ENSMUSG00000035042


Mus musculus

Features
Gene ID: ENSMUSG00000035042
  
Biological name :Ccl5
  
Synonyms : Ccl5 / C-C motif chemokine 5 / P30882
  
Possible biological names infered from orthology : C-C motif chemokine ligand 5 / P13501
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: C
Gene start: 83525778
Gene end: 83530518
  
Corresponding Affymetrix probe sets: 10389207 (MoGene1.0st)   1418126_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000039600
NCBI entrez gene - 20304     See in Manteia.
MGI - MGI:98262
RefSeq - NM_013653
RefSeq Peptide - NP_038681
swissprot - P30882
swissprot - Q5XZF2
Ensembl - ENSMUSG00000035042
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccl35.1ENSDARG00000103466Danio rerio
 ccl35.2ENSDARG00000070378Danio rerio
 CCL5ENSGALG00000043603Gallus gallus
 CCL5ENSG00000271503Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccl4 / P14097 / C-C motif chemokine 4 / Q8NHW4* / CCL4L2* / P13236* / C-C motif chemokine ligand 4* / C-C motif chemokine ligand 4 like 2*ENSMUSG0000001893051
Ccl3 / P10855 / C-C motif chemokine 3 / CCL18* / P55774* / CCL3L1* / CCL3L3* / P10147* / P16619* / C-C motif chemokine ligand 3* / C-C motif chemokine ligand 18* / C-C motif chemokine liga...ENSMUSG0000000098249
Ccl26 / chemokine (C-C motif) ligand 26 / Q9Y258* / C-C motif chemokine ligand 26*ENSMUSG0000007046427


Protein motifs (from Interpro)
Interpro ID Name
 IPR000827  CC chemokine, conserved site
 IPR001811  Chemokine interleukin-8-like domain
 IPR030595  C-C motif chemokine 5
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade IEA
 biological_processGO:0002230 positive regulation of defense response to virus by host IC
 biological_processGO:0006816 calcium ion transport IEA
 biological_processGO:0006874 cellular calcium ion homeostasis IEA
 biological_processGO:0006887 exocytosis IEA
 biological_processGO:0006935 chemotaxis IEA
 biological_processGO:0006954 inflammatory response ISO
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007159 leukocyte cell-cell adhesion IEA
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IEA
 biological_processGO:0007267 cell-cell signaling IEA
 biological_processGO:0009615 response to virus IEA
 biological_processGO:0009636 response to toxic substance IEA
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010759 positive regulation of macrophage chemotaxis IEA
 biological_processGO:0010820 positive regulation of T cell chemotaxis IEA
 biological_processGO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling IEA
 biological_processGO:0014911 positive regulation of smooth muscle cell migration IEA
 biological_processGO:0030335 positive regulation of cell migration IEA
 biological_processGO:0030593 neutrophil chemotaxis IBA
 biological_processGO:0031328 positive regulation of cellular biosynthetic process IEA
 biological_processGO:0031584 activation of phospholipase D activity IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway IEA
 biological_processGO:0033634 positive regulation of cell-cell adhesion mediated by integrin IEA
 biological_processGO:0034097 response to cytokine IDA
 biological_processGO:0034112 positive regulation of homotypic cell-cell adhesion IEA
 biological_processGO:0034612 response to tumor necrosis factor IDA
 biological_processGO:0042102 positive regulation of T cell proliferation IEA
 biological_processGO:0042119 neutrophil activation IEA
 biological_processGO:0042327 positive regulation of phosphorylation IEA
 biological_processGO:0042531 positive regulation of tyrosine phosphorylation of STAT protein IEA
 biological_processGO:0043491 protein kinase B signaling IEA
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0043922 negative regulation by host of viral transcription IEA
 biological_processGO:0044344 cellular response to fibroblast growth factor stimulus IEA
 biological_processGO:0045071 negative regulation of viral genome replication IEA
 biological_processGO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway IEA
 biological_processGO:0045785 positive regulation of cell adhesion IEA
 biological_processGO:0048245 eosinophil chemotaxis IEA
 biological_processGO:0048247 lymphocyte chemotaxis IBA
 biological_processGO:0048661 positive regulation of smooth muscle cell proliferation IEA
 biological_processGO:0050679 positive regulation of epithelial cell proliferation IMP
 biological_processGO:0050796 regulation of insulin secretion IEA
 biological_processGO:0050863 regulation of T cell activation IEA
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0051262 protein tetramerization IEA
 biological_processGO:0051928 positive regulation of calcium ion transport IEA
 biological_processGO:0061098 positive regulation of protein tyrosine kinase activity IEA
 biological_processGO:0070098 chemokine-mediated signaling pathway ISS
 biological_processGO:0070100 negative regulation of chemokine-mediated signaling pathway IEA
 biological_processGO:0070233 negative regulation of T cell apoptotic process IEA
 biological_processGO:0070234 positive regulation of T cell apoptotic process IEA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade IBA
 biological_processGO:0071346 cellular response to interferon-gamma IEA
 biological_processGO:0071347 cellular response to interleukin-1 IEA
 biological_processGO:0071356 cellular response to tumor necrosis factor IEA
 biological_processGO:0071407 cellular response to organic cyclic compound IEA
 biological_processGO:0090026 positive regulation of monocyte chemotaxis IDA
 biological_processGO:1901214 regulation of neuron death IEA
 biological_processGO:2000110 negative regulation of macrophage apoptotic process IMP
 biological_processGO:2000343 positive regulation of chemokine (C-X-C motif) ligand 2 production NAS
 biological_processGO:2000406 positive regulation of T cell migration IEA
 biological_processGO:2000503 positive regulation of natural killer cell chemotaxis IEA
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IDA
 cellular_componentGO:0005737 cytoplasm IDA
 molecular_functionGO:0004435 phosphatidylinositol phospholipase C activity IEA
 molecular_functionGO:0004672 protein kinase activity IEA
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0008009 chemokine activity ISS
 molecular_functionGO:0016004 phospholipase activator activity IEA
 molecular_functionGO:0030298 receptor signaling protein tyrosine kinase activator activity IEA
 molecular_functionGO:0031726 CCR1 chemokine receptor binding IDA
 molecular_functionGO:0031729 CCR4 chemokine receptor binding IEA
 molecular_functionGO:0031730 CCR5 chemokine receptor binding ISS
 molecular_functionGO:0042056 chemoattractant activity IEA
 molecular_functionGO:0042379 chemokine receptor binding IEA
 molecular_functionGO:0042802 identical protein binding IEA
 molecular_functionGO:0042803 protein homodimerization activity IEA
 molecular_functionGO:0043621 protein self-association IEA
 molecular_functionGO:0046817 chemokine receptor antagonist activity IEA


