ENSMUSG00000000982


Mus musculus

Features
Gene ID: ENSMUSG00000000982
  
Biological name :Ccl3
  
Synonyms : Ccl3 / C-C motif chemokine 3 / P10855
  
Possible biological names infered from orthology : CCL18 / CCL3L1 / CCL3L3 / C-C motif chemokine ligand 18 / C-C motif chemokine ligand 3 / C-C motif chemokine ligand 3 like 1 / P10147 / P16619 / P55774
  
Species: Mus musculus
  
Chr. number: 11
Strand: -1
Band: C
Gene start: 83647844
Gene end: 83649355
  
Corresponding Affymetrix probe sets: 10389231 (MoGene1.0st)   1419561_at (Mouse Genome 430 2.0 Array)   
  
Cross references: Ensembl peptide - ENSMUSP00000001008
NCBI entrez gene - 20302     See in Manteia.
MGI - MGI:98260
RefSeq - NM_011337
RefSeq Peptide - NP_035467
swissprot - P10855
swissprot - Q5QNW0
Ensembl - ENSMUSG00000000982
  
See expression report in BioGPS
See gene description in Wikigenes
See co-cited genes in PubMed


Ortholog prediction (from Ensembl)
Ortholog nameID Species
 ccl35.1ENSDARG00000103466Danio rerio
 ccl35.2ENSDARG00000070378Danio rerio
 ENSGALG00000041079Gallus gallus
 ENSGALG00000043065Gallus gallus
 ENSGALG00000014585Gallus gallus
 CCAH221ENSGALG00000027051Gallus gallus
 CCL4ENSGALG00000034478Gallus gallus
 CCL4ENSGALG00000032717Gallus gallus
 CCL18ENSG00000275385Homo sapiens
 CCL3ENSG00000277632Homo sapiens
 CCL3L1ENSG00000276085Homo sapiens


Paralog prediction (from Ensembl)
Paralog nameIDSimilarity(%)
Ccl4 / P14097 / C-C motif chemokine 4 / Q8NHW4* / CCL4L2* / P13236* / C-C motif chemokine ligand 4* / C-C motif chemokine ligand 4 like 2*ENSMUSG0000001893060
Ccl5 / P30882 / C-C motif chemokine 5 / P13501* / C-C motif chemokine ligand 5*ENSMUSG0000003504249
Ccl26 / chemokine (C-C motif) ligand 26 / Q9Y258* / C-C motif chemokine ligand 26*ENSMUSG0000007046428


Protein motifs (from Interpro)
Interpro ID Name
 IPR000827  CC chemokine, conserved site
 IPR001811  Chemokine interleukin-8-like domain
 IPR036048  Chemokine interleukin-8-like superfamily


