ENSMUSG00000079227


Mus musculus

Features
Gene ID: ENSMUSG00000079227
  
Biological name :Ccr5
  
Synonyms : C-C chemokine receptor type 5 / Ccr5 / P51682
  
Possible biological names infered from orthology : C-C motif chemokine receptor 5 (gene/pseudogene) / P51681
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F4
Gene start: 124121543
Gene end: 124147699
  
Corresponding Affymetrix probe sets: 10590635 (MoGene1.0st)   10598013 (MoGene1.0st)   1422259_a_at (Mouse Genome 430 2.0 Array)   1422260_x_at (Mouse Genome 430 2.0 Array)   1424727_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000107069
Ensembl peptide - ENSMUSP00000149719
Ensembl peptide - ENSMUSP00000129848
Ensembl peptide - ENSMUSP00000127328
NCBI entrez gene - 12774     See in Manteia.
MGI - MGI:107182
RefSeq - NM_009917
RefSeq Peptide - NP_034047
swissprot - E9Q351
swissprot - A0A1L1SS26
swissprot - E9Q3E5
swissprot - P51682
Ensembl - ENSMUSG00000079227
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccr11.1ENSDARG00000070755Danio rerio
 ccr2ENSDARG00000105363Danio rerio
 ccr2ENSDARG00000079829Danio rerio
 CCR2ENSGALG00000011733Gallus gallus
 CCR5ENSGALG00000037077Gallus gallus
 CCR5ENSG00000160791Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccr2 / P51683 / C-C chemokine receptor type 2 / P41597* / C-C motif chemokine receptor 2*ENSMUSG0000004910377
Ccr1 / P51675 / C-C chemokine receptor type 1 / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000002580453
Ccr3 / P51678 / Probable C-C chemokine receptor type 3 / P51677* / C-C motif chemokine receptor 3*ENSMUSG0000003544853
Ccr4 / P51680 / C-C chemokine receptor type 4 / P51679* / C-C motif chemokine receptor 4*ENSMUSG0000004789849
Ccr1l1 / P51676 / C-C chemokine receptor 1-like protein 1 / CCR1* / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000006403944
Cx3cr1 / Q9Z0D9 / CX3C chemokine receptor 1 / P49238* / C-X3-C motif chemokine receptor 1*ENSMUSG0000005233641
Ccr8 / P56484 / C-C chemokine receptor type 8 / P51685* / C-C motif chemokine receptor 8*ENSMUSG0000004226240
Ackr2 / O08707 / atypical chemokine receptor 2 / O00590*ENSMUSG0000004453434
Ccr9 / Q9WUT7 / C-C chemokine receptor type 9 / P51686* / C-C motif chemokine receptor 9*ENSMUSG0000002953034
Ccr7 / P47774 / C-C chemokine receptor type 7 / P32248* / C-C motif chemokine receptor 7*ENSMUSG0000003794433
Cxcr3 / O88410 / C-X-C chemokine receptor type 3 / P49682* / C-X-C motif chemokine receptor 3*ENSMUSG0000005023232
Ccr6 / O54689 / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA. / P51684* / C-C motif chemokine receptor 6*ENSMUSG0000004089932
Cxcr2 / P35343 / C-X-C chemokine receptor type 2 / P25025* / C-X-C motif chemokine receptor 2*ENSMUSG0000002618031
Cxcr1 / Q810W6 / C-X-C chemokine receptor type 1 / P25024* / C-X-C motif chemokine receptor 1*ENSMUSG0000004848031
Xcr1 / chemokine (C motif) receptor 1 / P46094* / X-C motif chemokine receptor 1*ENSMUSG0000006050930
Ackr4 / Q924I3 / atypical chemokine receptor 4 / Q9NPB9*ENSMUSG0000007935529
Cxcr5 / Q04683 / C-X-C chemokine receptor type 5 / P32302* / C-X-C motif chemokine receptor 5*ENSMUSG0000004788029
Ccr10 / Q9JL21 / C-C chemokine receptor type 10 / P46092* / C-C motif chemokine receptor 10*ENSMUSG0000004405229
Cxcr4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073* / C-X-C motif chemokine receptor 4*ENSMUSG0000004538228
Cxcr6 / Q9EQ16 / C-X-C chemokine receptor type 6 / O00574* / C-X-C motif chemokine receptor 6*ENSMUSG0000004852128


