ENSMUSG00000023078


Mus musculus

Features
Gene ID: ENSMUSG00000023078
  
Biological name :Cxcl13
  
Synonyms : Cxcl13 / C-X-C motif chemokine 13 / O55038
  
Possible biological names infered from orthology : C-X-C motif chemokine ligand 13 / O43927
  
Species: Mus musculus
  
Chr. number: 5
Strand: 1
Band: E3
Gene start: 95956951
Gene end: 95961068
  
Corresponding Affymetrix probe sets: 10523359 (MoGene1.0st)   1417851_at (Mouse Genome 430 2.0 Array)   1448859_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000023840
NCBI entrez gene - 55985     See in Manteia.
MGI - MGI:1888499
RefSeq - NM_018866
RefSeq Peptide - NP_061354
swissprot - O55038
swissprot - Q3U1E8
Ensembl - ENSMUSG00000023078
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 CXCL13ENSG00000156234Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
No match


Protein motifs (from Interpro)
Interpro ID Name
 IPR001089  CXC chemokine
 IPR001811  Chemokine interleukin-8-like domain
 IPR018048  CXC chemokine, conserved site
 IPR033899  CXC Chemokine domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0002518 lymphocyte chemotaxis across high endothelial venule IMP
 biological_processGO:0002690 positive regulation of leukocyte chemotaxis IBA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006952 defense response IEA
 biological_processGO:0006954 inflammatory response IBA
 biological_processGO:0006955 immune response IBA
 biological_processGO:0007166 cell surface receptor signaling pathway ISO
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration ISS
 biological_processGO:0007267 cell-cell signaling ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010820 positive regulation of T cell chemotaxis ISS
 biological_processGO:0032496 response to lipopolysaccharide IBA
 biological_processGO:0033625 positive regulation of integrin activation IDA
 biological_processGO:0033634 positive regulation of cell-cell adhesion mediated by integrin IDA
 biological_processGO:0035754 B cell chemotaxis IMP
 biological_processGO:0035768 endothelial cell chemotaxis to fibroblast growth factor ISO
 biological_processGO:0035769 B cell chemotaxis across high endothelial venule IDA
 biological_processGO:0042127 regulation of cell proliferation IBA
 biological_processGO:0042742 defense response to bacterium ISS
 biological_processGO:0048535 lymph node development IDA
 biological_processGO:0070098 chemokine-mediated signaling pathway NAS
 biological_processGO:0090630 activation of GTPase activity IDA
 biological_processGO:2000545 negative regulation of endothelial cell chemotaxis to fibroblast growth factor ISO
 cellular_componentGO:0005576 extracellular region ISS
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005623 cell IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008009 chemokine activity IDA
 molecular_functionGO:0008201 heparin binding ISS
 molecular_functionGO:0017134 fibroblast growth factor binding ISS
 molecular_functionGO:0031724 CXCR5 chemokine receptor binding IDA
 molecular_functionGO:0031735 CCR10 chemokine receptor binding ISS
 molecular_functionGO:0046982 protein heterodimerization activity ISS
 molecular_functionGO:0048018 receptor ligand activity ISS
 molecular_functionGO:0048248 CXCR3 chemokine receptor binding ISO


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000696 abnormal Peyer s patches morphology "anomalous structure, development, or cellular make-up of the lymphoid tissue located on the mucosa of the small intestine" [MeSH:National Library of Medicine - Medical Subject Headings , 2003, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0002219 decreased lymph node number "fewer than the normal number of lymph nodes " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0002362 abnormal spleen marginal zone morphology "anomalous structure of the area surrounding the marginal sinus and containing lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator, Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
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Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0002459 abnormal B cell physiology "abnormal function of B lymphocytes" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
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Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

Allelic Composition: Cxcl13tm1Cys/Cxcl13tm1Cys
Genetic Background: B6.129X1-Cxcl13tm1Cys

 MP:0003156 abnormal lymphocyte migration/homing "altered ability of blood lymphocytes to bind to high endothelial venules (HEV), tether and roll along the luminal aspects of HEV, and migrate into the lymph nodes" [acv:Alicia C. Valenzuela, Mouse Genome Informatics Curator, J:92231]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0003628 abnormal lymphocyte adhesion "anomaly in the number of or process by which lymphocytes adhere to the luminal aspects of high endothelial venules prior to transmigration out of the vessel" [smb:Susan M Bello, Mouse Genome Informatics Curator, J:95656]
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Allelic Composition: Cxcl13tm1Mmi/Cxcl13tm1Mmi
Genetic Background: involves: C57BL/6

 MP:0004977 increased B-1 B cell number "greater number of the subset of B cells found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: GckM1Btlr/Gck+
Genetic Background: C57BL/6J-GckM1Btlr

 MP:0008133 decreased Peyer s patch number "reduction in the number of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0008135 small Peyer s patches "reduced size of the protruding lymphoid tissue located on the mucosa of the small intestine that is composed of densly packed B cell follicles" [PMID:15841100]
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Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0008201 absent follicular dendritic cells "absence of cells with extensive dendritic processes found in the B cell areas (primary follicles and germinal centers) of lymphoid tissue; follicular dendritic cells have Fc receptors and C3b receptors, and hold antigen in the form of immune complexes on their surfaces for long periods and can present antigen to B cells during an immune response" [CL:0000442, MESH:A10.549.250.200, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0008470 abnormal spleen B cell follicle morphology "any structural anomaly of the area of the white pulp where the affinity maturation of B cells and the generation of memory B cells and plasma cells occur" [PMID:17495967]
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Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0008484 decreased spleen germinal center size "reduced size of spleen secondary B follicles where rapid B-cell proliferation, somatic hypermutation, and selection for antigen binding occurs" [PMID:17495967]
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Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0008522 abnormal lymph node germinal center "any strucutral anomaly of the area of the lymph node secondary follicle where B cells are stimulated by antigens and helper T cells are stimulated to generate memory cells" [MESH:A10.549.400.500, MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
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Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0009622 absent inguinal lymph nodes "absence of the lymph nodes normally located in the groin area" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0009628 absent brachial lymph nodes "absence of the lymph nodes located along the brachial vein that receive drainage from most of the free upper limb and send efferent vessels to the central axillary lymph nodes" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

 MP:0009630 absent axillary lymph nodes "absence of the lymph nodes located around the axillary vein that receive lymphatic drainage from the upper or forelimb, scapular region and pectoral region" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
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Allelic Composition: Adamts20bt/Adamts20bt
Genetic Background: DBA

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000047880 Cxcr5 / Q04683 / C-X-C chemokine receptor type 5 / P32302* / C-X-C motif chemokine receptor 5*  / reaction / complex






 

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