Gene Ontology (GO)
TypeGO IDTermEv.Code
 biological_processGO:0000165 MAPK cascade ISS
 biological_processGO:0001649 osteoblast differentiation ISS
 biological_processGO:0001775 cell activation ISS
 biological_processGO:0002548 monocyte chemotaxis IBA
 biological_processGO:0006468 protein phosphorylation ISS
 biological_processGO:0006816 calcium ion transport ISS
 biological_processGO:0006874 cellular calcium ion homeostasis ISS
 biological_processGO:0006887 exocytosis ISS
 biological_processGO:0006935 chemotaxis ISS
 biological_processGO:0006954 inflammatory response ISS
 biological_processGO:0006955 immune response IEA
 biological_processGO:0007010 cytoskeleton organization ISS
 biological_processGO:0007186 G-protein coupled receptor signaling pathway IBA
 biological_processGO:0007204 positive regulation of cytosolic calcium ion concentration IEA
 biological_processGO:0007267 cell-cell signaling ISS
 biological_processGO:0008360 regulation of cell shape IDA
 biological_processGO:0009636 response to toxic substance ISS
 biological_processGO:0010469 regulation of signaling receptor activity IEA
 biological_processGO:0010628 positive regulation of gene expression ISS
 biological_processGO:0010629 negative regulation of gene expression ISS
 biological_processGO:0010818 T cell chemotaxis ISS
 biological_processGO:0014808 release of sequestered calcium ion into cytosol by sarcoplasmic reticulum ISS
 biological_processGO:0019722 calcium-mediated signaling ISS
 biological_processGO:0023052 signaling ISS
 biological_processGO:0030335 positive regulation of cell migration ISS
 biological_processGO:0030593 neutrophil chemotaxis IEA
 biological_processGO:0030595 leukocyte chemotaxis IEA
 biological_processGO:0031663 lipopolysaccharide-mediated signaling pathway ISS
 biological_processGO:0032760 positive regulation of tumor necrosis factor production IGI
 biological_processGO:0042493 response to drug IEA
 biological_processGO:0043308 eosinophil degranulation ISS
 biological_processGO:0043491 protein kinase B signaling ISS
 biological_processGO:0043525 positive regulation of neuron apoptotic process IGI
 biological_processGO:0043547 positive regulation of GTPase activity IBA
 biological_processGO:0043615 astrocyte cell migration IDA
 biological_processGO:0043922 negative regulation by host of viral transcription ISS
 biological_processGO:0045671 negative regulation of osteoclast differentiation ISS
 biological_processGO:0045672 positive regulation of osteoclast differentiation IEA
 biological_processGO:0045944 positive regulation of transcription by RNA polymerase II IMP
 biological_processGO:0048245 eosinophil chemotaxis ISS
 biological_processGO:0048246 macrophage chemotaxis IGI
 biological_processGO:0048247 lymphocyte chemotaxis IBA
 biological_processGO:0050718 positive regulation of interleukin-1 beta secretion IGI
 biological_processGO:0050729 positive regulation of inflammatory response IGI
 biological_processGO:0050850 positive regulation of calcium-mediated signaling ISS
 biological_processGO:0050918 positive chemotaxis IEA
 biological_processGO:0051928 positive regulation of calcium ion transport ISS
 biological_processGO:0051930 regulation of sensory perception of pain ISS
 biological_processGO:0070098 chemokine-mediated signaling pathway IBA
 biological_processGO:0070374 positive regulation of ERK1 and ERK2 cascade ISS
 biological_processGO:0070723 response to cholesterol ISS
 biological_processGO:0071346 cellular response to interferon-gamma IBA
 biological_processGO:0071347 cellular response to interleukin-1 IBA
 biological_processGO:0071356 cellular response to tumor necrosis factor IBA
 biological_processGO:0071407 cellular response to organic cyclic compound ISS
 biological_processGO:0071621 granulocyte chemotaxis ISS
 biological_processGO:2000503 positive regulation of natural killer cell chemotaxis ISS
 cellular_componentGO:0005576 extracellular region IEA
 cellular_componentGO:0005615 extracellular space IEA
 cellular_componentGO:0005622 intracellular ISS
 cellular_componentGO:0005623 cell IEA
 cellular_componentGO:0005737 cytoplasm ISS
 cellular_componentGO:0005829 cytosol ISS
 molecular_functionGO:0004672 protein kinase activity ISS
 molecular_functionGO:0004698 calcium-dependent protein kinase C activity ISS
 molecular_functionGO:0005125 cytokine activity IEA
 molecular_functionGO:0005515 protein binding IPI
 molecular_functionGO:0008009 chemokine activity IDA
 molecular_functionGO:0016004 phospholipase activator activity ISS
 molecular_functionGO:0016301 kinase activity ISS
 molecular_functionGO:0042056 chemoattractant activity ISS
 molecular_functionGO:0048020 CCR chemokine receptor binding IBA


Pathways (from Reactome)
Pathway description
No match


Phenotype (from MGI, Zfin or HPO)
IDPhenotypeDefinition Genetic BG
 MP:0000222 decreased neutrophil count "fewer than normal neutrophil numbers" [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0001463 abnormal spatial learning "defects in the abilibity to navigate using behavioraly meaningful locations" [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Ehmt1tm1.2Tara/Ehmt1+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0001516 abnormal motor coordination/ balance "altered ability of an animal to maintain skillful and effective interaction of movements or maintenance of equilibrium" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl3tm1Unc/Ccl3tm1Unc,Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Ccl3tm1Unc/Ccl3+,Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0001523 impaired righting response "reduced ability or greater amount of time needed to recover from supine position" [J:25565]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0002083 premature death "death after 3 weeks of age, but before normal life span" [csmith:Cynthia L. Smith , Mouse Genome Informatics Curator]
Show

