ENSMUSG00000049103


Mus musculus

Features
Gene ID: ENSMUSG00000049103
  
Biological name :Ccr2
  
Synonyms : C-C chemokine receptor type 2 / Ccr2 / P51683
  
Possible biological names infered from orthology : C-C motif chemokine receptor 2 / P41597
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F4
Gene start: 124101950
Gene end: 124113557
  
Corresponding Affymetrix probe sets: 10590631 (MoGene1.0st)   1421186_at (Mouse Genome 430 2.0 Array)   1421187_at (Mouse Genome 430 2.0 Array)   1421188_at (Mouse Genome 430 2.0 Array)   1460067_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000049909
Ensembl peptide - ENSMUSP00000128734
Ensembl peptide - ENSMUSP00000130112
Ensembl peptide - ENSMUSP00000132453
NCBI entrez gene - 12772     See in Manteia.
MGI - MGI:106185
RefSeq - XM_011243064
RefSeq - NM_009915
RefSeq - XM_006512428
RefSeq - XM_011243063
RefSeq Peptide - NP_034045
swissprot - P51683
swissprot - Q543S8
Ensembl - ENSMUSG00000049103
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccr11.1ENSDARG00000070755Danio rerio
 ccr2ENSDARG00000105363Danio rerio
 ccr2ENSDARG00000079829Danio rerio
 CCR2ENSGALG00000011733Gallus gallus
 CCR5ENSGALG00000037077Gallus gallus
 CCR2ENSG00000121807Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccr5 / P51682 / C-C chemokine receptor type 5 / P51681* / C-C motif chemokine receptor 5 (gene/pseudogene)*ENSMUSG0000007922773
Ccr3 / P51678 / Probable C-C chemokine receptor type 3 / P51677* / C-C motif chemokine receptor 3*ENSMUSG0000003544852
Ccr1 / P51675 / C-C chemokine receptor type 1 / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000002580451
Ccr4 / P51680 / C-C chemokine receptor type 4 / P51679* / C-C motif chemokine receptor 4*ENSMUSG0000004789847
Ccr1l1 / P51676 / C-C chemokine receptor 1-like protein 1 / CCR1* / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000006403943
Cx3cr1 / Q9Z0D9 / CX3C chemokine receptor 1 / P49238* / C-X3-C motif chemokine receptor 1*ENSMUSG0000005233642
Ccr8 / P56484 / C-C chemokine receptor type 8 / P51685* / C-C motif chemokine receptor 8*ENSMUSG0000004226238
Ackr2 / O08707 / atypical chemokine receptor 2 / O00590*ENSMUSG0000004453434
Ccr9 / Q9WUT7 / C-C chemokine receptor type 9 / P51686* / C-C motif chemokine receptor 9*ENSMUSG0000002953032
Ccr6 / O54689 / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA. / P51684* / C-C motif chemokine receptor 6*ENSMUSG0000004089931
Cxcr3 / O88410 / C-X-C chemokine receptor type 3 / P49682* / C-X-C motif chemokine receptor 3*ENSMUSG0000005023231
Ccr7 / P47774 / C-C chemokine receptor type 7 / P32248* / C-C motif chemokine receptor 7*ENSMUSG0000003794431
Xcr1 / chemokine (C motif) receptor 1 / P46094* / X-C motif chemokine receptor 1*ENSMUSG0000006050930
Cxcr2 / P35343 / C-X-C chemokine receptor type 2 / P25025* / C-X-C motif chemokine receptor 2*ENSMUSG0000002618029
Cxcr1 / Q810W6 / C-X-C chemokine receptor type 1 / P25024* / C-X-C motif chemokine receptor 1*ENSMUSG0000004848028
Cxcr6 / Q9EQ16 / C-X-C chemokine receptor type 6 / O00574* / C-X-C motif chemokine receptor 6*ENSMUSG0000004852128
Ackr4 / Q924I3 / atypical chemokine receptor 4 / Q9NPB9*ENSMUSG0000007935527
Ccr10 / Q9JL21 / C-C chemokine receptor type 10 / P46092* / C-C motif chemokine receptor 10*ENSMUSG0000004405227
Cxcr4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073* / C-X-C motif chemokine receptor 4*ENSMUSG0000004538227
Cxcr5 / Q04683 / C-X-C chemokine receptor type 5 / P32302* / C-X-C motif chemokine receptor 5*ENSMUSG0000004788027


