure or atypical movement in the flow of blood from the heart to the vasculature and back to the heart" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Cxadrtm2Know/Cxadr+
Genetic Background: involves: 129 * Black Swiss

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zbtb7btm7Itan/Zbtb7btm7Itan
Genetic Background: Not Specified

 MP:0002310 resistance to fatty liver development "less likely than the norm to to develop hepatic steatosis " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0002376 abnormal dendritic cell physiology "failure or atypical function of the immunocompetent cells of the lymphoid and hemopoietic systems and skin, which function to process antigens and present them to T cells, thus stimulating cellular immunity" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, J:85808]
Show

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Nespastm1Jop/Nespastm1.1Jop
Genetic Background: involves: 129S/SvEv * 129S1/Sv

Allelic Composition: Ccl2tm1.1Pame/Ccl2tm1.1Pame,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

 MP:0002444 abnormal T cell physiology "anomalous response of T lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cxcr3tm1Wwh/Y
Genetic Background: B6.Cg-Cxcr3tm1Wwh

 MP:0002451 abnormal macrophage physiology "abnormal function or response of the phagocytic leukocytes involved in innate immunity, early non-adaptive phases of host-defense, antigen presentation, and which act as effector cells in humoral and cell-mediated immunity" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Fcer1atm1Ftl/Fcer1atm1Ftl
Genetic Background: CBy.129S2-Fcer1atm1Ftl

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0002463 abnormal neutrophil physiology "abnormal function of these granular leukocytes, which stain with neutral dyes" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cxadrtm2Know/Cxadr+
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Ccl2tm1.1Tyos/Ccl2tm1.1Tyos
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Cxadrtm2Know/Cxadr+
Genetic Background: involves: 129 * Black Swiss

 MP:0002570 alcohol aversion 
Show

Allelic Composition: Cxadrtm2Know/Cxadr+
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0002620 abnormal monocyte morphology "anomalous structure, number, or development of the white blood cells that are precursors to macrophages" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0002702 decreased circulating free fatty acid level "lower than normal levels of unesterified fatty acids in the blood" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0002727 decreased circulating insulin level "less than normal levels of insulin in the blood" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, dlb:Donna Burkart , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0002805 abnormal conditioned taste aversion behavior "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0002891 increased insulin sensitivity "greater ability to clear glucose from the bloodstream when given insulin than normal; can result in hypoglycemia" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0002908 delayed wound healing "longer time requirement for the ability to self-repair and close wounds than normal" [J:63037]
Show

Allelic Composition: Ehmt1tm1.2Tara/Ehmt1+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
Show

Allelic Composition: Nespastm1Jop/Nespastm1.1Jop
Genetic Background: involves: 129S/SvEv * 129S1/Sv

Allelic Composition: Ccl2tm1.1Pame/Ccl2tm1.1Pame,Tg(Tek-cre)12Flv/0
Genetic Background: involves: C3H * C57BL/6

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Tg(Ccr2-GFP)8Pam/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J

 MP:0003224 neuron degeneration "a retrogressive impairment of function or destruction of the functional cells of the nervous system that receive, conduct, and transmit impulses " [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Ccl2tm1Rol/Ccl2+,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003383 abnormal gluconeogenesis "anomaly in the formation of glucose from noncarbohydrates, such as proteins or fat" [J:93896]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0003397 increased muscle weight "greater than average muscle weight" [J:94134, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0003545 increased alcohol consumption "greater than normal consumption of alcohol" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0003546 decreased alcohol consumption "less than normal consumption of alcohol" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0003710 abnormal physiological neovascularization "anomalies in the development of new blood vessels in restoration of blood circulation during the healing process " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Cxcr3tm1Wwh/Y
Genetic Background: B6.Cg-Cxcr3tm1Wwh

 MP:0003730 abnormal photoreceptor inner segments "malformation/anomalous structure of the photoreceptor layer which contains the machinery of the cell (mitochondria, golgi, endoplasmic reticulum, etc)" [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

Allelic Composition: Ccl2tm1.1Tyos/Ccl2tm1.1Tyos
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0003852 skeletal muscle necrosis "pathological cell death in the skeletal muscle, usually due to irreversible damage" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: (129S4/SvJae x C57BL/6)F1

