ENSMUSG00000047880


Mus musculus

Features
Gene ID: ENSMUSG00000047880
  
Biological name :Cxcr5
  
Synonyms : C-X-C chemokine receptor type 5 / Cxcr5 / Q04683
  
Possible biological names infered from orthology : C-X-C motif chemokine receptor 5 / P32302
  
Species: Mus musculus
  
Chr. number: 9
Strand: -1
Band: A5.2
Gene start: 44511787
Gene end: 44561877
  
Corresponding Affymetrix probe sets: 10592888 (MoGene1.0st)   1422003_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000149400
Ensembl peptide - ENSMUSP00000149508
Ensembl peptide - ENSMUSP00000050444
Ensembl peptide - ENSMUSP00000137518
NCBI entrez gene - 12145     See in Manteia.
MGI - MGI:103567
RefSeq - NM_007551
RefSeq Peptide - NP_031577
swissprot - A0A1L1SRC9
swissprot - Q04683
Ensembl - ENSMUSG00000047880
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 cxcr5ENSDARG00000010514Danio rerio
 CXCR5ENSGALG00000007675Gallus gallus
 CXCR5ENSG00000160683Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Cxcr3 / O88410 / C-X-C chemokine receptor type 3 / P49682* / C-X-C motif chemokine receptor 3*ENSMUSG0000005023235
Ccr7 / P47774 / C-C chemokine receptor type 7 / P32248* / C-C motif chemokine receptor 7*ENSMUSG0000003794432
Ccr10 / Q9JL21 / C-C chemokine receptor type 10 / P46092* / C-C motif chemokine receptor 10*ENSMUSG0000004405232
Cxcr2 / P35343 / C-X-C chemokine receptor type 2 / P25025* / C-X-C motif chemokine receptor 2*ENSMUSG0000002618031
Cxcr1 / Q810W6 / C-X-C chemokine receptor type 1 / P25024* / C-X-C motif chemokine receptor 1*ENSMUSG0000004848030
Ccr4 / P51680 / C-C chemokine receptor type 4 / P51679* / C-C motif chemokine receptor 4*ENSMUSG0000004789829
Ccr9 / Q9WUT7 / C-C chemokine receptor type 9 / P51686* / C-C motif chemokine receptor 9*ENSMUSG0000002953029
Cxcr4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073* / C-X-C motif chemokine receptor 4*ENSMUSG0000004538229
Cx3cr1 / Q9Z0D9 / CX3C chemokine receptor 1 / P49238* / C-X3-C motif chemokine receptor 1*ENSMUSG0000005233628
Ccr6 / O54689 / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA. / P51684* / C-C motif chemokine receptor 6*ENSMUSG0000004089928
Ackr2 / O08707 / atypical chemokine receptor 2 / O00590*ENSMUSG0000004453428
Ccr1 / P51675 / C-C chemokine receptor type 1 / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000002580427
Ackr4 / Q924I3 / atypical chemokine receptor 4 / Q9NPB9*ENSMUSG0000007935527
Ccr5 / P51682 / C-C chemokine receptor type 5 / P51681* / C-C motif chemokine receptor 5 (gene/pseudogene)*ENSMUSG0000007922727
Cxcr6 / Q9EQ16 / C-X-C chemokine receptor type 6 / O00574* / C-X-C motif chemokine receptor 6*ENSMUSG0000004852127
Ccr2 / P51683 / C-C chemokine receptor type 2 / P41597* / C-C motif chemokine receptor 2*ENSMUSG0000004910327
Ccr8 / P56484 / C-C chemokine receptor type 8 / P51685* / C-C motif chemokine receptor 8*ENSMUSG0000004226226
Ccr3 / P51678 / Probable C-C chemokine receptor type 3 / P51677* / C-C motif chemokine receptor 3*ENSMUSG0000003544826
Xcr1 / chemokine (C motif) receptor 1 / P46094* / X-C motif chemokine receptor 1*ENSMUSG0000006050925
Ccr1l1 / P51676 / C-C chemokine receptor 1-like protein 1 / CCR1* / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000006403925