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR002237  CC chemokine receptor 2
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001525 angiogenesis TAS
 biological_processGO:0001974 blood vessel remodeling ISS
 biological_processGO:0002246 wound healing involved in inflammatory response NAS
 biological_processGO:0002548 monocyte chemotaxis IMP
 biological_processGO:0002827 positive regulation of T-helper 1 type immune response IMP
 biological_processGO:0002829 negative regulation of type 2 immune response IMP
 biological_processGO:0006874 cellular calcium ion homeostasis ISS
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response IMP
 biological_processGO:0006955 immune response IMP
 biological_processGO:0006959 humoral immune response IMP
 biological_processGO:0006968 cellular defense response IMP
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0010574 regulation of vascular endothelial growth factor production IMP
 biological_processGO:0010820 positive regulation of T cell chemotaxis IDA
 biological_processGO:0016525 negative regulation of angiogenesis IMP
 biological_processGO:0019221 cytokine-mediated signaling pathway IEA
 biological_processGO:0019233 sensory perception of pain IMP
 biological_processGO:0019725 cellular homeostasis IDA
 biological_processGO:0030097 hemopoiesis IMP
 biological_processGO:0030334 regulation of cell migration IMP
 biological_processGO:0032729 positive regulation of interferon-gamma production IMP
 biological_processGO:0032743 positive regulation of interleukin-2 production IMP
 biological_processGO:0035705 T-helper 17 cell chemotaxis IDA
 biological_processGO:0042535 positive regulation of tumor necrosis factor biosynthetic process IMP
 biological_processGO:0043277 apoptotic cell clearance IC
 biological_processGO:0043310 negative regulation of eosinophil degranulation IMP
 biological_processGO:0045627 positive regulation of T-helper 1 cell differentiation IC
 biological_processGO:0046641 positive regulation of alpha-beta T cell proliferation IMP
 biological_processGO:0048873 homeostasis of number of cells within a tissue IMP
 biological_processGO:0050729 positive regulation of inflammatory response IDA
 biological_processGO:0050870 positive regulation of T cell activation IMP
 biological_processGO:0061756 leukocyte adhesion to vascular endothelial cell IMP
 biological_processGO:0070098 chemokine-mediated signaling pathway ISS
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IMP
 biological_processGO:0090265 positive regulation of immune complex clearance by monocytes and macrophages IMP
 biological_processGO:0097350 neutrophil clearance IMP
 biological_processGO:1903238 positive regulation of leukocyte tethering or rolling IMP
 biological_processGO:2000439 positive regulation of monocyte extravasation IMP
 biological_processGO:2000451 positive regulation of CD8-positive, alpha-beta T cell extravasation IMP
 biological_processGO:2000464 positive regulation of astrocyte chemotaxis ISO
 biological_processGO:2000473 positive regulation of hematopoietic stem cell migration IMP
 cellular_componentGO:0005737 cytoplasm IEA
 cellular_componentGO:0005829 cytosol ISS
 cellular_componentGO:0005886 plasma membrane ISO
 cellular_componentGO:0005887 integral component of plasma membrane TAS
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 cellular_componentGO:0030425 dendrite ISS
 cellular_componentGO:0043025 neuronal cell body ISS
 cellular_componentGO:0043204 perikaryon ISS
 cellular_componentGO:0048471 perinuclear region of cytoplasm ISS
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016493 C-C chemokine receptor activity IDA
 molecular_functionGO:0019955 cytokine binding IPI
 molecular_functionGO:0031727 CCR2 chemokine receptor binding IEA
 molecular_functionGO:0035715 chemokine (C-C motif) ligand 2 binding IPI
 molecular_functionGO:0035716 chemokine (C-C motif) ligand 12 binding IPI
 molecular_functionGO:0035717 chemokine (C-C motif) ligand 7 binding IPI
 molecular_functionGO:0042803 protein homodimerization activity ISS