Pathways (from Reactome)
Pathway description
Chemokine receptors bind chemokines
G alpha (i) signalling events


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0005095 decreased T cell proliferation "reduced clonal expansion of naive T cells in response to stimuli" [Immunobiology , The Immune System in Health and Disease:ISBN 0-8153-1691-7]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0005616 decreased susceptibility to type IV hypersensitivity reaction "less likelihood of or resistance to developing an antigen-elicited cellular immune reaction that results in tissue damage, but does not require Ab participation; the response is seen at the area of contact" [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008075 decreased CD4-positive T cell number "reduced number of the subset of T lymphocytes that carry the CD4 marker, recognize intravesicular peptides bound to MHC class-II molecules, and turn on antibody production" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008567 decreased interferon-gamma secretion "reduction in the production or release of the major interferon produced by mitogenically or antigenically stimulated lymphocytes that is involved in immunoregulation" [MESH:D12.644.276.374.440.893]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0008688 decreased interleukin-2 secretion "reduction in the production or release of a soluble substance elaborated by antigen- or mitogen-stimulated T-cells which induces DNA synthesis in naive lymphocytes" [MESH:D12.644.276.374.465.502]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
 ENSMUSG00000035448 Ccr3 / P51678 / Probable C-C chemokine receptor type 3 / P51677* / C-C motif chemokine receptor 3*  / complex / reaction
 ENSMUSG00000047898 Ccr4 / P51680 / C-C chemokine receptor type 4 / P51679* / C-C motif chemokine receptor 4*  / reaction / complex
 ENSMUSG00000079227 Ccr5 / P51682 / C-C chemokine receptor type 5 / P51681* / C-C motif chemokine receptor 5 (gene/pseudogene)*  / reaction / complex






 

0 s.

 
External programs and data are copyrighted by and are the property of their respective authors.
The Manteia system, data and analyses are provided "as is" with no warranties, expressed or implied as to capabilities or accuracy. User assumes the entire risk as to the results and performance of the software, data and documentation


                   

© Olivier Tassy / Olivier Pourquie 2007-2024
contact: otassy@igbmc.fr