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR002240  CC chemokine receptor 5
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006952 defense response IMP
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum IEA
 biological_processGO:0019722 calcium-mediated signaling IEA
 biological_processGO:0023052 signaling IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 biological_processGO:0070723 response to cholesterol IEA
 biological_processGO:0071222 cellular response to lipopolysaccharide IEA
 biological_processGO:2000110 negative regulation of macrophage apoptotic process IDA
 cellular_componentGO:0005768 endosome IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IEA
 cellular_componentGO:0009986 cell surface IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0003779 actin binding IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity IEA
 molecular_functionGO:0016493 C-C chemokine receptor activity ISO
 molecular_functionGO:0019957 C-C chemokine binding IEA
 molecular_functionGO:0071791 chemokine (C-C motif) ligand 5 binding IEA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000343 altered response to myocardial infarction "change in the physiological response to necrosis of the cardiac tissue, often resulting from the sudden insufficiency of arterial or venous blood supply due to emboli, thrombi or mechanical factors" [MeSH:National Library of Medicine - Medical Subject Headings, 2003, Stedman s Medical Dictionary, 27th edition:ISBN 0-683-40008-8]
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Allelic Composition: Kiss1rtm1Gstn/Kiss1rtm1Gstn
Genetic Background: involves: 129P2/OlaHsd

 MP:0001273 decreased metastatic potential 
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Allelic Composition: Ccr5tm1Kuz/Ccr5tm1Kuz,Cxcr4tm1Qma/Cxcr4tm1Qma
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0001392 abnormal locomotor activity "altered ability or inability to move from place to place" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0001544 abnormal cardiovascular system physiology "anomalous function of the blood, blood vessels, and/or the heart" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gabra1tm1.1Geh/Gabra1tm1.1Mjga
Genetic Background: B6J.Cg-Gabra1tm1.1Geh Gabra1tm1.1Mjga

 MP:0001876 decreased inflammatory response "less than expected response to injury, infection, or insult" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gabra1tm1.1Geh/Gabra1tm1.1Mjga
Genetic Background: B6J.Cg-Gabra1tm1.1Geh Gabra1tm1.1Mjga

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Allelic Composition: Ccr5tm1Kuz/Ccr5tm1Kuz,Cxcr4tm1Qma/Cxcr4tm1Qma
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0002412 increased susceptibility to bacterial infection "greater likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tyrc-19J/Tyrc-19J
Genetic Background: 129P1/ReJ-Tyrc-19J

 MP:0002432 abnormal CD4+ T cell morphology/development "anomalous structure, differentiation, or number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0002442 abnormal leukocyte physiology "abnormal function of any of the white blood cells (basophils, eosinophils, neutrophils, lymphocytes, or monocytes) " [Stedman s Medical Dictionary:ISBN 0-683-40008-8, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: involves: 129 * C57BL/6

 MP:0002805 abnormal conditioned taste aversion behavior "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0003009 abnormal cytokine secretion "impairment or increase of the cellular release of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7, smb:Susan M. Bello , Mouse Genome Informatics Curator]
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Allelic Composition: Tyrc-19J/Tyrc-19J
Genetic Background: 129P1/ReJ-Tyrc-19J

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Kuz/Ccr5tm1Kuz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Blck/Ccr5tm1Blck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0003326 liver failure "cessation of function of this bile-secreting exocrine gland, which is important for detoxification; for fat, carbohydrate, and protein metabolism; and for glycogen storage " [MeSH:National Library of Medicine - Medical Subject Headings , 2003, ncbi:Matthew Mailman, NCBI request]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0003545 increased alcohol consumption "greater than normal consumption of alcohol" [RGD:Rat Genome Database submission]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Kiss1rtm1Gstn/Kiss1rtm1Gstn
Genetic Background: involves: 129P2/OlaHsd

 MP:0003633 abnormal nervous system physiology 
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

Allelic Composition: Ccr5tm1Kuz/Ccr5tm1Kuz,Cxcr4tm1Qma/Cxcr4tm1Qma
Genetic Background: involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