Pathways (from Reactome)
Pathway description
Beta defensins
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000130 abnormal cancellous bone morphology "structural anomaly of bone that has a latticelike or spongy structure" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr2tm1Ifc/Ccr2+,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: B6.Cg-Apoetm1Unc Ccr2tm1Ifc

Allelic Composition: Ccr2tm1.1Mpa/Ccr2tm1.1Mpa
Genetic Background: involves: BALB/cJ * C57BL/6

 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kiss1rtm1Gstn/Kiss1rtm1Gstn
Genetic Background: involves: 129P2/OlaHsd

 MP:0000599 enlarged liver "larger than average size of the liver" [J:65146]
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Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

 MP:0000604 amyloidosis "an accumulation of extracellular amyloid in tissues of the body" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr2tm1Ifc/Ccr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0000689 abnormal spleen morphology "atypical structure of the organ that functions to filter blood and to store red corpuscles and platelets" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:27463]
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Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

 MP:0000691 enlarged spleen "increased spleen size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

 MP:0000702 enlarged lymph nodes "lymph nodes of increased size" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

 MP:0000717 abnormal lymphocyte number "deviation from the normal number of white blood cells" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

 MP:0001263 weight loss "progressive reduction of body weight below normal average for age" [J:45400]
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Allelic Composition: Nfkbiatm1Fey/Nfkbiatm1Fey
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0001326 retinal degeneration "pathological change in the thin layer of neural tissue lining the back of the eyeball, which contains visual receptors and can result in the impairment or cessation of retinal neural function" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, NMF:Stephanie Pretel, Neuroscience Mutagenesis Facility Curator]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0001541 abnormal osteoclast function "reduced ability or inability of osteoclasts to absorb and remove osseous tissue" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:58795]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0001654 hepatic necrosis "pathologic death of cells within, or a portion of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001655 multifocal hepatic necrosis "multiple localized areas of pathologic death of cells within, or portions of, the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

 MP:0001859 kidney inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the kidney" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

 MP:0001860 liver inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the liver" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkbiatm1Fey/Nfkbiatm1Fey
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0001915 intracranial hemorrhage "bleeding within the skull, including hemorrhage into the brain and within the cranial epidural, subdural, and subarachnoid spaces" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0001987 alcohol preference 
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0002078 abnormal glucose homeostasis "anomaly in the state of equilibrium or processing in the body with respect to glucose in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ropn1Gt(OST21705)Lex/Ropn1Gt(OST21705)Lex,Ropn1lGt(OST20298)Lex/Ropn1lGt(OST20298)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Wrntm1Led/Wrn+
Genetic Background: involves: 129S6/SvEvTac * Black Swiss

Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

Allelic Composition: Ccr2tm1Ifc/Ccr2+,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0002118 abnormal lipid homeostasis "anomaly in the state of equilibrium in the body with respect to lipids in the fluids and tissues" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Sec61a1m1Gek/Sec61a1m1Gek,Tg(Ins2-Sec61a1)#Gek/0
Genetic Background: C57BL/6-Sec61a1m1Gek Tg(Ins2-Sec61a1)#Gek

 MP:0002335 decreased airway responsiveness "less easily provoked into bronchoconstriction during bronchial provocation testing" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

 MP:0002418 increased susceptibility to viral infection "greater likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