Allelic Composition: Pcp2tm1Jim/Pcp2tm1Jim
Genetic Background: involves: 129S1/Sv * C57BL/6J

Allelic Composition: Ccl3tm1Unc/Ccl3+,Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0002410 decreased susceptibility to viral infection "reduced likelihood that an organism will develop ill effects from a viral infection or from components of or toxins produced by a virus " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002411 decreased susceptibility to bacterial infection "reduced likelihood that an organism will develop ill effects from a bacterial infection or from components of or toxins produced by bacteria " [cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0002570 alcohol aversion 
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0002805 abnormal conditioned taste aversion behavior "a defect in the ability of an animal to learn to avoid food sources that were previously associated with aversive internal stimuli or sickness such as a drug that induces sickness " [CFG:Center for Functional Genomics , Northwestern University]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0002862 altered righting response "altered ability or changed amount of time needed to recover from supine position" [hdene:Howard Dene , Mouse Genome Informatics Curator]
Show

Allelic Composition: Ccl3tm1Unc/Ccl3tm1Unc,Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Allelic Composition: Ccl3tm1Unc/Ccl3+,Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0003546 decreased alcohol consumption "less than normal consumption of alcohol" [RGD:Rat Genome Database submission]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0005614 decreased susceptibility to type III hypersensitivity reaction "less likelihood of or resistance to developing tissue injury mediated by immune complexes; generally involves immune complexes formed in the blood via Abs encountering circulating Ag; Ag-Ab complexes then deposit in tissues (especially blood vessels and glomeruli), induce complement activation, and result in tissue injury " [Pathology:ISBN 0-397-51047-0, cwg:Carroll-Ann W. Goldsmith , Mouse Genome Informatics curator]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0006082 CNS inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the brain and/or spinal cord" [smb:Susan M Bello, Mouse Genome Informatics Curator, ncbi:NCBI request]
Show

Allelic Composition: Ccl3tm1Unc/Ccl3tm1Unc,Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008432 abnormal long-term spatial reference memory "anomaly in long-term memory for spatial location information that is consolidated over hours and days after training or an encounter at that location" [MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ehmt1tm1.2Tara/Ehmt1+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0008752 abnormal tumor necrosis factor level "deviation from the normal levels of a serum glycoprotein produced by activated macrophages and NK cells and involved in initiating local inflammatory responses, particularly by its action on the endothelium of local blood vessels; its actions result in increased vascular permeability and induction of expression of adhesion molecules on the endothelium" [MESH:D12.644.276.374.500.800]
Show

Allelic Composition: Ccl3tm1Unc/Ccl3tm1Unc,Hexbtm1Rlp/Hexbtm1Rlp
Genetic Background: involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

 MP:0008916 abnormal astrocyte physiology "any functional anomaly of one of the large neuroglia cells of nervous tissue" [ISBN:0-683-40008-8 "Stedman s Medical Dictionary, 27th edition", MGI:csmith "Cynthia L. Smith, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Ehmt1tm1.2Tara/Ehmt1+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

 MP:0009481 cecum inflammation "local accumulation of fluid, plasma proteins, and leukocytes in the cecum" [MGI:anna "Anna V. Anagnostopoulos, Mouse Genome Informatics Curator"]
Show

Allelic Composition: Zp3tm1Pmw/Zp3tm1Pmw
Genetic Background: involves: 129S1/Sv * C57BL/6J

 MP:0011941 increased fluid intake "increase in the total amount of fluid taken in over time when compared to the normal state" [MGI:csmith]
Show

Allelic Composition: Sema3cL605P/Sema3c+
Genetic Background: C57BL/6J-Sema3cL605P

 MP:0020449 decreased microglial cell activation "decrease in the change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, during the maturation to the fully active phagocytic form" [GO:0001774]
Show

Allelic Composition: Ehmt1tm1.2Tara/Ehmt1+,Tg(CMV-cre)1Cgn/0
Genetic Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6

  


Interacting proteins (from Reactome)
Interactor ID Name Interaction type
No match






 

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