 MP:0003690 abnormal glial cell physiology "anomalous function of non-neuronal cells of the central nervous system that form the myelin insulation of nervous pathways, guide neuronal migration during development, and exchange metabolites with neurons" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0003799 impaired macrophage migration "defect in the ability of macrophages to move up a chemotactic gradient" [smb:Susan M Bello, Mouse Genome Informatics Curator]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0003945 abnormal lymphocyte physiology "abnormal function of any of the white blood cells that includes B cells, T cells, and NK cells " [monikat:Monika Tomczuk, Mouse Genome Informatics Curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Kuz/Ccr5tm1Kuz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Blck/Ccr5tm1Blck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0004751 increased length of allograft survival "compared to controls, a greater length of time that transplanted tissue, in which the donor and recipient are genetically similar (same species) but not genetically identical, retains function and/or remains alive" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Kiss1rtm1Gstn/Kiss1rtm1Gstn
Genetic Background: involves: 129P2/OlaHsd

 MP:0005010 abnormal CD8+ T cell morphology/development "anomalous structure, formation, or numbers of the regulatory subset of T lymphocytes that are involved in MHC class I restricted interactions" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0005018 decreased T cell number "fewer than normal T cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Kmt2atm1.1Mlc/Kmt2atm1.1Mlc
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Blck/Ccr5tm1Blck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Il23atm1Dnax/Il23atm1Dnax
Genetic Background: involves: 129 * C57BL/6

 MP:0005166 decreased susceptiblity to injury "less than the normal reaction to trauma, especially that by physical means" [Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Gabra1tm1.1Geh/Gabra1tm1.1Mjga
Genetic Background: B6J.Cg-Gabra1tm1.1Geh Gabra1tm1.1Mjga

 MP:0005338 atherosclerotic lesions "thickening and loss of elasticity of arterial walls, involving lipid deposition and thickening of intimal layers within arteries" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Kuz/Ccr5tm1Kuz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Blck/Ccr5tm1Blck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005399 increased susceptibility to fungal infection "greater likelihood that an organism will develop ill effects from infection by a yeast or mold, or from components of, or toxins produced by, these organisms" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0005406 abnormal heart size "change from the norm in the physical magnitude of the cardiac muscle or any of its component structures" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Gabra1tm1.1Geh/Gabra1tm1.1Mjga
Genetic Background: B6J.Cg-Gabra1tm1.1Geh Gabra1tm1.1Mjga

 MP:0005542 corneal vascularization "formation of blood vessels in the cornea, which normally lacks vessels" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Stedman s Medical Dictionary:ISBN 0-683-40008-8]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0005592 abnormal vascular smooth muscle morphology "structural anomaly of the nonstriated, involuntary muscle tissue of the blood vessels" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Kuz/Ccr5tm1Kuz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0005617 increased susceptibility to type IV hypersensitivity reaction "greater likelihood of developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Tyrc-19J/Tyrc-19J
Genetic Background: 129P1/ReJ-Tyrc-19J

 MP:0008039 increased NK T cell number "greater number of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0008042 abnormal NK T cell physiology "any functional anomaly of the distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments" [GO:0001865]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0008045 decreased NK cell number "reduction in the number of non-T, non-B lymphocytes, having a granular morphology and which are important in innate immunity to viruses and other intracellular pathogens; in addition, these cells can kill certain tumor cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease"]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0008114 abnormal Kupffer cell morphology "any structural anomaly of the phagocytic macrophages residing on the luminal surface of the hepatic sinusoids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0008248 abnormal mononuclear phagocyte morphology "any structural anomaly of a vertebrate phagocyte with a single nucleus" [CL:0000113]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Kuz/Ccr5tm1Kuz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Blck/Ccr5tm1Blck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0008499 increased IgG1 level "greater than normal immunoglobulin class G1 level" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tyrc-19J/Tyrc-19J
Genetic Background: 129P1/ReJ-Tyrc-19J

 MP:0008539 decreased susceptibility to induced colitis "decreased severity or induction threshold of colitis upon treatment of an organism with intestinal inflammation agents such as dextran sodium sulfate (DSS)" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0008566 increased interferon-gamma secretion "increase in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Tyrc-19J/Tyrc-19J
Genetic Background: 129P1/ReJ-Tyrc-19J