Allelic Composition: Ccr2tm2.1Ifc/Ccr2tm2.1Ifc,Cx3cr1tm1Litt/Cx3cr1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ccr2tm2.1Ifc/Ccr2tm2.1Ifc,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0002446 abnormal macrophage morphology "anomalous structure, number, or composition of the large mononuclear phagocytic cells found in most tissues of the body" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ropn1Gt(OST21705)Lex/Ropn1Gt(OST21705)Lex,Ropn1lGt(OST20298)Lex/Ropn1lGt(OST20298)Lex
Genetic Background: involves: 129S5/SvEvBrd

 MP:0002493 increased IgG "greater than normal immunoglobulin class G level" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0002570 alcohol aversion 
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0002620 abnormal monocyte morphology "anomalous structure, number, or development of the white blood cells that are precursors to macrophages" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol
Genetic Background: involves: 129S4/SvJae

 MP:0002722 abnormal immune system organ morphology "anomalous structure/organization or development of lymphoid organs" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

 MP:0002723 abnormal immune serum protein physiology "abnormal concentration or function of circulating immune proteins" [cwg:Carroll W. Goldsmith , Mouse Genome Informatics Curator]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0002743 glomerulonephritis "glomerular disease characterized by diffuse inflammatory reaction that is not the acute response to infection of the kidneys" [Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8, pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

 MP:0002805 abnormal conditioned taste aversion behavior "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0002871 albuminuria "presence of excess albumin in the urine" [RGD:Rat Genome Database submission, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

 MP:0002941 increased circulating alanine transaminase level "increased concentration in the blood of this enzyme, which transfers amino groups from l-alanine to 2 ketoglutarate, or the reverse (from l-glutamate to pyruvate); serum concentration is increased in viral hepatitis and myocardial infarction" [pvb:Pierre Vanden Borre , Mouse Genome Informatics Curator, Stedman s Medical Dictionary , 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Nfkbiatm1Fey/Nfkbiatm1Fey
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd

 MP:0003329 amyloid beta deposits 
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003447 reduced tumor growth/size "less than expected development of tumorous growth when compared to controls" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator, J:65383]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0003545 increased alcohol consumption "greater than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0003546 decreased alcohol consumption "less than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Kiss1rtm1Gstn/Kiss1rtm1Gstn
Genetic Background: involves: 129P2/OlaHsd

 MP:0003691 abnormal microglial cell function "anomalous activity of the small neuroglial cells, possibly of mesodermal origin, which may become phagocytic, in areas of neural damage or inflammation" [hdene:Howard Dene , Mouse Genome Informatics Curator]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc,Tg(APPSWE)2576Kha/0
Genetic Background: involves: 129S4/SvJae * C57BL/6 * SJL

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd

Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Ccr2tm1Ifc/Ccr2+
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0003884 decreased macrophage count "fewer than the normal numbers of macrophages" [acv:Alicia Valenzuela, Genetic Resources Curator]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

Allelic Composition: Ccr2tm1.1Mpa/Ccr2tm1.1Mpa
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Ccr2tm1Mpa/Ccr2tm1Mpa,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0003887 increased hepatocyte apoptosis "increase in the number of hepatocytes undergoing programmed cell death" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0003888 liver hemorrhage "bleeding within the liver" [anna:Anna Anagnostopoulos, Mouse Genome Informatics Curator]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0004042 decreased susceptibility to kidney reperfusion injury "a diminished likelihood or extent of damage to the kidney when the blood supply is restored after a period of ischemia" [brs:Beverly Richards-Smith, Mouse Genome Informatics Curator]
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Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0004800 decreased susceptibility to experimental autoimmune encephalomyelitis "reduced likelihood that an organism will develop disease symptoms similar to human multiple sclerosis upon induction with antigens to Myelin Basic Protein (MBP), Proteolipid Protein (PLP), and/or Myelin Oligodendrocyte glycoprotein (MOG)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccr2tm2.1Ifc/Ccr2tm2.1Ifc,Cx3cr1tm1Litt/Cx3cr1+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Allelic Composition: Ccr2tm2.1Ifc/Ccr2tm2.1Ifc,Cx3cr1tm1Litt/Cx3cr1tm1Litt
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/N

