ENSMUSG00000035448


Mus musculus

Features
Gene ID: ENSMUSG00000035448
  
Biological name :Ccr3
  
Synonyms : Ccr3 / P51678 / Probable C-C chemokine receptor type 3
  
Possible biological names infered from orthology : C-C motif chemokine receptor 3 / P51677
  
Species: Mus musculus
  
Chr. number: 9
Strand: 1
Band: F4
Gene start: 124021972
Gene end: 124031689
  
Corresponding Affymetrix probe sets: 10590628 (MoGene1.0st)   1422957_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039107
NCBI entrez gene - 12771     See in Manteia.
MGI - MGI:104616
RefSeq - XM_017313120
RefSeq - NM_009914
RefSeq - XM_017313119
RefSeq Peptide - NP_034044
swissprot - P51678
Ensembl - ENSMUSG00000035448
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccr11.1ENSDARG00000070755Danio rerio
 ccr2ENSDARG00000105363Danio rerio
 ccr2ENSDARG00000079829Danio rerio
 CCR2ENSGALG00000011733Gallus gallus
 CCR5ENSGALG00000037077Gallus gallus
 CCR3ENSG00000183625Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccr1 / P51675 / C-C chemokine receptor type 1 / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000002580460
Ccr2 / P51683 / C-C chemokine receptor type 2 / P41597* / C-C motif chemokine receptor 2*ENSMUSG0000004910354
Ccr5 / P51682 / C-C chemokine receptor type 5 / P51681* / C-C motif chemokine receptor 5 (gene/pseudogene)*ENSMUSG0000007922752
Ccr1l1 / P51676 / C-C chemokine receptor 1-like protein 1 / CCR1* / P32246* / C-C motif chemokine receptor 1*ENSMUSG0000006403949
Ccr4 / P51680 / C-C chemokine receptor type 4 / P51679* / C-C motif chemokine receptor 4*ENSMUSG0000004789843
Cx3cr1 / Q9Z0D9 / CX3C chemokine receptor 1 / P49238* / C-X3-C motif chemokine receptor 1*ENSMUSG0000005233640
Ccr8 / P56484 / C-C chemokine receptor type 8 / P51685* / C-C motif chemokine receptor 8*ENSMUSG0000004226238
Ccr6 / O54689 / Mus musculus chemokine (C-C motif) receptor 6 (Ccr6), transcript variant 7, mRNA. / P51684* / C-C motif chemokine receptor 6*ENSMUSG0000004089932
Ccr7 / P47774 / C-C chemokine receptor type 7 / P32248* / C-C motif chemokine receptor 7*ENSMUSG0000003794432
Ccr9 / Q9WUT7 / C-C chemokine receptor type 9 / P51686* / C-C motif chemokine receptor 9*ENSMUSG0000002953031
Ackr2 / O08707 / atypical chemokine receptor 2 / O00590*ENSMUSG0000004453431
Cxcr3 / O88410 / C-X-C chemokine receptor type 3 / P49682* / C-X-C motif chemokine receptor 3*ENSMUSG0000005023230
Cxcr6 / Q9EQ16 / C-X-C chemokine receptor type 6 / O00574* / C-X-C motif chemokine receptor 6*ENSMUSG0000004852130
Xcr1 / chemokine (C motif) receptor 1 / P46094* / X-C motif chemokine receptor 1*ENSMUSG0000006050930
Ackr4 / Q924I3 / atypical chemokine receptor 4 / Q9NPB9*ENSMUSG0000007935529
Cxcr2 / P35343 / C-X-C chemokine receptor type 2 / P25025* / C-X-C motif chemokine receptor 2*ENSMUSG0000002618029
Cxcr1 / Q810W6 / C-X-C chemokine receptor type 1 / P25024* / C-X-C motif chemokine receptor 1*ENSMUSG0000004848029
Ccr10 / Q9JL21 / C-C chemokine receptor type 10 / P46092* / C-C motif chemokine receptor 10*ENSMUSG0000004405227
Cxcr5 / Q04683 / C-X-C chemokine receptor type 5 / P32302* / C-X-C motif chemokine receptor 5*ENSMUSG0000004788027
Cxcr4 / Mus musculus chemokine (C-X-C motif) receptor 4 (Cxcr4), transcript variant 2, mRNA. / P61073* / C-X-C motif chemokine receptor 4*ENSMUSG0000004538226


Protein motifs (from Interpro)
Interpro ID Name
 IPR000276  G protein-coupled receptor, rhodopsin-like
 IPR000355  Chemokine receptor family
 IPR002238  CC chemokine receptor 3
 IPR017452  GPCR, rhodopsin-like, 7TM


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0001938 positive regulation of endothelial cell proliferation IMP
 biological_processGO:0006935 chemotaxis IDA
 biological_processGO:0006954 inflammatory response IEA
 biological_processGO:0007165 signal transduction IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0045766 positive regulation of angiogenesis IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway IEA
 cellular_componentGO:0005886 plasma membrane IEA
 cellular_componentGO:0016020 membrane IEA
 cellular_componentGO:0016021 integral component of membrane IEA
 molecular_functionGO:0004871 obsolete signal transducer activity IEA
 molecular_functionGO:0004930 G-protein coupled receptor activity IEA
 molecular_functionGO:0004950 chemokine receptor activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0016493 C-C chemokine receptor activity IDA
 molecular_functionGO:0019957 C-C chemokine binding IEA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000223 decreased monocyte count "fewer than normal monocyte numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0001952 increased airway responsiveness "more easily provoked into bronchoconstriction in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002133 abnormal respiratory system physiology "anomalous function of the pulmonary system; inability or reduced ability to intake and exchange oxygen and carbon dioxide with the environment" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002334 abnormal airway responsiveness "anomalous response in bronchial provocation tests" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002423 abnormal mast cell physiology "anomalous response of the granulated cells found in most tissues and which contain large amounts of histamine and heparin in granules" [MeSH:National Library of Medicine - Medical Subject Headings , 2003]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002465 abnormal eosinophil physiology "abnormal function of the leukocyte that stains with eosin and is involved in clearance of parasitic infections and in allergic reactions " [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002602 abnormal eosinophil count "deviation from the normal numbers of eosinophils" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005011 increased eosinophil count "greater than normal eosinophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005012 decreased eosinophil count "fewer than normal eosinophil numbers " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008603 decreased circulating interleukin-4 level "reduction in the amount in the blood of a soluble factor produced by activated T-cells that induces the expression of MHC class II genes and FC receptors on B-cells and causes their proliferation and differentiation; it also acts on T-cells, mast cells and several other hematopoietic lineage cells" [MESH:D12.644.276.374.465.504]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008723 impaired eosinophil recruitment "reduced diffusion or accumulation of eosinophils in tissues or cells in response to a wide variety of substances released at the sites of inflammatory reactions" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008724 impaired eosinophil migration "defect in the ability of eosinophils to move along a chemotactic gradient" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008764 increased mast cell degranulation "increase in the exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell" [GO:0043303, MGI:tmeehan "Terry Meehan, Mouse Genome Informatics Curator"]
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Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0009676 abnormal hemostasis "any anomaly in the spontaneous arrest of bleeding from vessels carrying blood under pressure or the arrest of circulation to an organ or part" [MESH:G09.188.124.560, MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035042 Ccl5 / P30882 / C-C motif chemokine 5 / P13501* / C-C motif chemokine ligand 5*  / reaction / complex






 

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