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Kuz/Ccr5tm1Kuz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Blck/Ccr5tm1Blck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008658 decreased interleukin-1 beta secretion "reduction in the production or release of an interleukin-1 subtype that is synthesized as an inactive membrane-bound pro-protein on monocytes, macrophages and other cells; proteolytic processing of the precursor form by caspase 1 results in release of the active form of interleukin-1beta from the membrane" [MESH:D12.644.276.374.465.501.600]
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Allelic Composition: Tyrc-19J/Tyrc-19J
Genetic Background: 129P1/ReJ-Tyrc-19J

 MP:0008660 increased interleukin-10 secretion "increase in the production or release of a cytokine produced by a variety of cell types, including T-cells, monocytes, dendritic cells and epithelial cells that exerts a variety of effects on immunoregulation and inflammation" [MESH:D12.644.276.374.465.510]
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Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Kuz/Ccr5tm1Kuz
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

Allelic Composition: Apoetm1Unc/Apoetm1Unc,Ccr5tm1Blck/Ccr5tm1Blck
Genetic Background: involves: 129P2/OlaHsd * C57BL/6

 MP:0008699 increased interleukin-4 secretion "increase in the production or release of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
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Allelic Composition: Tyrc-19J/Tyrc-19J
Genetic Background: 129P1/ReJ-Tyrc-19J

 MP:0008706 decreased interleukin-6 secretion "reduction in the production or release of a cytokine that stimulates the growth and differentiation of B-cells and is also a growth factor for hybridomas and plasmacytomas, and is produced by many different cells including T-cells, monocytes and fibroblasts" [MESH:D12.644.276.374.465.506]
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Allelic Composition: Tyrc-19J/Tyrc-19J
Genetic Background: 129P1/ReJ-Tyrc-19J

 MP:0008713 abnormal cytokine level "deviation from the normal levels of any of the non-antibody proteins made by inflammatory leukocytes and some non-leukocytic cells that affect the behavior of other cells" [ISBN:0-8153-1691-7 "Immunobiology, The Immune System in Health and Disease", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0008734 decreased susceptibility to endotoxin shock "less than the expected early reaction of the microcirculation to endotoxins such as LPS, characterized by movement of fluid and leukocytes from the blood into extravascular tissues and often resulting in death" [MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Tyrc-19J/Tyrc-19J
Genetic Background: 129P1/ReJ-Tyrc-19J

 MP:0008873 increased sensitivity to xenobiotics "decrease in the dose or concentration of a foreign compound required to induce a specific level of response" [MGI:smb "Susan M. Bello, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabra1tm1.1Geh/Gabra1tm1.1Mjga
Genetic Background: B6J.Cg-Gabra1tm1.1Geh Gabra1tm1.1Mjga

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0008990 abnormal Ito cell morphology "any structural anomaly of the fat-storing cells that line the hepatic sinusoids" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition"]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0009858 abnormal cellular extravasation "any anomaly in the migration of leukocytes from the blood vessels into the surrounding tissue" [GO:0045123]
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Allelic Composition: Kiss1rtm1Gstn/Kiss1rtm1Gstn
Genetic Background: involves: 129P2/OlaHsd

 MP:0010080 abnormal hepatocyte physiology "any functional anomaly of the main structural specialized epithelial cells which normally organize into interconnected plates called lobules" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

 MP:0010759 decreased right ventricle systolic pressure "decrease in the pressure in the right ventricle as the heart contracts and pumps blood into the arteries" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Gabra1tm1.1Geh/Gabra1tm1.1Mjga
Genetic Background: B6J.Cg-Gabra1tm1.1Geh Gabra1tm1.1Mjga

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
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Allelic Composition: Ccl2tm1Rol/Ccl2tm1Rol,Ccr2tm1Mae/Ccr2tm1Mae
Genetic Background: B6.129-Ccr2tm1Mae Ccl2tm1Rol

 MP:0020449 decreased microglial cell activation "decrease in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]
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Allelic Composition: Itgb8tm1Lfr/Itgb8tm2Lfr,Tg(Tek-cre)1Rwng/0
Genetic Background: involves: 129/Sv * 129X1/SvJ * C57BL/6 * FVB/N * SJL

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000018930 Ccl4 / P14097 / C-C motif chemokine 4 / Q8NHW4* / CCL4L2* / P13236* / C-C motif chemokine ligand 4* / C-C motif chemokine ligand 4 like 2*  / complex
 ENSMUSG00000035042 Ccl5 / P30882 / C-C motif chemokine 5 / P13501* / C-C motif chemokine ligand 5*  / complex / reaction






 

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