 MP:0004883 abnormal blood vessel healing "anomaly in the repair process of blood vessels after injury" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr2tm1Ifc/Ccr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0004893 decreased adiponectin level "reduced concentration of a protein hormone that regulates glucose homeostasis and metabolism of lipids; it is normally produced by adipose tissue" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

 MP:0004983 abnormal osteoclast cell number "deviation from the average number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0004985 decreased osteoclast cell number "reduced number of the bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Timp2tm1Pds/Timp2tm1Pds
Genetic Background: B6.129S4-Timp2tm1Pds

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Nfkbiatm1Fey/Nfkbiatm1Fey
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005023 abnormal wound healing "aberrant process of repair of trauma to any tissues of the body, especially that caused by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr2tm1.1Mpa/Ccr2tm1.1Mpa
Genetic Background: involves: BALB/cJ * C57BL/6

Allelic Composition: Ccr2tm1Mpa/Ccr2tm1Mpa,Lyz2tm1(cre)Ifo/Lyz2+
Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

 MP:0005036 diarrhea "abnormally frequent discharge of semi-solid or fluid fecal matter from the bowel" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Nfkbiatm1Fey/Nfkbiatm1Fey
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0005087 reduced acute inflammation "less than the expected early reaction of the microcirculation, characterized by movement of fluid and leukocytes from the blood into extravascular tissues; initiated by injury, infection, or local immune response " [Pathology:ISBN 0-397-51047-0, J:74478]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005098 abnormal choroid morphology "anomalous structure of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0005178 increased total circulating cholesterol level "greater than the normal concentration in the blood of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

 MP:0005201 abnormal retinal pigment epithelium morphology "anomaly in the epithelial layer of the retina composed of cells containing pigment granules " [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0005239 abnormal Bruch membrane morphology "anomalous structure of the transparent, nearly structureless inner layer of the choroid in contact with the pigmented layer of the retina" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0005264 glomerulosclerosis "hyaline deposits or scarring within the renal glomeruli, often occurring with renal arteriosclerosis or diabetes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

 MP:0005278 abnormal cholesterol homeostasis "anomaly in the state of equilibrium in the body of these most abundant steroids in animal tissues, and precursors to steroid hormones and bile salts; also components of plasma membranes" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, J:71350]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005325 abnormal glomerulus "anomalous structure of the capillary loops of the kidney that normally function as a filtration unit" [J:57971, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

Allelic Composition: Ccr2tm1.1(CCR2)Rodb/Ccr2tm1.1(CCR2)Rodb
Genetic Background: involves: C57BL/6

 MP:0005326 abnormal podocytes "anomalous structure of the foot processes of the epithelial cells of the glomerulus" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, J:57971]
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Allelic Composition: Ccr2tm1.1(CCR2)Rodb/Ccr2tm1.1(CCR2)Rodb
Genetic Background: involves: C57BL/6

 MP:0005341 decreased susceptibility to atherosclerosis "less likely than the norm to develop thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr2tm1Ifc/Ccr2+
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr2tm1Ifc/Ccr2tm1Ifc,Cx3cl1tm1Lira/Cx3cl1tm1Lira
Genetic Background: B6.Cg-Apoetm1Unc Cx3cl1tm1Lira Ccr2tm1Ifc

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: B6.Cg-Apoetm1Unc Ccr2tm1Ifc

 MP:0005362 abnormal Langerhans cell physiology "atypical or failure of normal function of the phagocytic dendritic cells principally found in the epidemis" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005546 choroidal neovascularization "new, abnormal, vessel development of the thin, highly vascularized membrane covering most of the posterior of the eye between the retina and the sclera" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0005554 decreased circulating creatinine level "less than the normal blood concentration of this product of creatine catabolism; abnormal levels indicative of renal dysfunction" [Stedman s Medical Dictionary:ISBN 0-683-40008-8, RGD:Rat Genome Database submission]
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Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * BALB/c