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR001053  CXC chemokine receptor 5
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0030595 leukocyte chemotaxis IDA
 biological_processGO:0032467 positive regulation of cytokinesis ISO
 biological_processGO:0042113 B cell activation IEA
 biological_processGO:0048535 lymph node development IMP
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0009897 external side of plasma membrane IDA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0016494 C-X-C chemokine receptor activity IEA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0002169 no phenotype detected "normal, viable and fertile appearance and behavior; indistinguishable from controls" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
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Allelic Composition: Ddx60tm1b(EUCOMM)Wtsi/Ddx60tm1b(EUCOMM)Wtsi,Mavstm1Tsse/Mavstm1Tsse
Genetic Background: involves: 129 * C57BL/6N

 MP:0002831 absent Peyer s patches "lymphoid tissue missing from the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0005014 increased B cell number "greater than normal B cell numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0005363 decreased susceptibility to prion infection "reduced likelihood that an organism will develop ill effects from the small proteinaceous infectious particles which are resistant to inactivation by procedures that modify nucleic acids and which contain an abnormal isoform of a cellular protein that is a major and necessary component" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, MeSH:National Library of Medicine - Medical Subject Headings , 2003]
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Allelic Composition: Ddx60tm1b(EUCOMM)Wtsi/Ddx60tm1b(EUCOMM)Wtsi,Mavstm1Tsse/Mavstm1Tsse
Genetic Background: involves: 129 * C57BL/6N

Allelic Composition: Cxcr5tm1.1Namt/Cxcr5tm1.1Namt,Tg(Itgax-cre)1-1Reiz/0,Tg(Prnp)a20Cwe/0
Genetic Background: involves: C57BL/6 * C57BL/6J * CBA

 MP:0008024 absent lymph nodes "absence of the oval or bean shaped bodies located along the lymphatic system that consist of densely packed lymphocytes, lymph fluid and connective tissue; these are the sites where acquired immune responses are launched" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0008200 decreased follicular dendritic cell number "reduced number of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200]
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Allelic Composition: Ddx60tm1b(EUCOMM)Wtsi/Ddx60tm1b(EUCOMM)Wtsi,Mavstm1Tsse/Mavstm1Tsse
Genetic Background: involves: 129 * C57BL/6N

 MP:0008201 absent follicular dendritic cells "absence of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0008471 abnormal spleen primary B follicle morphology "any structural anomaly of the nodules of small undifferentiated B lymphocytes and follicular dendritic cells located in the spleen white pulp" [PMID:17495967]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0008472 abnormal spleen secondary B follicle morphology "any strucutral anomaly of the nodules of antigen-activated, differentiating B cells, follicular dendritic cells, antigen-presenting T cells and macrophages in the spleen white pulp" [PMID:17495967]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0008474 absent spleen germinal center "absence of the area of the spleen secondary B follicle where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0009622 absent inguinal lymph nodes "absence of the lymph nodes normally located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0009628 absent brachial lymph nodes "absence of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0009630 absent axillary lymph nodes "absence of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0009633 absent cervical lymph nodes "absence of the lymph nodes normally found near the neck and shoulders" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Zic3Bn/Zic3Bn
Genetic Background: BNT/LeJ

 MP:0010740 abnormal dendritic cell chemotaxis "anomaly in the movement of a dendritic cell in response to an external stimulus" [GO:0002407]
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Allelic Composition: Ddx60tm1b(EUCOMM)Wtsi/Ddx60tm1b(EUCOMM)Wtsi,Mavstm1Tsse/Mavstm1Tsse
Genetic Background: involves: 129 * C57BL/6N

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000023078 Cxcl13 / O55038 / C-X-C motif chemokine 13 / O43927* / C-X-C motif chemokine ligand 13*  / reaction / complex






 

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