ENSMUSG00000004814


Mus musculus

Features
Gene ID: ENSMUSG00000004814
  
Biological name :Ccl24
  
Synonyms : Ccl24 / C-C motif chemokine 24 / Q9JKC0
  
Possible biological names infered from orthology : C-C motif chemokine ligand 24 / O00175
  
Species: Mus musculus
  
Chr. number: 5
Strand: -1
Band: G2
Gene start: 135569937
Gene end: 135573049
  
Corresponding Affymetrix probe sets: 10534493 (MoGene1.0st)   1450488_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000004936
Ensembl peptide - ENSMUSP00000144002
NCBI entrez gene - 56221     See in Manteia.
MGI - MGI:1928953
RefSeq - XM_006504445
RefSeq - NM_019577
RefSeq - XM_006504444
RefSeq Peptide - NP_001343559
RefSeq Peptide - NP_062523
swissprot - Q3U0A4
swissprot - Q9JKC0
Ensembl - ENSMUSG00000004814
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CCL24ENSG00000106178Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccl2 / P10148 / C-C motif chemokine 2 / P13500* / C-C motif chemokine ligand 2*ENSMUSG0000003538530
Ccl7 / Q03366 / C-C motif chemokine 7 / P80098* / C-C motif chemokine ligand 7*ENSMUSG0000003537326
Ccl11 / P48298 / Eotaxin / P51671* / C-C motif chemokine ligand 11*ENSMUSG0000002067626
Ccl8 / Q9Z121 / C-C motif chemokine 8 / P80075* / C-C motif chemokine ligand 8*ENSMUSG0000000918524
Ccl12 / Q62401 / C-C motif chemokine 12 / CCL8* / P80075* / C-C motif chemokine ligand 8*ENSMUSG0000003535224


Protein motifs (from Interpro)
Interpro ID Name
 IPR000827  CC chemokine, conserved site
 IPR001811  Chemokine interleukin-8-like domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation ISO
 biological_processGO:0002548 monocyte chemotaxis IBA
 biological_processGO:0006935 chemotaxis IDA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007010 cytoskeleton organization ISO
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0008360 regulation of cell shape ISO
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030335 positive regulation of cell migration ISO
 biological_processGO:0030593 neutrophil chemotaxis IBA
 biological_processGO:0030838 positive regulation of actin filament polymerization ISO
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0045766 positive regulation of angiogenesis IMP
 biological_processGO:0048245 eosinophil chemotaxis ISO
 biological_processGO:0048247 lymphocyte chemotaxis IBA
 biological_processGO:0050729 positive regulation of inflammatory response IMP
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071346 cellular response to interferon-gamma IBA
 biological_processGO:0071347 cellular response to interleukin-1 IBA
 biological_processGO:0071356 cellular response to tumor necrosis factor IBA
 biological_processGO:2000418 positive regulation of eosinophil migration IMP
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 molecular_functionGO:0005125 cytokine activity IDA
 molecular_functionGO:0008009 chemokine activity IBA
 molecular_functionGO:0031728 CCR3 chemokine receptor binding ISO
 molecular_functionGO:0048018 receptor ligand activity ISO
 molecular_functionGO:0048020 CCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0001790 abnormal immune system physiology "deviation from the normal function of the immune system " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Acvrl1tm1Dgen/Acvrl1tm1Dgen
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0001845 abnormal inflammatory response "aberrant reaction of the microcirculation characterized by movement of fluid and leukocytes from the blood into extravascular tissues" [Pathology:ISBN 0-397-51047-0]
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Allelic Composition: Ccl11tm1Mer/Ccl11tm1Mer,Ccl24tm1Mer/Ccl24tm1Mer
Genetic Background: 129S.129S6(Cg)-Ccl24tm1Mer Ccl11tm1Mer

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Gata1tm6Sho/Gata1tm6Sho
Genetic Background: involves: 129S1/Sv * BALB/c

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gata1tm6Sho/Gata1tm6Sho
Genetic Background: involves: 129S1/Sv * BALB/c

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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