 MP:0005597 decreased susceptibility to type I hypersensitivity reaction "less likelihood or resistance to developing a response manifested by localized or generalized reaction that occurs immediately (minutes) after exposure to an antigen to which the person/animal was previously sensitized; it is IgE-mediated, and mast cell activation and degranulation are hallmarks" [Pathology:ISBN 0-397-51047-0, J:68588, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0005669 increased circulating leptin level "greater than the normal blood concentration of the peptide hormone secreted by white adipocytes and believed to regulate food intake and energy balance" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, J:34751]
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Allelic Composition: Ay/a,Apoetm1Unc/Apoetm1Unc,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl

 MP:0006187 retinal deposits "abnormal accumulation of material on the retina" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0006238 abnormal choriocapillaris morphology "malformation of the capillaries forming the inner vascular layer of the choroid of the eye" [ncbi:Matthew Mailman, NCBI request, smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0006315 abnormal kidney protein excretion "anomaly in the amount of protein eliminated by the kidneys" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ropn1Gt(OST21705)Lex/Ropn1Gt(OST21705)Lex,Ropn1lGt(OST20298)Lex/Ropn1lGt(OST20298)Lex
Genetic Background: involves: 129S5/SvEvBrd

Allelic Composition: Ccr2tm1.1(CCR2)Rodb/Ccr2tm1.1(CCR2)Rodb
Genetic Background: involves: C57BL/6

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkbiatm1Fey/Nfkbiatm1Fey
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008078 increased CD8-positive T cell number "greater number of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkbiatm1Fey/Nfkbiatm1Fey
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008126 increased dendritic cell number "greater number of a cells of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation" [ISBN:0781735149, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0008396 abnormal osteoclast differentiation "atypical production of or inability to produce bone resorpting cells that remove bone tissue by degrading the mineralized matrix" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0008450 retinal photoreceptor degeneration "a retrogressive impairment of function or destruction of a cell specialized to detect and transduce light, including rods and cones of the retina" [MESH:A08.663.650.650, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0008518 retinal outer nuclear layer degeneration "a retrogressive impairment or destruction of the retinal layer that contains the nuclei and cell bodies of rods and cones" [MGI:monikat "Monika Tomczuk, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0008537 increased susceptibility to induced colitis "increased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Nfkbiatm1Fey/Nfkbiatm1Fey
Genetic Background: involves: 129S6/SvEvTac * C57BL/6

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: B6.Cg-Apoetm1Unc Ccr2tm1Ifc

 MP:0008560 increased tumor necrosis factor secretion "increase in the production or release of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MESH:D12.644.276.374.500.800]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008722 abnormal chemokine secretion "anomaly in the production or cellular release of any of the class of pro-inflammatory cytokines that attract and activate leukocytes" [MESH:D12.644.276.374.200]
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Allelic Composition: Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: involves: 129P2/OlaHsd

 MP:0008750 abnormal interferon level "deviation from the normal levels of proteins secreted by vertebrate cells in response to a wide variety of inducers; they confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions" [MESH:D12.644.276.374.440]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

 MP:0008813 decreased common myeloid progenitor cell number "reduced number of progenitor cells committed to myeloid lineage, including the megakaryocyte and erythroid lineages" [CL:0000049, MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0008842 lipofuscinosis "storage in organs of brownish fatty pigment resulting from the breakdown and absorption of damaged blood cells" [MGI:llw2 "Linda Washburn, Mouse Genome Informatics Curator"]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

Allelic Composition: Ccr2tm1.1(CCR2)Rodb/Ccr2tm1.1(CCR2)Rodb
Genetic Background: involves: C57BL/6