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Ccl2tm1Rol/Ccl2+,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0003921 abnormal left ventricle morphology "structural anomaly of the left lower chamber of the heart " [smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004502 decreased incidence of chemically-induced tumors "lower than normal frequency of tumor incidence induced by one or more chemical carcinogens or mutagens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: SJL.129S4-Ccl2tm1Rol

 MP:0004892 increased adiponectin level "greater level of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0004984 increased osteoclast cell number "greater than average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0005016 decreased lymphocyte number "fewer than normal white blood cell numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0005027 increased susceptibility to parasitic infection "greater likelihood that an organism will develop ill effects from a parasitic infection or from components of or toxins produced by parasites " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0005098 abnormal choroid morphology "anomalous structure of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cxadrtm2Know/Cxadr+
Genetic Background: involves: 129 * Black Swiss

 MP:0005103 abnormal retinal pigmentation "anomalous coloring of the thin layer of neural tissue lining the back of the eyeball which contains visual receptors " [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0005145 increased circulating VLDL cholesterol level "greater than average concentration in the blood of very low density lipoprotein, which normally transports triglycerides from the intestine and liver to muscle and adipose tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0005164 abnormal response to injury "anomaly in the body s reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Cxadrtm2Know/Cxadr+
Genetic Background: involves: 129 * Black Swiss

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: (129S4/SvJae x C57BL/6)F1

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0005239 abnormal Bruch membrane morphology "anomalous structure of the transparent, nearly structureless inner layer of the choroid in contact with the pigmented layer of the retina" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0005240 abnormal amacrine cell morphology "anomalous structure of the interneurons of the retina" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0005292 improved glucose tolerance "better than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin sensitivity; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0005293 impaired glucose tolerance "less than the normal response to oral consumption or intravenous injection of specified amounts of glucose and indicative of insulin resistance; measured by determining whole blood or plasma sugar level in a fasting state before and after taking glucose at specified intervals" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0005335 abnormal gonadal fat pad "malformed or aberrant size of the encapsulated adipose tissue associated with the ovaries or testes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:84541]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ldlrtm1Her/Ldlrtm1Her
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6

 MP:0005402 abnormal action potential "change in the electric response of a nerve or other excitable tissue to its stimulation" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Tg(PMP22)C61Clh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/Ca

 MP:0005425 increased macrophage count "greater than the normal numbers of macrophages" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:73418]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

Allelic Composition: Ccl2tm1Rol/Ccl2+,Tg(PMP22)C61Clh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/Ca

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Tg(PMP22)C61Clh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/Ca

 MP:0005458 increased percent body fat "more fat, relative to the norm, as a percentage of total body weight" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0005546 choroidal neovascularization "new, abnormal, vessel development of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0005547 abnormal Muller cell morphology "anomalous structure of the elongated neuroglial cells that traverse all the layers of the retina and that act as supporting elements" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0005548 retinal pigment epithelium atrophy "wasting or decreased size of the epithelial layer of the retina composed of cells containing pigment granules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0005549 retinal pigment epithelium hyperplasia "increased numbers of cells in the epithelial layer of the retina composed of cells containing pigment granules " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

 MP:0005559 increased circulating glucose level "greater than the normal concentration in the blood of this major monosaccharide of the body; it is an important energy source" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, RGD:Rat Genome Database submission]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0005590 increased vasodilation "greater than the expected or normal widening of the lumen of the blood vessels" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0005602 decreased angiogenesis "reduced process of blood vessel formation and the subsequent remodeling process; does not refer to the initial establishment of the vascular network" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Ehmt1tm1.2Tara/Ehmt1+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0005658 susceptibility to diet-induced obesity "more likely to become excessively fat or to increase fat in the subcutaneous connective tissue as a result of consuming a diet geared to increase body fat " [cwg:Carroll-Ann W. Goldsmith, Mouse Genome Informatics curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0006187 retinal deposits "abnormal accumulation of material on the retina" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0006238 abnormal choriocapillaris morphology "malformation of the capillaries forming the inner vascular layer of the choroid of the eye" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0006319 abnormal epididymal fat pad "any structural anomaly of the encapsulated adipose tissue associated with the epididymis" [MGI:rbabiuk "Randall Babiuk, Mouse Genome Informatics Curator", MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0008074 increased CD4-positive T cell number "greater number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0008127 decreased dendritic cell number "reduction in the number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0008236 decreased susceptibility to neuronal excitotoxicity "less than normal amount of neuronal cell death following exposure to a neurotoxic compound, such as kaniate-induced neuronal cell death mediated via a glutamate excitotoxic process" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0008243 abnormal foam cell morphology "any structural anomaly of a type of macrophage containing lipids in small vacuoles and typically seen in atherolosclerotic lesions, as well as other conditions" [CL:0000517]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2+,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008553 increased circulating tumor necrosis factor level "greater amount in the blood of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0008577 increased circulating interferon-gamma level "increase in the amount in the blood of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0008586 disorganized photoreceptor outer segment "derangement of the pattern of the photoreceptor region that is rich in the visual pigment rhodopsin" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

