ENSG00000108700


Homo sapiens

Features
Gene ID: ENSG00000108700
  
Biological name :CCL8
  
Synonyms : CCL8 / C-C motif chemokine ligand 8 / P80075
  
Possible biological names infered from orthology :
  
Species: Homo sapiens
  
Chr. number: 17
Strand: 1
Band: q12
Gene start: 34319036
Gene end: 34321402
  
Corresponding Affymetrix probe sets: 214038_at (Human Genome U133 Plus 2.0 Array)   
  
Cross references: Ensembl peptide - ENSP00000378118
NCBI entrez gene - 6355     See in Manteia.
OMIM - 602283
RefSeq - NM_005623
RefSeq Peptide - NP_005614
swissprot - P80075
Ensembl - ENSG00000108700
  
See expression report in BioGPS
See gene description in Wikigenes
See gene description in GeneCards
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 Ccl12ENSMUSG00000035352Mus musculus
 Ccl8ENSMUSG00000009185Mus musculus


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
CCL2 / P13500 / C-C motif chemokine ligand 2ENSG0000010869169
CCL11 / P51671 / C-C motif chemokine ligand 11ENSG0000017215669
CCL7 / P80098 / C-C motif chemokine ligand 7ENSG0000010868865
CCL13 / Q99616 / C-C motif chemokine ligand 13ENSG0000018137461
CCL24 / O00175 / C-C motif chemokine ligand 24ENSG0000010617831


Protein motifs (from Interpro)
Interpro ID Name
 IPR000827  CC chemokine, conserved site
 IPR001811  Chemokine interleukin-8-like domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002548 monocyte chemotaxis IBA
 biological_processGO:0002687 positive regulation of leukocyte migration IEA
 biological_processGO:0006468 protein phosphorylation IEA
 biological_processGO:0006816 calcium ion transport IDA
 biological_processGO:0006874 cellular calcium ion homeostasis IDA
 biological_processGO:0006887 exocytosis IDA
 biological_processGO:0006935 chemotaxis TAS
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction TAS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007267 cell-cell signaling IDA
 biological_processGO:0009615 response to virus TAS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0030593 neutrophil chemotaxis IBA
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0048247 lymphocyte chemotaxis IBA
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0070664 negative regulation of leukocyte proliferation IEA
 biological_processGO:0071346 cellular response to interferon-gamma IBA
 biological_processGO:0071347 cellular response to interleukin-1 IBA
 biological_processGO:0071356 cellular response to tumor necrosis factor IBA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IBA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0004672 protein kinase activity IDA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008009 chemokine activity TAS
 molecular_functionGO:0008201 heparin binding IEA
 molecular_functionGO:0016004 phospholipase activator activity IDA
 molecular_functionGO:0048020 CCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
No match
  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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