 MP:0009335 decreased splenocyte proliferation "reduction in the expansion rate of a splenocyte cell population by cell division" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0009347 increased cancellous bone thickness "thicker than normal bone with a lattice-like or spongy structure" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0009791 increased susceptibility to viral infection induced morbidity/mortality "increased likelihood that an organism will display the expected moribund state caused by a viral invasion or from components of or toxins produced by a virus" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
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Allelic Composition: Kiss1rtm1Gstn/Kiss1rtm1Gstn
Genetic Background: involves: 129P2/OlaHsd

 MP:0009878 decreased susceptibility to bone fracture "reduced probability that injury or disease will result in damaged or broken bones" [MGI:hdene "Howard Dene, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0010119 abnormal bone mineral density "anomaly in the amount of mineral per square centimeter of bone (usually g/cm2), used as a measure of structural strength and screen for osteoporosis; bone mineral density is the ratio of bone mineral content to bone size" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0010740 abnormal dendritic cell chemotaxis "anomaly in the movement of a dendritic cell in response to an external stimulus" [GO:0002407]
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Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0010760 abnormal macrophage chemotaxis "anomaly in the movement of a macrophage guided by a specific chemical concentration gradient" [GO:0048246]
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Allelic Composition: Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: involves: 129S4/SvJae * C57BL/6

 MP:0010867 abnormal bone trabecula morphology "any structural anomaly of the network of intersecting plates and spicules in cancellous bone which form a meshwork of intercommunicating spaces filled with blood vessels and marrow; in mature bone, the trabeculae are aligned in parallel with the lines of major compressive or tensile force" [http://www.dorlands.com/ "Dorland s Illustrated Medical Dictionary, 31st edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0010878 increased trabecular bone volume "increase in the amount of space occupied by trabecular bone tissue in the skeleton" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Apoa1tm1Unc/Apoa1tm1Unc
Genetic Background: B6.129P2-Apoa1tm1Unc/J

 MP:0011346 renal tubule atrophy "acquired diminution of the size of the loops of Henle, the proximal convoluted tubule or the distal convoluted tubule associated with wasting as from death and reabsorbtion of cells, diminished cellular proliferation, decreased cellular volume, pressure, ischemia, malnutrition, reduced function or malfunction, or hormonal changes" [MGI:anna]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

 MP:0011353 expanded mesangial matrix "increase in the amount of mesangial matrix present in the basement membrane surrounding the glomerular capillaries that also contain the intraglomerular mesangial cells" [MGI:csmith]
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Allelic Composition: Ccr2tm1Blck/Ccr2tm1Blck,Faslpr/Faslpr
Genetic Background: MRL.Cg-Ccr2tm1Blck Faslpr

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Tnfrsf13btm1Rjb/Tnfrsf13btm1Rjb
Genetic Background: involves: 129X1/SvJ

 MP:0013648 increased CD11b-high dendritic cell number "increase in the number of dendritic cells expressing high levels of CD11b which usually depend on Irf4 for their development" [MGI:Saran, PMID:23516985]
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Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0013649 decreased CD11b-high dendritic cell number "reduction in the number of dendritic cells expressing high levels of CD11b which usually depend on Irf4 for their development" [MGI:Saran, PMID:23516985]
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Allelic Composition: Col1a1tm5(CAG-FGFR2_iIIIb*W290C)Kkw/Col1a1+,Trp53tm1Brn/Trp53tm1Brn
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * BALB/c * C57BL/6

 MP:0020332 impaired leukocyte tethering or rolling "reduced ability or inability in the transient adhesive interactions between leukocytes and endothelial cells lining blood vessels mediated primarily by selectins and which are typically the first step in cellular extravasation" [GO:0050901, ORCID: orcid.org/0000-0003-4606-0597]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic Background: B6.Cg-Apoetm1Unc Ccr2tm1Ifc

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000046354 Defb14 / Q7TNV9 / Beta-defensin 14 / P81534* / DEFB103B* / DEFB103A* / defensin beta 103A* / defensin beta 103B*  / complex / reaction






 

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