 MP:0008593 increased circulating interleukin-10 level "increase in the amount in the blood of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0008670 decreased interleukin-12b secretion "reduction in the production or release of the p40 cytokine subunit that is a component of both interleukin-12 and interleukin-23" [MESH:D12.644.276.374.465.512.500]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008700 decreased interleukin-4 secretion "reduction in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008703 decreased interleukin-5 secretion "reduction in the production or release of a cytokine that promotes differentiation and activation of eosinophils; it also triggers activated B-cells to differentiate into immunoglobulin-secreting cells" [MESH:D12.644.276.374.465.505]
Show

Allelic Composition: Prlrtm1Cnp/Prlr+
Genetic Background: involves: 129P2/OlaHsd

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Mpztm1Msch/Mpz+
Genetic Background: involves: 129S4/SvJae * 129S7/SvEvBrd

 MP:0008721 abnormal chemokine level "deviation from the normal levels of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

Allelic Composition: Ccl2tm1.1Tyos/Ccl2tm1.1Tyos
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ccl2tm1Tyos/Ccl2tm1Tyos
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

Allelic Composition: Ccl2tm1.1Tyos/Ccl2tm1.1Tyos
Genetic Background: involves: 129S1/Sv * C57BL/6

Allelic Composition: Ccl2tm1Tyos/Ccl2tm1Tyos
Genetic Background: involves: 129S1/Sv * C57BL/6

 MP:0008814 reduced nerve conduction velocity "decrease in the rate at which an eletrical impulse travels through a nerve" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Tg(PMP22)C61Clh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/Ca

 MP:0008842 lipofuscinosis "storage in organs of brownish fatty pigment resulting from the breakdown and absorption of damaged blood cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0008874 decreased sensitivity to xenobiotics "increase in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0008908 increased total fat pad weight "greater than average weight of the fat pads" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0009269 decreased fat cell size "reduction in the size of fat-storing cells found mostly in the abdominal cavity and subcutaneous tissue of mammals" [CL:0000449]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0009767 decreased sensitivity to xenobiotic induced morbidity/mortality "increase in the amount of a foreign compound required to cause death or diseased state" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009787 increased susceptibility to infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a pathogenic invasion or from components of or toxins produced by pathogens" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0010016 variable depigmentation "absence or loss of normal pigment in the skin in various and irregular patterns" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Zm/Cx3cr1tm1Zm
Genetic Background: involves: 129 * 129S4/SvJae

 MP:0010053 decreased grip strength "reduced ability to grasp and hold objects, often measured as time spent hanging from an object or wire" [ISBN:0471316393 "Crawley, JN, What s Wrong with my Mouse: Behavioral Phenotyping of Transgenic and Knockout Mice"]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2+,Tg(PMP22)C61Clh/0
Genetic Background: involves: 129S4/SvJae * C57BL/6J * CBA/Ca

 MP:0010740 abnormal dendritic cell chemotaxis "anomaly in the movement of a dendritic cell in response to an external stimulus" [GO:0002407]
Show

Allelic Composition: Pmp22Tr-2J/Pmp22+
Genetic Background: C57BL/6J-Pmp22Tr-2J/GrsrJ

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0013237 abnormal skeletal muscle regeneration "anomaly in the ability to repair skeletal muscle after injury or disease" [MGI:csmith]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: B6.129S4-Ccl2tm1Rol

 MP:0020448 increased microglial cell activation "increase in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]
Show

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr